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  1. Atherosclerosis is associated with multiple genetic and modifiable risk factors. There is an increasing body of evidences to indicate that epigenetic mechanisms also play an essential role in atherogenesis by ...

    Authors: Shuyu Zhou, Zhizhong Zhang and Gelin Xu
    Citation: Lipids in Health and Disease 2014 13:134
    Content type: Review Published on:

  2. The prognosis for hyper-high-density lipoprotein (HDL) cholesterolemic patients has not been fully elucidated. We conducted a post hoc analysis of MEGA study data to investigate prospectively the incidence of ...

    Authors: Haruo Nakamura and Kyoichi Mizuno
    Citation: Lipids in Health and Disease 2014 13:133
    Content type: Research Published on:

  3. Twist 1 is highly expressed in adipose tissue and has been associated with obesity and related disorders. However, the molecular function of Twist 1 in adipose tissue is unclear. Twist 1 has been implicated in...

    Authors: Wanshan Ma, Sumei Lu, Tao Sun, Xiangdong Wang, Yongmei Ma, Xiaoli Zhang, Ruxing Zhao and Yunshan Wang
    Citation: Lipids in Health and Disease 2014 13:132
    Content type: Research Published on:

  4. Hyperlipidemia, a metabolic disorder of lipids, is a well known risk factor of cardiovascular events and metabolic syndrome. In this study, the in vivo lipid-lowering activity of the triterpene (Methyl-3β-hydroxy...

    Authors: Kgothatso E Machaba, Sinazo Z Z Cobongela, Rebamang A Mosa, Lawal A Oladipupo, Trayana G Djarova and Andy R Opoku
    Citation: Lipids in Health and Disease 2014 13:131
    Content type: Research Published on:

  5. Hepatitis B virus (HBV) infection poses a serious threat to human health, with China being one of the highly affected countries. However, the pathogenesis of chronic hepatitis B (CHB) is still unclear. Apolipo...

    Authors: Weichao Jiang, Lei Zheng, Qianqian Yang, Zhouying Huang and Xiaobei Wang
    Citation: Lipids in Health and Disease 2014 13:130
    Content type: Research Published on:

  6. Metabolic syndrome (MS) increases a risk of developing cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). The Vitamin D Receptor gene (VDR) may be important for developing MS. The aim of this st...

    Authors: Yi Zhao, Sha Liao, Jun He, Yanan Jin, Hailong Fu, Xiaoying Chen, Xuemin Fan, Hongxia Xu, Xiuying Liu, Jing Jin and Yuhong Zhang
    Citation: Lipids in Health and Disease 2014 13:129
    Content type: Research Published on:

  7. Although hypercholesterolemia is a major risk factor for coronary artery disease (CAD), only limited data are available regarding its direct effect on myocardial function apart from CAD. The aim of this study ...

    Authors: Liyun Liu, Yuming Mu, Wei Han and Chunmei Wang
    Citation: Lipids in Health and Disease 2014 13:128
    Content type: Research Published on:

  8. The effects of fish oil supplements on lipid profile in dialysis patients are controversial. With increasing interest in the potential health benefits of fish oil, it is important to explore its real effects.

    Authors: Wei Zhu, Chongya Dong, Han Du, He Zhang, Jie Chen, Xiaohong Hu and Feng Hu
    Citation: Lipids in Health and Disease 2014 13:127
    Content type: Review Published on:

  9. The CYP7A1 gene polymorphism has been reported to be associated with gallbladder stone disease (GSD) and serum lipid levels, but the results were inconsistent. This meta-analysis aimed to evaluate the influence o...

    Authors: Qiang Cai, Zhen-Qiang Wang, Qu Cai, Chen Li, Er-Zhen Chen and Zhao-Yan Jiang
    Citation: Lipids in Health and Disease 2014 13:126
    Content type: Research Published on:

  10. Cardiovascular diseases have become the leading cause of death from chronic diseases in the world. Main risk factors include hypercholesterolemia, which is caused in most cases by a high saturated fat diet. Pl...

    Authors: Elsa M Vásquez-Trespalacios and Johanna Romero-Palacio
    Citation: Lipids in Health and Disease 2014 13:125
    Content type: Research Published on:

  11. Previous studies reported the relation between MTLRP genetic polymorphism and type 2 diabetes, however, the conclusion were conflicting. In the present study, we performed a meta-analysis to reveal this associati...

    Authors: Li-Li Chen, Song-Mei Han, Fei-Fei Tang and Qiang Li
    Citation: Lipids in Health and Disease 2014 13:124
    Content type: Research Published on:

  12. A previous genome-wide association study has displayed the association of the ST3 beta-galactoside alpha-2,3-sialytransferase 4 (ST3GAL4) gene variant and lipid traits in the individuals of European ancestry, ...

    Authors: Quan-Zhen Lin, Rui-Xing Yin, Tao Guo, Jian Wu, Jia-Qi Sun, Shao-Wen Shen, Guang-Yuan Shi, Jin-Zhen Wu, Cheng-Wu Liu and Shang-Ling Pan
    Citation: Lipids in Health and Disease 2014 13:123
    Content type: Research Published on:

  13. In China, even though the prevalence of dyslipidemia among adults increased yearly and dyslipidemia being an important risk factor for cardiovascular diseases among the Chinese population, however, the awarene...

    Authors: Huan He, Ya-qin Yu, Yong Li, Chang-gui Kou, Bo Li, Yu-chun Tao, Qing Zhen, Chang Wang, Joseph Sam Kanu, Xu-feng Huang, Mei Han and Ya-wen Liu
    Citation: Lipids in Health and Disease 2014 13:122
    Content type: Research Published on:

  14. Supplementation with a phosphatidylserine and phosphatidylserine/ phosphatidic acid complex (PAS) has been observed to normalize stress induced dysregulations of the hypothalamus-pituitary-adrenal axis (HPAA)....

    Authors: Juliane Hellhammer, Dominic Vogt, Nadin Franz, Ulla Freitas and David Rutenberg
    Citation: Lipids in Health and Disease 2014 13:121
    Content type: Research Published on:

  15. High sensitivity C-reactive protein (Hs-CRP) and adiponectin (APN) are two critical cytokines and exert inverse effects on atherosclerosis initiation and progression. The purpose of our study was to investigat...

    Authors: Huocheng Liao, Zhiming Li, Dongdan Zheng, Jianping Liu, Yan Liu, Chun Xiao and Hongguang Wang
    Citation: Lipids in Health and Disease 2014 13:120
    Content type: Research Published on:

  16. Corticosteroids have been extensively used in the treatment of immunological reactions and neuritis in leprosy. The present study evaluates the serological response to steroid treatment in leprosy reactions an...

    Authors: Renuka Raju, Sujai Suneetha, Rupendra S Jadhav, MeherVani Chaduvula, Sara Atkinson, Suman Jain, Leo H Visser, Loretta Das, Ravindra Panhalkar, Vidyagouri Shinde, Parphananda P Reddy, Pramila Barkataki, Diana NJ Lockwood, Wim H Van Brakel and Lavanya M Suneetha
    Citation: Lipids in Health and Disease 2014 13:119
    Content type: Research Published on:

  17. Dysregulations in cholesterol and lipid metabolism have been linked to human diseases like hypercholesterolemia, atherosclerosis or the metabolic syndrome. Many ABC transporters are involved in trafficking of ...

    Authors: Patricia Kuzaj, Joachim Kuhn, Mareike Dabisch-Ruthe, Isabel Faust, Christian Götting, Cornelius Knabbe and Doris Hendig
    Citation: Lipids in Health and Disease 2014 13:118
    Content type: Research Published on:

  18. Increased serum uric acid (SUA) is associated with dyslipidemia. However, there are conflicting data about the role of single lipid species including non-high density lipoprotein cholesterol (non-HDL-C) in pro...

    Authors: Juan Xu, Hao Peng, Qinghua Ma, Xiaohua Zhou, Wenxin Xu, Liang Huang, Jiarong Hu and Yonghong Zhang
    Citation: Lipids in Health and Disease 2014 13:117
    Content type: Research Published on:

  19. Hypertriglyceridemia (HTG) is defined as a triglyceride (TG) plasma level exceeding 150 mg/dl and is tightly associated with atherosclerosis, metabolic syndrome, obesity, diabetes and acute pancreatitis. The p...

    Authors: Grégory Ehx, Stéphanie Gérin, Grégory Mathy, Fabrice Franck, Helena C F Oliveira, Anibal E Vercesi and Francis E Sluse
    Citation: Lipids in Health and Disease 2014 13:116
    Content type: Research Published on:

  20. Rho kinase over-activation is associated with nitric oxide (NO) reduction and atherosclerosis. Metformin is favorable for endothelial function improvement and cardiovascular outcomes. Whether cardio-protective...

    Authors: Yan Liu, Congwu Huang, Chuan Ceng, Haiyong Zhan, Dongdan Zheng and Weixing Han
    Citation: Lipids in Health and Disease 2014 13:115
    Content type: Research Published on:

  21. Owing to the complexity of the antioxidant materials and their mechanism of actions, it is obvious that no single testing method is capable of providing a comprehensive picture of the antioxidant profile. The ...

    Authors: Guesmi Fatma, Ben Farhat Mouna, Mejri Mondher and Landoulsi Ahmed
    Citation: Lipids in Health and Disease 2014 13:114
    Content type: Research Published on:

  22. Body adiposity, especially ectopic fat accumulation, has a range of metabolic and cardiovascular effects. The aim of this study was to investigate the association between head fat and metabolic values in Chine...

    Authors: Xing-chun Wang, Huan Liu, Yue-ye Huang, Hang Sun, Le Bu and Shen Qu
    Citation: Lipids in Health and Disease 2014 13:113
    Content type: Research Published on:

  23. We aimed to comprehensively evaluate lipoprotein profile including lipid particle size following a lifestyle intervention in metabolic syndrome (MetS) volunteers and to assess the associations between lipoprot...

    Authors: Frédéric Dutheil, Guillaume Walther, Robert Chapier, George Mnatzaganian, Bruno Lesourd, Geraldine Naughton, Julien Verney, Anne Fogli, Vincent Sapin, Martine Duclos, Agnès Vinet, Philippe Obert, Daniel Courteix and Gérard Lac
    Citation: Lipids in Health and Disease 2014 13:112
    Content type: Research Published on:

  24. Free fatty acids (FFA), oxidized low-density lipoprotein (LDL) and its antibodies, lipid profile markers, which are formed under oxidative stress, play an important role in atherosclerotic disease. Assess the ...

    Authors: Olga Gruzdeva, Evgenya Uchasova, Yulia Dyleva, Ekaterina Belik, Victoria Karetnikova, Alexander Shilov and Olga Barbarash
    Citation: Lipids in Health and Disease 2014 13:111
    Content type: Research Published on:

  26. Epidemiological studies have found a U-shaped relationship between serum phosphorus and cardiovascular disease (CVD). The mechanism(s) behind such a relationship are poorly understood. Phosphorus (P) is report...

    Authors: Jana Hazim, Sani Hlais, Hala Ghattas, Dareen Shatila, Maya Bassil and Omar Obeid
    Citation: Lipids in Health and Disease 2014 13:109
    Content type: Short report Published on:

  27. Visceral adiposity index (VAI), a novel sex-specific index for visceral fat measurement, has been proposed recently. We evaluate the efficacy of VAI in identifying diabetes risk in Chinese people, and compare ...

    Authors: Chen Chen, Yan Xu, Zhi-rong Guo, Jie Yang, Ming Wu and Xiao-shu Hu
    Citation: Lipids in Health and Disease 2014 13:108
    Content type: Research Published on:

  28. Flaxseed oil has the highest concentration of omega-3 α-linolenic acid, which has been associated with cardiovascular benefit. However, the mechanism underlying the vascular effects induced through flaxseed oi...

    Authors: Dieli Oliveira Nunes, Camila Cruz Pereira Almenara, Gilson Brás Broseghini-Filho, Marito Afonso Sousa Costa Silva, Ivanita Stefanon, Dalton V Vassallo and Alessandra S Padilha
    Citation: Lipids in Health and Disease 2014 13:107
    Content type: Research Published on:

  29. Obesity is characterized by a chronic low-grade inflammation and altered stress responses in key metabolic tissues. Impairment of heat shock response (HSR) has been already linked to diabetes and insulin resis...

    Authors: Ali Tiss, Abdelkrim Khadir, Jehad Abubaker, Mohamed Abu-Farha, Irina Al-Khairi, Preethi Cherian, Jeena John, Sina Kavalakatt, Samia Warsame, Fahad Al-Ghimlas, Naser Elkum, Kazem Behbehani, Said Dermime and Mohammed Dehbi
    Citation: Lipids in Health and Disease 2014 13:106
    Content type: Research Published on:

  30. The aim of this study was to investigate the variation of platelet-activating factor acetylhydrolase (PAF-AH) in patients with various stages of hepatitis B infection and evaluate the association between PAF-A...

    Authors: Limin Feng, Ying Zhao, Guofang Feng and Yu Chen
    Citation: Lipids in Health and Disease 2014 13:105
    Content type: Research Published on:

  31. Variants in the Methylenetetrahydrofolate reductase (MTHFR) gene may result in a lowered catalytic activity and associate with subsequent elevated serum homocysteine (Hcy) concentration, abnormal DNA synthesis...

    Authors: Ning-Yuan Chen, Cheng-Wu Liu, Li-Li Du, Li-Ping Xiao, Lin Ge, Yi-Yuan Wang, Zhen Wei, Hua-Yu Wu, Chen-Yuan Luo, Liang Liang, Jun-Hua Peng, Xiao-Qiu Luo, Rui-Xing Yin, Cuc Phuong Nguyen and Shang-Ling Pan
    Citation: Lipids in Health and Disease 2014 13:104
    Content type: Research Published on:

  33. Vegetables and fruits are rich in vitamins, minerals and, dietary fiber and contribute to the prevention and improvement of obesity and metabolic syndrome. However, inadequate intake of vegetable and fruit is ...

    Authors: Izumi Aiso, Hiroko Inoue, Yukiko Seiyama and Toshiko Kuwano
    Citation: Lipids in Health and Disease 2014 13:102
    Content type: Research Published on:

  34. Numerous studies have investigated the effects of isolated CLA supplementation on glucose homeostasis in humans and rodents. However, both the amount and relative abundance of CLA isomers in supplemental form ...

    Authors: Amanda Stefanson, Loren E Hopkins, Ousama AlZahal, Ian R Ritchie, Tara MacDonald, David C Wright, Brian W McBride and David J Dyck
    Citation: Lipids in Health and Disease 2014 13:101
    Content type: Research Published on:

  35. Nonalcoholic steatohepatitis (NASH) carries an increased risk of cardiovascular disease (CVD) relative to the general population. We sought to evaluate whether differences in lipoprotein subfractions in obese ...

    Authors: Kathleen E Corey, Joseph Misdraji, Lou Gelrud, Hui Zheng, Raymond T Chung and Ronald M Krauss
    Citation: Lipids in Health and Disease 2014 13:100
    Content type: Short report Published on:

  36. Omega-3 fatty acids confer beneficial health effects, but North Americans are lacking in their dietary omega-3-rich intake. Supplementation is an alternative to consumption of fish; however, not all omega-3 pr...

    Authors: Maggie Laidlaw, Carla A Cockerline and William J Rowe
    Citation: Lipids in Health and Disease 2014 13:99
    Content type: Research Published on:

  37. 3-Hydroxy-3-methyl-glutaryl CoA (HMG-CoA) reductase inhibitors or statins are competitive inhibitors of the rate-limiting enzyme in cholesterol biosynthesis. Currently, statins are used as first-line therapy i...

    Authors: Zhi-yu Chen, Shuai-nan Liu, Cai-na Li, Su-juan Sun, Quan Liu, Lei Lei, Li-hui Gao and Zhu-fang Shen
    Citation: Lipids in Health and Disease 2014 13:98
    Content type: Research Published on:

  38. We recently showed that a combined deficiency of iron (ID) and n-3 fatty acids (n-3 FAD) in rats disrupts brain monoamine metabolism and produces greater memory deficits than ID or n-3 FAD alone. Providing the...

    Authors: Jeannine Baumgartner, Cornelius M Smuts and Michael B Zimmermann
    Citation: Lipids in Health and Disease 2014 13:97
    Content type: Research Published on:

  39. Breast cancer is attributable to modifiable risk factors including the intake of dietary n-3 polyunsaturated fatty acids (PUFA). A key piece of evidence, yet to be addressed, that would demonstrate a causal re...

    Authors: Michael A Leslie, Salma A Abdelmagid, Kate Perez, William J Muller and David WL Ma
    Citation: Lipids in Health and Disease 2014 13:96
    Content type: Research Published on:

  40. Major cardiovascular disorders are being recognized earlier in life. In this study we examined the effects of swimming and soccer training on male adolescent lipid-lipoprotein profiles relative to a maturity m...

    Authors: Majid S Koozehchian, Farzad Nazem, Richard B Kreider, William J Roberts, Thomas M Best, Yi Rong and Li Zuo
    Citation: Lipids in Health and Disease 2014 13:95
    Content type: Research Published on:

  41. Abnormal lipids is one of the critical risk factors for myocardial infarction (MI), however the role of genetic variants in lipid metabolism-related genes on MI pathogenesis still requires further investigatio...

    Authors: Shun Xu, Jie Cheng, Yu-ning Chen, Keshen Li, Ze-wei Ma, Jin-ming Cen, Xinguang Liu, Xi-li Yang, Can Chen and Xing-dong Xiong
    Citation: Lipids in Health and Disease 2014 13:94
    Content type: Research Published on:

  42. Although the association between the apolipoprotein A5 (APOA5) genetic variants and hypertriglyceridemia has been extensively studied, there have been few studies, particularly in children and adolescents, on the...

    Authors: Wei-fen Zhu, Chun-lin Wang, Li Liang, Zheng Shen, Jun-fen Fu, Pei-ning Liu, Lan-qiu Lv and Yi-min Zhu
    Citation: Lipids in Health and Disease 2014 13:93
    Content type: Research Published on:

  43. The conversions of the n-3 and n-6 fatty acid of plant origin to the C20 and C22 very long chain fatty acids (LCPUFAs) is regulated by several cellular enzymes such as elongases and desaturases.

    Authors: Anna Haug, Nicole F Nyquist, Magny Thomassen, Arne T Høstmark and Tone-Kari Knutsdatter Østbye
    Citation: Lipids in Health and Disease 2014 13:92
    Content type: Research Published on:

  44. Probucol has been shown to prevent cerebral capillary disturbances characterized by blood-to-brain extravasation of plasma derived proteins and neurovascular inflammation in mice maintained on western-styled d...

    Authors: Ryusuke Takechi, Menuka M Pallebage-Gamarallage, Virginie Lam, Corey Giles and John CL Mamo
    Citation: Lipids in Health and Disease 2014 13:91
    Content type: Research Published on:

  45. Persistent immune activation and inflammation are lying behind HIV-infection even in the setting of ART mediated viral suppression. The purpose of this study is to define the in vivo effect of two first-line ART ...

    Authors: Vasiliki D Papakonstantinou, Maria Chini, Nikos Mangafas, George M Stamatakis, Nickolaos Tsogas, Alexandros B Tsoupras, Katherina Psarra, Elizabeth Fragopoulou, Smaragdi Antonopoulou, Panagiotis Gargalianos, Constantinos A Demopoulos and Marios-C Lazanas
    Citation: Lipids in Health and Disease 2014 13:90
    Content type: Research Published on:

  46. Glycosylated hemoglobin A1C (HbA1c) has been widely recognized as a marker for predicting the severity of diabetes mellitus (DM) and several cardiovascular diseases. However, whether HbA1c could predict the se...

    Authors: Li-Feng Hong, Xiao-Lin Li, Yuan-Lin Guo, Song-Hui Luo, Cheng-Gang Zhu, Ping Qing, Rui-Xia Xu, Na-Qiong Wu and Jian-Jun Li
    Citation: Lipids in Health and Disease 2014 13:89
    Content type: Research Published on:

  47. Ivy gourd (Coccinia grandis L. Voigt) is a tropical plant widely distributed throughout Asia, Africa, and the Pacific Islands. The anti-obesity property of this plant has been claimed but still remains to be scie...

    Authors: Ruthaiwan Bunkrongcheap, Nongporn Hutadilok-Towatana, Kusumarn Noipha, Chatchai Wattanapiromsakul, Masashi Inafuku and Hirosuke Oku
    Citation: Lipids in Health and Disease 2014 13:88
    Content type: Research Published on:

  48. The over-all age-adjusted prevalence of diabetes mellitus type 2 (DMT2) in Saudi Arabia is unprecedented at 31%. Aggressive measures should be done to curb down increasing incidence. In this prospective 6-mont...

    Authors: Nasser M Al-Daghri, Hanan Alfawaz, Naji J Aljohani, Yousef Al-Saleh, Kaiser Wani, Abdullah M Alnaami, Mohammad Alharbi and Sudhesh Kumar
    Citation: Lipids in Health and Disease 2014 13:87
    Content type: Research Published on:

  49. Omega-3 (n-3) polyunsaturated fatty acid (PUFA) consumption increases low-density lipoprotein (LDL) cholesterol (C) concentrations and particle size. Studies showed that individuals with large, buoyant LDL par...

    Authors: Catherine Ouellette, Iwona Rudkowska, Simone Lemieux, Benoit Lamarche, Patrick Couture and Marie-Claude Vohl
    Citation: Lipids in Health and Disease 2014 13:86
    Content type: Research Published on:

  50. Studies had investigated the relationships between endothelial lipase (EL) 584C/T polymorphism and high density lipoprotein cholesterol (HDL-C) level and coronary heart disease (CHD), but the results were cont...

    Authors: Gaojun Cai, Zhiying Huang, Bifeng Zhang, Weijin Weng and Ganwei Shi
    Citation: Lipids in Health and Disease 2014 13:85
    Content type: Research Published on:
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Lipids in Health and Disease

ISSN: 1476-511X