Table 4 Associations between changes in plasma levels of fatty acids and changes in plasma levels of Lp(a)
Trial 1 | Trial 2 | |||||||
|---|---|---|---|---|---|---|---|---|
Surgery-group | Lifestyle-group | Lifestyle-cohort | ||||||
Baseline—7 weeks (pre-surgery LED phase) | 7 weeks—59 weeks (post-surgery phase) | Baseline—59 weeks | Baseline—20 weeks | |||||
Betaa | P | Betaa | P | Betaa | P | Betaa | P | |
SFAs, % of total FA | ||||||||
Total SFA | -0.84 (-1.95, 0.27) | 0.14 | -3.61 (-5.75, -1.47) | 0.001 | -1.49 (-2.27, -0.72) | < 0.001 | -1.51 (-3.47, 0.45) | 0.13 |
Myristic acid, 14:0 | -4.41 (-9.95, 1.13) | 0.12 | -2.81 (-12.7, 7.05) | 0.57 | -3.94 (-8.36, 0.47) | 0.08 | -7.67 (-17.6, 2.29) | 0.13 |
Pentadecylic acid, 15:0 | 16.2 (-10.7, 43.0) | 0.24 | -4.88 (-52.9, 43.1) | 0.84 | 5.13 (-22.0, 32.2) | 0.71 | -41.0 (-96.9, 14.9) | 0.15 |
Palmitic acid, 16:0 | -0.50 (-1.72, 0.72) | 0.41 | -3.65 (-5.72, -1.58) | 0.001 | -1.55 (-2.60, -0.50) | 0.004 | -0.89 (-3.30, 1.52) | 0.47 |
Stearic acid, C18:0 | -1.63 (-4.42, 1.15) | 0.25 | 0.16 (-3.55, 3.87) | 0.93 | -2.13 (-4.22, -0.05) | 0.045 | -5.17 (-11.2, 0.83) | 0.09 |
MUFAs, % of total FA | ||||||||
Total MUFA | -0.81 (-1.38, -0.22) | 0.007 | -0.96 (-2.15, 0.22) | 0.11 | -0.44 (-0.98, 0.11) | 0.12 | 1.25 (-0.00, 2.50) | 0.05 |
Palmitoleic acid, 16:1 n-7 | -1.49 (-4.43, 1.45) | 0.32 | -2.72 (-8.02, 2.58) | 0.31 | -2.71 (-5.43, 0.01) | 0.05 | -3.05 (-10.3, 4.23) | 0.41 |
Oleic acid, 18:1 n-9 | -0.90 (-1.59, -0.20) | 0.012 | -1.25 (-2.70, 0.20) | 0.09 | -0.51 (-1.14, 0.12) | 0.11 | 1.67 (0.28, 3.06) | 0.019 |
Vaccenic acid, 18:1 n-7 cis | 4.79 (-2.62, 12.2) | 0.20 | -4.11 (-16.2, 7.93) | 0.50 | 7.22 (-0.14, 14.6) | 0.05 | 7.73 (-7.40, 22.9) | 0.31 |
Eicosenoic acid, 20:1 n-9 | 1.57 (-29.3, 32.4) | 0.92 | 6.63 (-37.2, 50.5) | 0.76 | 4.07 (-22.5, 30.7) | 0.76 | 35.0 (-40.6, 110.5) | 0.36 |
n-6 PUFAs, % of total FA | ||||||||
Total n-6 PUFAs | 0.41 (-0.05, 0.88) | 0.08 | 1.51 (0.66, 2.35) | 0.001 | 0.46 (0.08, 0.84) | 0.019 | 0.04 (-1.09, 1.16) | 0.95 |
LA, C18:2 n-6 | 0.21 (-0.32, 0.75) | 0.43 | 1.37 (0.42, 2.32) | 0.005 | 0.49 (0.12, 0.86) | 0.011 | -0.69 (-1.97, 0.60) | 0.29 |
GLA, C18:3 n-6 | -6.66 (-19.2, 5.84) | 0.10 | 1.23 (-18.6, 21.1) | 0.90 | -4.60 (-16.0, 6.79) | 0.42 | -11.9 (-35.4, 11.6) | 0.32 |
EDA, C20:2 n-6 | -3.68 (-48.7, 41.4) | 0.87 | 5.55 (-50.7, 61.8) | 0.85 | -30.4 (-65.1, 4.30) | 0.09 | 36.9 (-44.9, 118.6) | 0.37 |
DGLA, C20:3 n-6 | 0.98 (-4.27, 6.23) | 0.71 | -7.38 (-11.1, -3.70) | 0.71 | 0.63 (-3.98, 5.23) | 0.79 | 7.61 (-6.11, 21.3) | 0.28 |
AA, C20:4 n-6 | 0.92 (-0.21, 2.06) | 0.11 | 0.24 (-1.58, 2.05) | 0.80 | 1.70 (0.24, 3.16) | 0.023 | 1.91 (-1.06, 4.89) | 0.21 |
n-3 PUFAs, % of total FA | ||||||||
Total n-3 PUFAs | 2.43 (0.45, 4.42) | 0.017 | -0.27 (-2.14, 1.60) | 0.77 | 0.75 (-0.61, 2.11) | 0.28 | -0.92 (-3.84, 2.01) | 0.54 |
ALA, C18:3 n-3 | -10.9 (-23.7, 1.99) | 0.10 | 5.65 (-12.3, 23.6) | 0.53 | -1.68 (-11.4, 8.07) | 0.73 | 3.91 (-12.1, 19.9) | 0.63 |
EPA, C20:5 n-3 | 4.90 (0.83, 8.97) | 0.02 | -0.26 (-3.80, 3.27) | 0.88 | 0.67 (-1.48, 2.82) | 0.54 | -2.18 (-8.54, 4.17) | 0.50 |
DPA, C22:5 n-3 | 10.1 8–9.51, 29.8) | 0.31 | -0.68 (-24.1, 22.7) | 0.95 | 4.77 (-9.94, 19.5) | 0.52 | -10.5 (-53.6, 32.6) | 0.63 |
DHA, C22:6 n-3 | 3.85 (0.46, 7.24) | 0.026 | -1.16 (-5.15, 2.82) | 0.56 | 3.51 (0.01, 7.00) | 0.049 | -2.06 (-7.81, 3.69) | 0.48 |