Skip to main content

Table 1 Trajectory analysis and stabilizing residues of the deleterious SNPs. Destabilizing residues are shown in bold. (E- Extracellular, C-coil, S-strands)

From: In silico profiling of nonsynonymous SNPs of fat mass and obesity-associated gene: possible impacts on the treatment of non-alcoholic fatty liver disease

S.NO

Residual change

SRide(stabilizing residue)

PSIPRED

ConSurf

Missense3D (structural damage)

Native (N)

Mutant (M)

Native (N)

Mutant (M)

1

Native

ILE99, VAL116, TRP118,ASN205, ALA243, ALA311

     

2

R96P

ILE99, VAL116, TRP118, ASN205, ALA243, TRP270, ALA311

E

E

9

8

Damaged

3

G103D

ILE99, VAL116, TRP118, ASN205, ALA243, TRP270, ALA311

S

C

9

7

Damaged

4

Y295C

ILE99, VAL116, TRP118, ASN205, TRP270, ALA311

S

S

9

9

Damaged

5

R316Q

ILE99, VAL116, TRP118, ALA243, TRP270, ALA311

E

E

9

9

Damaged

6

R322Q

ILE99, VAL116, TRP118, ASN205, TRP270, ALA311

C

S

9

9

Damaged

Back to article page

Lipids in Health and Disease

ISSN: 1476-511X