Parameters | Group A (n = 21) | Group B (n = 20) | Group C (n = 20) | Group D (n = 20) | P |
---|---|---|---|---|---|
Sex (male/female, n) | 15/6 | 8/12 | 12/8 | 7/13 | 0.067 |
Age (year) | 52.0 ± 13.2 | 56.1 ± 6.7 | 56.0 ± 7.9 | 58.0 ± 10.9 | 0.259 |
Diabetes duration (year) (year) | 5.7 ± 4.6 | 6.6 ± 5.3 | 6.4 ± 4.5 | 5.6 ± 4.6 | 0.561 |
BMI (kg/m2) | 27.1 ± 4.2 | 25.1 ± 3.4a | 23.0 ± 4.22ab | 22.89 ± 3.49ab | ˂0.01 |
SBP (mmHg) | 146 ± 17.9 | 138 ± 16.1a | 128 ± 14.4ab 3a | 127 ± 13.3ab | ˂0.01 |
DBP (mmHg) | 89 ± 13.5 | 82 ± 10.72a | 76. ± 8.2a | 77 ± 10.14ab | 0.025 |
TC (mmol/L) | 6.5 ± 1.2 | 5.3 ± 1.53a | 5.5 ± 1.1ab | 5.0 ± 1.0ab | 0.049 |
TG (mmol/L) | 3.5 ± 2.2 | 2.5 ± 0.8 a | 1.7 ± 1.2ab | 1.5 ± 0.7ab | ˂0.01 |
LDL-C (mmol/L) | 3.3 ± 0.9 | 3.1 ± 1.0 | 3.4 ± 0.9 | 2.9 ± 0.9 | 0.359 |
HDL-C (mmol/L) | 1.1 ± 0.3 | 1.2 ± 0.3 | 1.3 ± 0.4 | 1.2 ± 0.3 | 0.227 |
ApoA (mmol/L) | 1.4 ± 0.25 | 1.49 ± 0.24 | 1.46 ± 0.28 | 0.34 ± 0.27 | 0.227 |
ApoB (mmol/L) | 1.3 ± 0.2 | 1.1 ± 0.3 | 1.2 ± 0.3 | 1.1 ± 0.3 | 0.066 |
Lipoprotein (a) (mg/dL) | 296.7 ± 166.1 | 282.5 ± 155.6 | 263.10 ± 195.1 | 300.40 ± 160.2 | 0.896 |
ALT (U/L) | 53.7 ± 59.4 | 40.0 ± 62.7a | 22.1 ± 10.0ab | 21.4 ± 18.3ab | ˂0.01 |
AST (U/L) | 35.1 ± 20.1 | 25.5 ± 32.3a | 18.2 ± 4.7ab | 20.4 ± 9.3ab | ˂0.01 |
GGT (U/L) | 43.9 ± 35.1 | 34.6 ± 24.1a | 28.0 ± 20.3ab | 27.4 ± 28.9ab | ˂0.01 |
ALP (U/L) | 88.0 ± 22.9 | 86.1 ± 36.8 | 87.0 ± 27.1 | 80.5 ± 24.0 | 0.444 |
UA (mol/L) | 359.8 ± 88.4 | 346.2 ± 99.9 | 315.8 ± 85.9 | 329.2 ± 99.8 | 0.465 |
SCr (umol/L) | 66.1 ± 21.2 | 62.7 ± 22.8 | 60.2 ± 17.1 | 67.8 ± 29.5 | 0.722 |
BUN (mmol/L) | 5.1 ± 1.6 | 4.8 ± 1.8 | 5.1 ± 1.3 | 5.1 ± 1.4 | 0.927 |
CYC (mg/L) | 1.1 ± 0.3 | 1.2 ± 0.4 | 1.0 ± 0.3 | 1.1 ± 0.4 | 0.453 |
FPG (mmol/L) | 9.4 ± 3.2 | 9.1 ± 1.8 | 9.5 ± 2.5 | 8.8 ± 2.1 | 0.183 |
2 h PG (mmol/L) | 19.0 ± 5.4 | 17.0 ± 3.6 | 17.9 ± 4.5 | 16.1 ± 3.8 | 0.183 |
HbA1c (%) | 9.7 ± 2.5 | 9.6 ± 1.9 | 9.8 ± 2.6 | 8.6 ± 2.2 | 0.749 |
FCP (mmol/L) | 1.9 ± 0.8 | 1.5 ± 0.9a | 1.1 ± 0.6ab | 1.1 ± 0.7ab | 0.022 |
2 h CP (mmol/L) | 5.5 ± 2.6 | 4.2 ± 2.2a | 2.9 ± 1.9ab | 3.2 ± 2.2ab | ˂0.01 |
HOMA-IR | 3.9 ± 2.1 | 3.0 ± 1.7a | 2.2 ± 0.9ab | 2.0 ± 1.2ab | ˂0.01 |
HOMA-IS | 35.9 ± 22.4 | 27.1 ± 17.8a | 21.1 ± 17.9ab | 20.3 ± 11.6ab | 0.030 |