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  1. Betaine is a methyl donor and has been considered as a lipotropic effect substance. But its mechanism remains unclear. Hepatic steatosis is associated with abnormal expression of genes involved in hepatic lipi...

    Authors: Lijun Wang, Li Chen, Yaozong Tan, Jun Wei, Ying Chang, Tianru Jin and Huilian Zhu
    Citation: Lipids in Health and Disease 2013 12:34
    Content type: Research Published on:

  2. MicroRNAs (miRNAs) emerge as new important regulators of lipid homeostasis by regulating corresponding genes. MiR-613 is a newly discovered microRNA, of which the biological function is unknown. A recent repor...

    Authors: Dan Zhong, Yan Zhang, Yi-jun Zeng, Min Gao, Geng-ze Wu, Chang-jiang Hu, Gang Huang and Feng-tian He
    Citation: Lipids in Health and Disease 2013 12:32
    Content type: Research Published on:

  3. The aim of the present prospective study was to examine whether lipoprotein (a) [Lp(a)] phenotypes and/or low relative lymphocyte concentration (LRLC) are independently associated with coronary heart disease (...

    Authors: Tatsuya Suzuki, Shoko Futami-Suda, Yoshimasa Igari, Kentaro Watanabe, Motoshi Ouchi, Kazunari Suzuki, Ken-ichi Sekimizu, Yoshiaki Kigawa, Hiroshi Nakano and Kenzo Oba
    Citation: Lipids in Health and Disease 2013 12:31
    Content type: Research Published on:

  4. Exposure to the pyrethroid pesticide deltamethrin has been demonstrated to exert a wide range of effects on non-targeted organisms. The beneficial effects of geranuim essential oil (EO) as an antioxidant has b...

    Authors: Ahlem Ben Slima, Manel Ben Ali, Mohamed Barkallah, Al Ibrahim Traore, Tahia Boudawara, Noureddine Allouche and Radhouane Gdoura
    Citation: Lipids in Health and Disease 2013 12:30
    Content type: Research Published on:

  5. Obesity, oxidative stress and inflammation, by triggering insulin resistance, may contribute to the accumulation of hepatic fat, and this accumulation by lipotoxicity can lead the organ to fail. Because obesit...

    Authors: Leandro Pereira de Moura, Amanda Christine da Silva Sponton, Michel Barbosa de Araújo, Rodrigo Augusto Dalia, José Rodrigo Pauli and Maria Alice Rostom de Mello
    Citation: Lipids in Health and Disease 2013 12:29
    Content type: Research Published on:

  6. Intake of high-fat diet is associated with increased fatty livers. Hepatic lipid accumulation and oxidative stress are key pathophysiological mechanisms in this disease. Micronutrients polyphenols, tocopherols...

    Authors: Jiqu Xu, Xiaoqi Zhou, Hui Gao, Chang Chen, Qianchun Deng, Qingde Huang, Jing Ma, Zhengyang Wan, Jin’e Yang and Fenghong Huang
    Citation: Lipids in Health and Disease 2013 12:28
    Content type: Research Published on:

  7. Docosahexaenoic acid (DHA) is a long-chain omega-3 polyunsaturated fatty acid (LCPUFA) that is critically important for the structure, development and function of the retina and central nervous system (CNS), u...

    Authors: Hsiao-Ling Huang, Lu-Te Chuang, Hsi-Hsin Li, Chiu-Ping Lin and Robert H Glew
    Citation: Lipids in Health and Disease 2013 12:27
    Content type: Research Published on:

  8. Our previous work showed that dietary oxidized linoleic acid given, as a single fatty acid, to LDL receptor knockout mice decreased weight gain as compared to control mice. Other studies have also reported tha...

    Authors: Meera Penumetcha, Mary K Schneider, Holly A Cheek and Sonia Karabina
    Citation: Lipids in Health and Disease 2013 12:26
    Content type: Short report Published on:

  9. Lipid desaturase enzymes mediate the metabolism of fatty acids to long chain polyunsaturated fatty acids and their activities are related to metabolic risk factors for Type 2 diabetes (T2DM) and coronary heart...

    Authors: Robert G Gray, Eleni Kousta, Mark I McCarthy, Ian F Godsland, Soundarajan Venkatesan, Victor Anyaoku and Desmond G Johnston
    Citation: Lipids in Health and Disease 2013 12:25
    Content type: Research Published on:

  10. Mutation in SCARB1 gene, exon 8 rs5888, has been associated with altered lipid levels and cardiovascular risk in humans though the results have been inconsistent. We analysed the impact of SCARB1 single nucleo...

    Authors: Daiva Stanislovaitiene, Vaiva Lesauskaite, Dalia Zaliuniene, Alina Smalinskiene, Olivija Gustiene, Diana Zaliaduonyte-Peksiene, Abdonas Tamosiunas, Dalia Luksiene, Janina Petkeviciene and Remigijus Zaliunas
    Citation: Lipids in Health and Disease 2013 12:24
    Content type: Research Published on:

  11. HDL function rather than absolute level may be a more accurate indicator for risk of developing atherosclerosis. Dysfunctional HDL has increased redox activity and reduced antioxidant properties, but it is unk...

    Authors: Theodoros Kelesidis, Otto O Yang, Michelle A Kendall, Howard N Hodis and Judith S Currier
    Citation: Lipids in Health and Disease 2013 12:23
    Content type: Short report Published on:

  12. Dried blood spots (DBS) from fingertip prick blood can enable high throughput fatty acid profiling but may be prone to lipid peroxidation during storage. The use of butylated hydroxytoluene (BHT) on chromatogr...

    Authors: Adam H Metherel, Ryan C Hogg, Lindy M Buzikievich and Ken D Stark
    Citation: Lipids in Health and Disease 2013 12:22
    Content type: Research Published on:

  14. Sphingosine 1-phosphate (Sph-1-P), abundantly stored in platelets and released extracellularly upon activation, plays important roles as an extracellular mediator by interacting with specific cell surface rece...

    Authors: Yoshikazu Ono, Makoto Kurano, Ryunosuke Ohkawa, Hiromitsu Yokota, Koji Igarashi, Junken Aoki, Minoru Tozuka and Yutaka Yatomi
    Citation: Lipids in Health and Disease 2013 12:20
    Content type: Research Published on:

  15. Lipoprotein-associated phospholipase A2 activity (Lp-PLA2) is a good marker of cardiovascular risk in adults. It is strongly associated with stroke and many others cardiovascular events. Despite this, the impact ...

    Authors: Isis T da Silva, Anelise de Souza Timm and Nágila RT Damasceno
    Citation: Lipids in Health and Disease 2013 12:19
    Content type: Research Published on:

  16. Various mushrooms have been used in folk medicine for the treatment of lifestyle diseases in eastern countries, and several compounds that modulate the immune system, lower blood lipid levels, and inhibit tumo...

    Authors: Nao Inoue, Masashi Inafuku, Bungo Shirouchi, Koji Nagao and Teruyoshi Yanagita
    Citation: Lipids in Health and Disease 2013 12:18
    Content type: Research Published on:

  18. Microglia are considered the “resident macrophages” of the brain. When in their resting state, microglia perform routine maintenance and immune surveillance. Once activated, either by injury or an immune stimu...

    Authors: Lauren K Pettit, Christopher Varsanyi, James Tadros and Evros Vassiliou
    Citation: Lipids in Health and Disease 2013 12:16
    Content type: Research Published on:

  19. Type 1 diabetes (T1DM) is frequently accompanied by dyslipidemia related with insulin-dependent steps of the intravascular lipoprotein metabolism. T1DM dyslipidemia may predispose to precocious cardiovascular ...

    Authors: Alina C R Feitosa, Gilson S Feitosa-Filho, Fatima R Freitas, Bernardo L Wajchenberg and Raul C Maranhão
    Citation: Lipids in Health and Disease 2013 12:15
    Content type: Research Published on:

  20. Phytanic acid (PA) is a chlorophyll metabolite with potentials in regulating glucose metabolism, as it is a natural ligand of the peroxisome proliferator-activated receptor (PPAR) that is known to regulate hep...

    Authors: Brita N Che, Niels Oksbjerg, Lars I Hellgren, Jacob H Nielsen and Jette F Young
    Citation: Lipids in Health and Disease 2013 12:14
    Content type: Research Published on:

  21. This study was intended to explore the effect of extruded flaxseed meal supplemented diet on broiler growth performance, oxidative stability and organoleptic characteristics of broiler meat and meat products. ...

    Authors: Faqir Muhammad Anjum, Muhammad Faizan Haider, Muhammad Issa Khan, Muhammad Sohaib and Muhammad Sajid Arshad
    Citation: Lipids in Health and Disease 2013 12:13
    Content type: Research Published on:

  22. Previous experimental investigations have suggested that guaraná (Paullinia cupana Kunth, supplied by EMBRAPA Oriental) consumption is associated with a lower prevalence of cardiovascular metabolic diseases and h...

    Authors: Rafael de Lima Portella, Rômulo Pillon Barcelos, Edovando José Flores da Rosa, Euler Esteves Ribeiro, Ivana Beatrice Mânica da Cruz, Leila Suleiman and Felix Alexandre Antunes Soares
    Citation: Lipids in Health and Disease 2013 12:12
    Content type: Research Published on:

  23. Peroxisome proliferator activated receptor alpha (PPARα) ameliorates ethanol induced hepatic steatohepatitis. However, its role in alcoholic liver fibrosis has not been fully clarified. The aim of this study w...

    Authors: Yue-Min Nan, Ling-Bo Kong, Wei-Guang Ren, Rong-Qi Wang, Jing-Hua Du, Wen-Cong Li, Su-Xian Zhao, Yu-Guo Zhang, Wen-Juan Wu, Hai-Ling Di, Ya Li and Jun Yu
    Citation: Lipids in Health and Disease 2013 12:11
    Content type: Research Published on:

  24. Humans and rodents with impaired phytanic acid (PA) metabolism can accumulate toxic stores of PA that have deleterious effects on multiple organ systems. Ruminants and certain fish obtain PA from the microbial...

    Authors: Ann B Moser, Jody Hey, Patricia K Dranchak, Mazen W Karaman, Junsong Zhao, Laura A Cox, Oliver A Ryder and Joseph G Hacia
    Citation: Lipids in Health and Disease 2013 12:10
    Content type: Short report Published on:

  25. Statins are frequently administered to reduce low-density lipoprotein cholesterol (LDL-C) and vascular inflammation, because LDL-C and high sensitive C-reactive protein (hs-CRP) are associated with high risk f...

    Authors: Daisuke Yamazaki, Masaru Ishida, Hiroyuki Watanabe, Kiyoshi Nobori, Yasunori Oguma, Yutaka Terata, Takashi Koyama, Kenji Iino, Toshimitsu Kosaka and Hiroshi Ito
    Citation: Lipids in Health and Disease 2013 12:9
    Content type: Research Published on:

  26. Resveratrol (trans-3,4′,5-trihydroxystilbene) is a naturally occurring phytoalexin produced by plants in response to various stresses. Several studies have shown that resveratrol is present in significant amounts...

    Authors: Koji Nagao, Tomoyuki Jinnouchi, Shunichi Kai and Teruyoshi Yanagita
    Citation: Lipids in Health and Disease 2013 12:8
    Content type: Research Published on:

  27. The content of arachidonic acid in adipose tissue is positively associated with the risk of myocardial infarction, whereas the content of eicosapentaenoic acid in adipose tissue has been reported to be negativ...

    Authors: Michael S Nielsen, Marie-Louise M Grønholdt, Mogens Vyberg, Kim Overvad, Annette Andreasen, Karen-Margrete Due and Erik B Schmidt
    Citation: Lipids in Health and Disease 2013 12:7
    Content type: Research Published on:

  29. Lipid metabolism plays important roles in the whole process of pregnancy. Previous studies have demonstrated abnormalities of lipid metabolism in the placentas of pregnancies obtained by assisted reproductive ...

    Authors: Li-Ya Wang, Fang Le, Ning Wang, Lei Li, Xiao-Zhen Liu, Ying-Ming Zheng, Hang-Ying Lou, Xiang-Rong Xu, Yun-Long Chen, Xiao-Ming Zhu, He-Feng Huang and Fan Jin
    Citation: Lipids in Health and Disease 2013 12:5
    Content type: Research Published on:

  30. Dyslipidemia due to high total cholesterol, LDL-cholesterol, triglycerides, or low HDL-cholesterol is an important risk factor for coronary heart disease (CHD). Both SIRT1 and PUFAs can influence the expressio...

    Authors: Tomoko Inamori, Toshinao Goda, Nobuhiko Kasezawa and Kimiko Yamakawa-Kobayashi
    Citation: Lipids in Health and Disease 2013 12:4
    Content type: Research Published on:

  31. Researches have shown that soluble epoxide hydrolase inhibitors (sEHi) can protect against the development of atherosclerosis. Simultaneously, emerging evidences have implicated the association between fatty a...

    Authors: Xuan Zhao, Jian-qing Du, Dan-yan Xu and Shui-ping Zhao
    Citation: Lipids in Health and Disease 2013 12:3
    Content type: Research Published on:

  32. Fatty acid (FA) composition and desaturase indices are associated with obesity and related metabolic conditions. However, it is unclear to what extent desaturase activity in different lipid fractions contribut...

    Authors: Jonathan Cedernaes, Johan Alsiö, Åke Västermark, Ulf Risérus and Helgi B Schiöth
    Citation: Lipids in Health and Disease 2013 12:2
    Content type: Research Published on:

  33. Dyslipidemia increases circulating levels of oxidized low-density lipoprotein (OxLDL) and this may induce alveolar bone loss through toll-like receptor (TLR) 2 and 4. The purpose of this study was to investiga...

    Authors: Takaaki Tomofuji, Daisuke Ekuni, Tetsuji Azuma, Koichiro Irie, Yasumasa Endo, Kenta Kasuyama, Toshiki Yoneda and Manabu Morita
    Citation: Lipids in Health and Disease 2013 12:1
    Content type: Research Published on:

  34. The -493G/T polymorphism in the microsomal triglyceride transfer protein (MTP) gene is associated with lower serum low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels and longevity in seve...

    Authors: Shang-Ling Pan, Xiao-Qiu Luo, Ze-Ping Lu, Shao-Hua Lu, Huan Luo, Cheng-Wu Liu, Cai-You Hu, Ming Yang, Li-Li Du, Zhen Song, Guo-Fang Pang, Hua-Yu Wu, Jin-Bo Huang, Jun-Hua Peng and Rui-Xing Yin
    Citation: Lipids in Health and Disease 2012 11:177
    Content type: Research Published on:

  35. A novel herbal formulation LI10903F, alternatively known as LOWAT was developed based on its ability to inhibit adipogenesis and lipogenesis in 3T3-L1 adipocytes model. The clinical efficacy and tolerability o...

    Authors: Krishanu Sengupta, Atmatrana T Mishra, Manikeshwar K Rao, Kadainti VS Sarma, Alluri V Krishnaraju and Golakoti Trimurtulu
    Citation: Lipids in Health and Disease 2012 11:176
    Content type: Research Published on:

  36. On the basis that high fat diet induces inflammation in adipose tissue, we wanted to test the effect of dietary saturated and polysunsaturated fatty acids on human adipose tissue and adipocytes inflammation. M...

    Authors: Ravi Kumar Murumalla, Manoj Kumar Gunasekaran, Jibesh Kumar Padhan, Karima Bencharif, Lydie Gence, Franck Festy, Maya Césari, Régis Roche and Laurence Hoareau
    Citation: Lipids in Health and Disease 2012 11:175
    Content type: Research Published on:

  37. Evidence of the genetic association between CD36 candidate gene and the risk of metabolic syndrome and its components has been inconsistent. This case–control study assessed the haplotype-tagged SNPs from CD36 on...

    Authors: Kuo-Liong Chien, Hsiu-Ching Hsu, Pi-Hua Liu, Hung-Ju Lin and Ming-Fong Chen
    Citation: Lipids in Health and Disease 2012 11:174
    Content type: Research Published on:

  38. The molecular mechanism of how cells maintain cholesterol homeostasis has become clearer for the understanding of complicated association between sterol regulatory element-binding proteins (SREBPs), SREBP clea...

    Authors: Xiao-Ying Dong, Sheng-Qiu Tang and Jin-Ding Chen
    Citation: Lipids in Health and Disease 2012 11:173
    Content type: Review Published on:

  39. Beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on the lipid levels of dyslipidemic subjects are widely described in the literature. However, the underlying molecular mechanisms are large...

    Authors: Simone Schmidt, Janina Willers, Frank Stahl, Kai-Oliver Mutz, Thomas Scheper, Andreas Hahn and Jan Philipp Schuchardt
    Citation: Lipids in Health and Disease 2012 11:172
    Content type: Research Published on:

  40. In many types of cancer, prostaglandin E2 (PGE2) is associated with tumour related processes including proliferation, migration, angiogenesis and apoptosis. However in gliomas the role of this prostanoid is poorl...

    Authors: Renata N Gomes and Alison Colquhoun
    Citation: Lipids in Health and Disease 2012 11:171
    Content type: Research Published on:

  41. The objectives of the present study were to investigate the efficacy of the mixed culture of Lactobacillus acidophilus (DSM 20242), Bifidobacterium bifidum (DSM 20082) and Lactobacillus helveticus (CK60) in the f...

    Authors: Immaculata Oyeyemi Banjoko, Muinat Moronke Adeyanju, Oladipo Ademuyiwa, Olugbenga Obajimi Adebawo, Rahman Abiodun Olalere, Martin Oluseye Kolawole, Ibrahim Akorede Adegbola, Tope Adebusola Adesanmi, Tosin Oluyinka Oladunjoye, Adeyemi Adeola Ogunnowo, Ahmeed Adekola Shorinola, Oluwasetemi Daropale, Esther Bunmi Babatope, Adeboye Olufemi Osibogun, Deborah Tolulope Ogunfowokan, Temitope Adeola Jentegbe…
    Citation: Lipids in Health and Disease 2012 11:170
    Content type: Research Published on:

  42. Mitochondrial DNA damage, increased production of reactive oxygen species and progressive respiratory chain dysfunction, together with increased deposition of cholesterol and cholesteryl esters, are hallmarks ...

    Authors: Anne Marie Allen and Annette Graham
    Citation: Lipids in Health and Disease 2012 11:169
    Content type: Research Published on:

  43. Administration of androgens decreases plasma concentrations of high-density lipid cholesterol (HDL-C). However, the mechanisms by which androgens mediate lipid metabolism remain unknown. This present study use...

    Authors: Ye Yi-zhou, Cao Bing, Li Ming-qiu, Wang Wei, Wang Ru-xing, Rui Jun, Wei Liu-yan, Jing Zhao-hui, Ji Yong, Jiao Guo qing and Zou Jian
    Citation: Lipids in Health and Disease 2012 11:168
    Content type: Research Published on:

  45. The present study was performed to investigate the effects of the combination therapy of pinocembrin and simvastatin on the atherosclerotic lesions development in the ApoE−/− mice.

    Authors: Hui Sang, Na Yuan, Shutong Yao, Furong Li, Jiafu Wang, Yongqi Fang and Shucun Qin
    Citation: Lipids in Health and Disease 2012 11:166
    Content type: Research Published on:

  46. Given that acne is a rare condition in societies with higher consumption of omega-3 (n-3) relative to omega-6 (n-6) fatty acids, supplementation with n-3 may suppress inflammatory cytokine production and there...

    Authors: Golandam Khayef, Julia Young, Bonny Burns-Whitmore and Thomas Spalding
    Citation: Lipids in Health and Disease 2012 11:165
    Content type: Short report Published on:

  48. Accumulating evidence suggested that dysregulation of cholesterol homeostasis might be a major etiologic factor in initiating and promoting neurodegeneration in Alzheimer’s disease (AD). ATP-binding cassette t...

    Authors: Zhijie Xiao, Juan Wang, Weirong Chen, Peng Wang, Houlin Zeng and Weixi Chen
    Citation: Lipids in Health and Disease 2012 11:163
    Content type: Research Published on:

  49. Apolipoprotein (Apo) levels are considered more reliable than plasma lipoprotein levels for predicting coronary artery disease (CAD). However, a unanimous Apo marker for CAD has not been identified. In the Chi...

    Authors: Po-Yuan Chang, Chii-Ming Lee, Hsiu-Ching Hsu, Hung-Ju Lin, Kuo-Liong Chien, Ming-Fong Chen, Chu-Huang Chen, Yuan-Teh Lee and Chao-Yuh Yang
    Citation: Lipids in Health and Disease 2012 11:162
    Content type: Research Published on:

  50. Inflammation is increasingly recognized as being of both physiological and pathological importance in the immature brain. Cerebellar pathology occurs in autism, as a neurodevelopmental disorder with genetic an...

    Authors: Afaf El-Ansary and Laila Al-Ayadhi
    Citation: Lipids in Health and Disease 2012 11:160
    Content type: Research Published on:
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Lipids in Health and Disease

ISSN: 1476-511X