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Fig. 6 | Lipids in Health and Disease

Fig. 6

From: CircLDLR acts as a sponge for miR-667-5p to regulate SIRT1 expression in non-alcoholic fatty liver disease

Fig. 6

circLDLR regulates the SIRT1-autophagy signaling pathway to alleviate cells’ lipid accumulation. A The SIRT1 mRNA expression in Hepa1-6 cells. ***P < 0.001 vs. NC siRNA group. B The SIRT1 protein level in Hepa1-6 cells was determined using western blot. ***P < 0.001 vs. NC siRNA group. C ORO staining was determined to study the lipogenesis of si-SIRT1 in Hepa1-6 cells. **P < 0.01 vs. NC group. D and E The TG and TC contents in Hepa1-6 cells were detected via an enzymatic method. *P < 0.05 vs. NC group; #P < 0.05 vs. vector group. F LC3 and p62 expressions in Hepa1-6 cells were determined through western blot and relative quantification. *P < 0.05, ***P < 0.001 vs. vector group; ##P < 0.01, ###P < 0.001 vs. circLDLR OE group; &&P < 0.01, &&&P < 0.001 vs. vector + si-SIRT1 group

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