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Fig. 6 | Lipids in Health and Disease

Fig. 6

From: Exosomal IL-8 derived from Lung Cancer and Colon Cancer cells induced adipocyte atrophy via NF-κB signaling pathway

Fig. 6

NF-κB inhibitors partially mitigated lipolysis induced by exosomal IL-8. A The viability of 3 T3-L1 adipocytes treated with different doses of NF-κB inhibitor BAY11-7082 as assessed by CCK8. B-D Western blot and the densitometric analysis of phosphorylated-p65, total p65, UCP1, and PGC1α in adipocytes co-cultured with IL-8 (with and without BAY11-7082), LLC-EVs and/or C26-EVs (with and without BAY11-7082). The blot shown were representatives of three independent experiments. 10 μg EVs were used in this experiment. E Oil red O staining was assessed in the above groups. Bar = 100 μm. F Relative levels of glycerol release in cell supernatants with the above treatments. *P < 0.05, **P < 0.01, ***P < 0.001

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Lipids in Health and Disease

ISSN: 1476-511X