Table 4 Result of subgroup analysis of included studies in meta-analysis
Sub-grouped by | No. of trials | Effect sizea | 95% Confidence interval, P value | I2 (%) | P for heterogeneity | P for between subgroup heterogeneity |
|---|---|---|---|---|---|---|
Low density lipoprotein cholesterol | ||||||
Duration | 0.237 | |||||
≤ 8 weeks | 3 | −1.79 | (−6.60, 3.03), 0.467 | 0.0 | 0.974 | |
> 8 weeks | 3 | −8.43 | (−18.77, 1.92), 0.110 | 13.9 | 0.313 | |
Dose | 0.237 | |||||
< 30 g/day | 3 | −1.79 | (−6.60, 3.03), 0.467 | 0.0 | 0.974 | |
≥ 30 g/day | 3 | −8.43 | (−18.77, 1.92), 0.110 | 13.9 | 0.313 | |
Sex | 0.937 | |||||
Female | 1 | −4.00 | (−25.40, 17.40), 0.714 | – | – | |
Both | 5 | −3.12 | (−7.46, 1.21), 0.439 | 0.0 | 0.437 | |
Baseline BMI | 0.362 | |||||
≤ 25 | 2 | −1.67 | (−6.61, 3.27), | 0.0 | 0.923 | |
> 25 | 2 | −5.22 | (−14.89, 4.45), | 0.0 | 0.833 | |
Age | 0.638 | |||||
≤ 55 y | 3 | −3.65 | (−11.05, 3.76), 0.335 | 42.8 | 0.174 | |
> 55 y | 3 | −5.01 | (−13.83, 3.80), 0.265 | 0.0 | 0.973 | |
Total cholesterol | ||||||
Duration | 0.163 | |||||
≤ 8 weeks | 3 | −1.57 | (−7.82, 4.68), 0.622 | 0.0 | 0.949 | |
> 8 weeks | 3 | −11.64 | (−25.49, −2.21), 0.009 | 35.8 | 0.211 | |
Dose | 0.163 | |||||
< 30 g/day | 3 | −11.64 | (− 25.49, − 2.21), 0.009 | 35.8 | 0.211 | |
≥ 30 g/day | 3 | −1.57 | (−7.82, 4.68), 0.622 | 0.0 | 0.949 | |
Sex | 0.925 | |||||
Female | 1 | −5.00 | (−27.04, 17.04), 0.657 | – | – | |
Both | 5 | −4.54 | (−11.06, 1.97), 0.172 | 22.3 | 0.272 | |
Baseline BMI | 0.230 | |||||
≤ 25 | 2 | −1.27 | (−7.79, 5.25), 0.702 | 0.0 | 0.958 | |
> 25 | 2 | −6.00 | (−16.61, 4.62), 0.268 | 0.0 | 0.986 | |
Age | 0.652 | |||||
≤ 55 y | 3 | −5.69 | (−16.85, 5.46), 0.317 | 59.6 | 0.084 | |
> 55 y | 3 | −5.81 | (−15.37, 3.76), 0.234 | 0.0 | 0.997 | |