Table 4 The studied markers of serum, blood, and body organs. The mice received nisin (25, 50, or 100 μg/kg, i.p.) or placebo daily for 8 weeks. Blood or serum biomarkers and the weights of body organs were measured at the end of the experiment
From: Anti-obesity effect of the bacterial product nisin in an NIH Swiss mouse model
Nisin (μg/kg) | FBS (mg/dL) | Cholesterol (mg/dL) | Triglyceride (mg/dL) | HDL (mg/dL) | LDL (mg/dL) | AST (U/L) | ALT (IU/L) | ALP (IU/L) | RBC (× 106) | WBC (× 103) | Hb (g/dL) | PCV (%) | MCV (fL) | MCH (pg) | MCHC (g/dL) | Small Int (cm) | Kidney Wt (g) | Spleen Wt (g) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0 | 93 ± 6.4 | 116 ± 11.5 | 84.7 ± 14.6 | 48.6 ± 5 | 53 ± 5.1 | 369 ± 48.2 | 99.9 ± 10.6 | 176 ± 24 | 8.09 ± 0.357 | 5.16 ± 0.78 | 12.2 ± 0.6 | 40.1 ± 1.8 | 49.5 ± 0.6 | 15.1 ± 0.2 | 30.5 ± 0.3 | 49.9 ± 1.9 | 0.61 ± 0.02 | 0.27 ± 0.03 |
25 | 90.1 ± 3.6 | 113 ± 10.3 | 75.6 ± 8.9 | 46.2 ± 4.2 | 51.7 ± 4 | 317 ± 59.6 | 118 ± 25.9 | 182 ± 13.8 | 7.74 ± 0.244 | 4.98 ± 0.76 | 11.6 ± 0.3 | 38.6 ± 0.9 | 50.1 ± 1.4 | 15.1 ± 0.2 | 30.2 ± 0.5 | 49.6 ± 1.5 | 0.6 ± 0.04 | 0.31 ± 0.05 |
50 | 77.7 ± 9.8 | 128 ± 8.6 | 90.4 ± 12.1 | 50.4 ± 3.9 | 57 ± 4 | 412 ± 67.6 | 112 ± 8.5 | 163 ± 16.8 | 8.49 ± 0.418 | 6.76 ± 1.2 | 12.8 ± 0.7 | 42.1 ± 2.3 | 49.6 ± 1 | 15.1 ± 0.5 | 30.4 ± 0.5 | 46.2 ± 1.6 | 0.61 ± 0.04 | 0.4 ± 0.04 |
100 | 92.3 ± 3.9 | 114 ± 12.7 | 87 ± 6.5 | 49.1 ± 2.6 | 56.2 ± 3 | 465 ± 55 | 140 ± 26.7 | 175 ± 18.8 | 8.21 ± 0.565 | 5.99 ± 0.48 | 12.3 ± 0.8 | 42.1 ± 2.4 | 52 ± 1.6 | 15.1 ± 0.3 | 29 ± 0.4 | 48.2 ± 1.3 | 0.64 ± 0.04 | 0.38 ± 0.06 |