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Table 4 Predicted binding affinity of drug molecules with FTO native and mutant forms obtained from AutoDock Vina

From: In silico profiling of nonsynonymous SNPs of fat mass and obesity-associated gene: possible impacts on the treatment of non-alcoholic fatty liver disease

S.No

Target Protein

Predicted Binding Affinity (kcal/mol)

Capsaicin

Resveratrol

Rosamarinic acid

1

FTO Native

-7.8

-7.8

-9.2

2

FTO R96P

-7.7

-7.6

-8.7

3

FTO G103D

-7.9

-7.8

-8.9

4

FTO Y295C

-8.3

-7.8

-9.3

5

FTO R316Q

-8.6

-8.4

-9.2

6

FTO R322Q

-7.8

-7.6

-9.7