Skip to main content
Fig. 3 | Lipids in Health and Disease

Fig. 3

From: CircLDLR acts as a sponge for miR-667-5p to regulate SIRT1 expression in non-alcoholic fatty liver disease

Fig. 3

In vivo overexpression of circLDLR alleviates the NAFLD development through the autophagy signaling pathway activation. HFD-induced mice were treated with circLDLR overexpression plasmid and then injected with or without 3-MA, A the circLDLR expression in liver tissues of NAFLD mice was quantified via qRT-PCR. *P < 0.05 vs. Vector group; #P < 0.05 vs. circLDLR OE group. B and C An enzymatic method was performed to measure the contents of TG and TC from liver tissues. *P < 0.05 vs. Vector group, #P < 0.05 vs. circLDLR OE group. D The effects of in vivo overexpression of circLDLR were investigated through ORO staining and TEM analysis on the liver histology of NAFLD mice. *P < 0.05, **P < 0.01 vs. Vector group. E LC3 and p62 expressions in the livers of NAFLD mice were examined using western blot and relative quantification. ***P < 0.001 vs. Vector group; ##P < 0.01, ###P < 0.001 vs. circLDLR OE group

Back to article page