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Table 3 Comparison of lipoproteins concentrations obtained under fasting and non-fasting conditionsa

From: NMR derived changes of lipoprotein particle concentrations related to impaired fasting glucose, impaired glucose tolerance, or manifest type 2 diabetes mellitus

  

Control

IFG

IGT

IFG + IGT

T2D

Nf

 

196

167

21

29

19

Nnf

 

251

193

26

68

57

Lipoprotein

Fasting state

c [nM]

c [nM]

c [nM]

c [nM]

c [nM]

HDL A

Fasting

16,628 ± 2839

16,885 ± 2939

16,725 ± 2658

17,107 ± 2445

17,408 ± 2776

(7 – 8.5 nm)

Non-fasting

16,963 ± 3320

17,362 ± 2777

16,799 ± 2420

17,285 ± 2251

18,014 ± 2454

Δcnf-f [%]

2

2.8

0.4

1

3.5

HDL B

Fasting

4688 ± 1451

4247 ± 1331

4586 ± 1692

4724 ± 1530

4218 ± 1123

(8.5 – 10 nm)

Non-fasting

4623 ± 1442

4501 ± 1267

4479 ± 1778

4779 ± 1493

4390 ± 1156

Δcnf-f [%]

-1.4

6

-2.3

1.2

4.1

HDL C

Fasting

2445 ± 903

2106 ± 695

2309 ± 1086

 2259 ± 612

2004 ± 593

(10 – 13 nm)

Non-fasting

2407 ± 827

2270 ± 749

2300 ± 1049

2263 ± 614

2085 ± 565

Δcnf-f [%]

-1.6

7.8

-0.4

0.2

4.1

HDL D

Fasting

1159 ± 206

1111 ± 170

1184 ± 228

1174 ± 183

1125 ± 147

(13 – 16 nm)

Non-fasting

1154 ± 193

1158 ± 176

1193 ± 235

1170 ± 155

1149 ± 162

Δcnf-f [%]

-0.5

4.2

0.7

-0.3

2.1

HDL total

Fasting

24,921 ± 3488

24,349 ± 3423

24,805 ± 3272

25,265 ± 2840

24,754 ± 3003

(7 – 16 nm)

Non-fasting

25,147 ± 3874

25,290 ± 3234

24,771 ± 3104

25,498 ± 2947

25,638 ± 3128

Δcnf-f [%]

0.9

3.9

-0.1

0.9

3.6

Apo-A1NMRb

Fasting

49,842 ± 6976

48,698 ± 6845

49,611 ± 6543

50,529 ± 5679

49,508 ± 6006

Non-fasting

50,294 ± 7749

50,581 ± 6468

49,543 ± 6207

50,996 ± 5893

51,276 ± 6255

Δcnf-f [%]

0.9

3.9

-0.1

0.9

3.6

LDL A

Fasting

469.2 ± 127.2

426.4 ± 97.6

469.6 ± 172.6

455.1 ± 81.2

395.1 ± 97.6

(16 – 19 nm)

Non-fasting

465.5 ± 118.5

449.9 ± 105.7

461.4 ± 174.8

452.0 ± 87.9

420.7 ± 86.3

Δcnf-f [%]

-0.8

5.5

-1.7

-0.7

6.5

LDL B

Fasting

370.0 ± 74.3

354.3 ± 61.0

375.2 ± 85.6

374.5 ± 59.8

339.1 ± 59.0

(19 – 21 nm)

Non-fasting

369.4 ± 72.2

367.3 ± 66.0

374.2 ± 89.8

371.1 ± 57.4

358.8 ± 59.1

Δcnf-f [%]

-0.2

3.7

-0.3

-0.9

5.8

LDL C

Fasting

328.5 ± 66.5

314.9 ± 56.4

331.2 ± 78.5

328.6 ± 54.5

296.2 ± 63.4

(21 – 22 nm)

Non-fasting

329.9 ± 70.1

323.0 ± 64.7

326.7 ± 82.9

324.6 ± 53.9

311.5 ± 55.9

Δcnf-f [%]

0.4

2.6

-1.4

-1.2

5.1

LDL D

Fasting

221.3 ± 48.7

216.9 ± 45.1

225.0 ± 54.2

229.0 ± 51.1

205.1 ± 53.7

(22 – 25 nm)

Non-fasting

223.6 ± 57.1

223.1 ± 47.1

227.5 ± 59.1

224.0 ± 47.1

219.2 ± 47.0

Δcnf-f [%]

1

2.8

1.1

-2.2

6.9

LDL E

Fasting

175.6 ± 41.9

180.3 ± 41.0

185.4 ± 35.7

196.6 ± 58.0

169.8 ± 44.1

(25 – 30 nm)

Non-fasting

177.6 ± 53.2

183.2 ± 46.1

187.6 ± 38.2

191.5 ± 45.3

188.8 ± 47.8

Δcnf-f [%]

1.1

1.6

1.2

-2.6

11.2

LDL total

Fasting

1564.7 ± 328.1

1492.9 ± 273.4

1586.4 ± 406.0

1583.7 ± 266.8

1405.2 ± 286.3

(16 – 30 nm)

Non-fasting

1566.0 ± 336.1

1546.5 ± 301.0

1577.2 ± 423.9

1563.1 ± 262.4

1498.8 ± 271.7

Δcnf-f [%]

0.1

3.6

-0.6

-1.3

6.7

IDL

Fasting

83.41 ± 20.95

84.43 ± 20.27

83.41 ± 19.31

91.8 ± 28.37

78.71 ± 23.38

(30 – 40 nm)

Non-fasting

84.87 ± 27.24

85.67 ± 21.48

86.58 ± 19.4

88.13 ± 21.97

86.57 ± 22.98

Δcnf-f [%]

1.8

1.5

3.8

-4

10

VLDL A

Fasting

42.93 ± 13.76

45.08 ± 13.79

45.22 ± 12.18

51.88 ± 23.09

43.17 ± 15.54

(40 – 60 nm)

Non-fasting

43.33 ± 17.74

45.98 ± 14.42

48.03 ± 11.93

49.4 ± 15.7

48.95 ± 16.87

Δcnf-f [%]

0.9

2

6.2

-4.8

13.4

VLDL B

Fasting

9.92 ± 3.22

10.32 ± 3.26

10.1 ± 3.03

12.28 ± 6.02

9.35 ± 3.23

(60 – 80 nm)

Non-fasting

10.06 ± 4.34

10.5 ± 3.42

10.74 ± 2.68

11.35 ± 3.61

11.19 ± 4.11

Δcnf-f [%]

1.4

1.7

6.3

-7.6

19.7

IDL and VLDL

Fasting

136.26 ± 37.08

139.83 ± 36.48

138.72 ± 33.32

155.95 ± 56.55

131.22 ± 40.77

(30 – 80 nm)

Non-fasting

138.27 ± 48.51

142.15 ± 38.65

145.35 ± 32.75

148.88 ± 40.54

146.71 ± 43.34

Δcnf-f [%]

1.5

1.7

4.8

-4.5

11.8

Apo-B100NMRb

Fasting

1700.9 ± 352.0

1632.7 ± 300.9

1725.1 ± 431.3

1739.6 ± 310.7

1536.4 ± 318.3

Non-fasting

1704.2 ± 372.0

1688.6 ± 329.4

1722.6 ± 449.1

1712.0 ± 294.3

1645.5 ± 306.3

Δcnf-f [%]

0.2

3.4

-0.1

-1.6

7.1

CM Re

Fasting

0.66 ± 0.28

0.7 ± 0.28

0.7 ± 0.25

0.86 ± 0.52

0.68 ± 0.33

(80 – 100 nm)

Non-fasting

0.66 ± 0.35

0.73 ± 0.28

0.77 ± 0.23

0.8 ± 0.33

0.78 ± 0.34

Δcnf-f [%]

0

4.3

10

-7

14.7

CM A

Fasting

0.42 ± 0.17

0.44 ± 0.18

0.43 ± 0.16

0.56 ± 0.35

0.4 ± 0.17

(100 – 150 nm)

Non-fasting

0.42 ± 0.23

0.45 ± 0.18

0.47 ± 0.14

0.51 ± 0.2

0.5 ± 0.23

Δcnf-f [%]

0

2.3

9.3

-8.9

25

CM B

Fasting

0.075 ± 0.039

0.079 ± 0.04

0.076 ± 0.041

0.109 ± 0.083

0.066 ± 0.041

(> 150 nm)

Non-fasting

0.073 ± 0.051

0.082 ± 0.038

0.0810 ± 0.030

0.095 ± 0.046

0.088 ± 0.048

Δcnf-f [%]

-2.7

3.8

6.6

-12.8

33.3

CM total

Fasting

1.15 ± 0.48

1.22 ± 0.49

1.21 ± 0.45

1.53 ± 0.94

1.14 ± 0.54

(80 – 430 nm)

Non-fasting

1.15 ± 0.62

1.26 ± 0.49

1.32 ± 0.38

1.41 ± 0.57

1.37 ± 0.61

Δcnf-f [%]

0

3.3

9.1

-7.8

20.2

Apo-B48NMRb

Fasting

1.15 ± 0.48

1.22 ± 0.49

1.21 ± 0.45

1.53 ± 0.94

1.14 ± 0.54

Non-fasting

1.15 ± 0.62

1.26 ± 0.49

1.32 ± 0.38

1.41 ± 0.57

1.37 ± 0.61

Δcnf-f [%]

0

3.3

9.1

-7.8

20.2

  1. aFor lipoprotein nomenclature see Methods. The values given are the mean ± the standard deviation. The fasting values are from the spectra taken before the oGTT, the non-fasting values were extrapolated to time t = 0 from the spectra of reserve samples of the blood donors. Δcnf-f [%], relative particle concentrations c under non-fasting conditions minus those under fasting conditions. Number of participants analysed under fasting conditions (Nf) and non-fasting conditions (Nnf) 432 and 595, respectively. First column, values in bracket represent the diameters assumed for different subclasses
  2. bThe NMR derived apolipoprotein concentrations were calculated as described in Table 2