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  1. Mice that lack acyl CoA:diacylglycerol acyltransferase (Dgat1-/- mice) are reported to have a reduced body fat content and improved glucose tolerance and insulin sensitivity. Studies so far have focussed on male ...

    Authors: Steven JY Wang, Claire Cornick, Jacqueline O'Dowd, Michael A Cawthorne and Jonathan R S Arch

    Citation: Lipids in Health and Disease 2007 6:2

    Content type: Research

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  2. Cardiovascular disease (CVD) is the Nation's leading killer for both men and women among all racial and ethnic groups. Development and progression of CVD is linked to the presence of risk factors such as hyper...

    Authors: Danik M Martirosyan, Lidia A Miroshnichenko, Svetlana N Kulakova, Ala V Pogojeva and Vladimir I Zoloedov

    Citation: Lipids in Health and Disease 2007 6:1

    Content type: Research

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  3. Severe combined hyperlipidaemia has occasionally been associated with infiltration of tissues in addition to arteries and the skin. We report a woman with Type 2 diabetes mellitus (DM) and severe combined hype...

    Authors: Rachel A Davey, Niall C Tebbutt, Jenny M Favaloro, David N O'Neal, Derek Rae, Jeffrey D Zajac and James D Best

    Citation: Lipids in Health and Disease 2006 5:29

    Content type: Short paper

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  4. Alzheimer's disease and type 2 diabetes mellitus tend to occur together. We sought to identify protein(s) common to both conditions that could suggest a possible unifying pathogenic role. Using human neuronal ...

    Authors: Appa Rao Allam, Gumpeny Ramachandra Sridhar, Hanuman Thota, Changalasetty Suresh Babu, Akula Siva Prasad and Ch Divakar

    Citation: Lipids in Health and Disease 2006 5:28

    Content type: Short paper

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  5. The lipodystrophic syndrome (LD) is a disorder resulting from selective damage of adipose tissue by antiretroviral drugs included in therapy controlling human-immunodeficiency-virus-1. In the therapy cocktail ...

    Authors: Christel Gentil, Sébastien Le Jan, Josette Philippe, Jacques Leibowitch, Pierre Sonigo, Stéphane Germain and France Piétri-Rouxel

    Citation: Lipids in Health and Disease 2006 5:27

    Content type: Research

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  6. The glycosphingolipid sulfatide has previously been found in several mammalian tissues, but information on the uptake of exogenously administered sulfatide in different organs in vivo is limited. In pancreatic be...

    Authors: Maria Blomqvist, Thomas Osterbye, Jan-Eric Månsson, Karsten Buschard and Pam Fredman

    Citation: Lipids in Health and Disease 2006 5:26

    Content type: Research

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  7. It has been shown that calcifying vesicles play an important role in aortic calcification and that cholesterol content in the isolated vesicle fraction is increased when rabbits are fed supplemental cholestero...

    Authors: Howard HT Hsu and Nathan C Culley

    Citation: Lipids in Health and Disease 2006 5:25

    Content type: Research

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  8. Once considered a problem of developed countries, obesity and obesity-related complications (such as metabolic syndrome) are rapidly spreading around the globe. The purpose of the present study was to investig...

    Authors: Julius Oben, Dieudonne Kuate, Gabriel Agbor, Claudia Momo and Xavio Talla

    Citation: Lipids in Health and Disease 2006 5:24

    Content type: Research

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  9. Triacylglyerol-rich very low density lipoprotein (VLDL) particles are the primary carriers of fatty acids in the circulation and as such serve as a rich energy source for peripheral tissues. Receptor-mediated ...

    Authors: Larissa C Wilsie, Amanda M Gonzales and Robert A Orlando

    Citation: Lipids in Health and Disease 2006 5:23

    Content type: Research

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  10. HMG-CoA reductase and the LDL receptor are ubiquitously expressed in major tissues. Since the liver plays a major role in regulating circulating LDL, it is usually of interest to measure the effects of drug or...

    Authors: Dimple Aggarwal, Hedley C Freake, Ghada A Soliman, Amrita Dutta and Maria-Luz Fernandez

    Citation: Lipids in Health and Disease 2006 5:22

    Content type: Short paper

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  11. Arylsulfatase A (ASA)-deficient mice are a model for the lysosomal storage disorder metachromatic leukodystrophy. This lipidosis is characterised by the lysosomal accumulation of the sphingolipid sulfatide. St...

    Authors: S Franken, D Wittke, JE Mansson, R D'Hooge, PP De Deyn, R Lüllmann-Rauch, U Matzner and V Gieselmann

    Citation: Lipids in Health and Disease 2006 5:21

    Content type: Research

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  12. Adaptation of assays on dried blood has advantages of ease of collection, transportation, minimal invasiveness and requirement of small volume. A method for extraction and estimation of triglyceride from blood...

    Authors: Rizwana Quraishi, Ramakrishnan Lakshmy, Dorairaj Prabhakaran, Ashok Kumar Mukhopadhyay and Bansilal Jailkhani

    Citation: Lipids in Health and Disease 2006 5:20

    Content type: Short paper

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  13. Lipoprotein Lipase (LPL), a key enzyme in lipid metabolism, catalyzes the hydrolysis of triglycerides (TG) from TG-rich lipoproteins, and serves a bridging function that enhances the cellular uptake of lipopro...

    Authors: Shu-Fen Wung, Medha V Kulkarni, Clive R Pullinger, Mary J Malloy, John P Kane and Bradley E Aouizerat

    Citation: Lipids in Health and Disease 2006 5:19

    Content type: Research

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  14. Vascular calcification is implicated in myocardial infarction, instability and rigidity of the aortic wall, and bioprosthetic failures. Although an increase in the calcium (Ca) content in atherogenic diets has...

    Authors: Howard HT Hsu and Nathan C Culley

    Citation: Lipids in Health and Disease 2006 5:16

    Content type: Research

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  15. Tegaserod is effective in treating IBS patients with constipation, and does not alter gallbladder motility in healthy individuals or in patients with IBS. However, it is not known if tegaserod affects the bili...

    Authors: Ronald Mathison, Eldon Shaffer, Hans-Juergen Pfannkuche and David Earnest

    Citation: Lipids in Health and Disease 2006 5:15

    Content type: Research

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  16. Hyperlipidemia is a major risk factor in etiology of cardiovascular disease. Previous studies have shown association between vegetarian diet and low total serum cholesterol as well as LDL-cholesterol which is ...

    Authors: Olugbenga Adebawo, Bamidele Salau, Esther Ezima, Olamilekan Oyefuga, Emmanuel Ajani, Gbolahan Idowu, Adekunle Famodu and Odutola Osilesi

    Citation: Lipids in Health and Disease 2006 5:14

    Content type: Research

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  17. A new water-based topical formulation is presented that aims at providing good penetration properties for both lipophilic and hydrophilic drugs with as small a disturbance of the skin barrier function as possi...

    Authors: Mats Silvander, Lovisa Ringstad, Ruby Ghadially and Thomas Sköld

    Citation: Lipids in Health and Disease 2006 5:12

    Content type: Research

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  18. Apolipoprotein AV (ApoAV) gene variant, -1131T>C, is associated with increased triglyceride concentrations in all ethnic groups studied. An MseI based RFLP analysis is the most commonly used method for genotyping...

    Authors: Kirsten J Ward, Sian Ellard, Chittaranjan S Yajnik, Timothy M Frayling, Andrew T Hattersley, Prathyusha NS Venigalla and Giriraj R Chandak

    Citation: Lipids in Health and Disease 2006 5:11

    Content type: Research

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  19. Herein, we expand our previous work on the effects of long chain polyunsaturated fatty acids (LC-PUFA) on the murine hepatic transcriptome using novel statistical and bioinformatic approaches for evaluating mi...

    Authors: Alvin Berger, Matthew A Roberts and Bruce Hoff

    Citation: Lipids in Health and Disease 2006 5:10

    Content type: Research

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  20. previous studies have indicated on association between shift work and lipid profile disturbances. Lipid profile disturbances could be due to internal desynchronization. The aim of this study was to analyze whe...

    Authors: Masoumeh Ghiasvand, Ramin Heshmat, Reza Golpira, Vahid Haghpanah, Ali Soleimani, Payman Shoushtarizadeh, Seyed Mohammad Tavangar and Bagher Larijani

    Citation: Lipids in Health and Disease 2006 5:9

    Content type: Research

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  21. The Friedewald formula (LDL-F) for the estimation of low-density lipoprotein (LDL) cholesterol concentrations is the most often used formula in clinical trials and clinical practice. However, much concern has ...

    Authors: Irene Gazi, Vasilis Tsimihodimos, Theodosios D Filippatos, Vasilios G Saougos, Eleni T Bairaktari, Alexandros D Tselepis and Moses Elisaf

    Citation: Lipids in Health and Disease 2006 5:8

    Content type: Research

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  22. There is an increase in obesity among the population of industrialized countries, and dietary supplementation with Conjugated Linoleic Acid (CLA) has been reported to lower body fat mass. However, weight loss ...

    Authors: Jameela Banu, Arunabh Bhattacharya, Mizanur Rahman, Marianne O'Shea and Gabriel Fernandes

    Citation: Lipids in Health and Disease 2006 5:7

    Content type: Research

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  23. A high dietary intake of n-6 compared to n-3 fatty acids (FAs) may promote the production of pro-inflammatory eicosanoids and cytokines. In two recent studies, short-term (10-day) duodenal administration of n-...

    Authors: Tormod Bjørkkjær, Johan G Brun, Merete Valen, Gülen Arslan, Ragna Lind, Linn A Brunborg, Arnold Berstad and Livar Frøyland

    Citation: Lipids in Health and Disease 2006 5:6

    Content type: Research

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  24. The strong causal role of hypercholesterolaemia on the progression of atherosclerosis and subsequently on the development of cardiovascular disease is well described. Main aim of this study was to evaluate the...

    Authors: George A Milias, Demosthenes B Panagiotakos, Christos Pitsavos, Dimitra Xenaki, George Panagopoulos and Christodoulos Stefanadis

    Citation: Lipids in Health and Disease 2006 5:5

    Content type: Research

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  25. Liver plays a key role in the metabolism of plasma apolipoproteins, endogenous lipids and lipoproteins. Hepatocellular carcinoma (HCC) is one of the most common fatal malignant tumors in China and in other Sou...

    Authors: Jingting Jiang, Peter Nilsson-Ehle and Ning Xu

    Citation: Lipids in Health and Disease 2006 5:4

    Content type: Review

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  26. The heart is rich in cardiolipin, a phospholipid acylated in four sites, predominately with linoleic acid. Whether or not aging alters the composition of cardiolipin acyl chains is controversial. We therefore ...

    Authors: Ho-Joo Lee, Jana Mayette, Stanley I Rapoport and Richard P Bazinet

    Citation: Lipids in Health and Disease 2006 5:2

    Content type: Research

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  27. Homocysteine is an independent risk factor for cardiovascular diseases. It is also known to be associated with a variety of complex disorders. While there are a large number of independent studies implicating ...

    Authors: Priyanka Sharma, RD Senthilkumar, Vani Brahmachari, Elayanambi Sundaramoorthy, Anubha Mahajan, Amitabh Sharma and Shantanu Sengupta

    Citation: Lipids in Health and Disease 2006 5:1

    Content type: Review

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  28. Dietary intervention trials rely on self-reported measures of intake for assessment of energy and macronutrient composition. Dietary fat intake is of particular interest due to strong associations with pathoph...

    Authors: Sally D Poppitt, Paul Kilmartin, Paul Butler and Geraldine F Keogh

    Citation: Lipids in Health and Disease 2005 4:30

    Content type: Research

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  29. 13-Methyltetradecanoic acid (13-MTD), an iso-C15 branched- chain saturated fatty acid, has been shown to induce apoptotic cell death of numerous human cancer cells. However, the mechanism for the induction of ...

    Authors: Sawitree Wongtangtintharn, Hirosuke Oku, Hironori Iwasaki, Masashi Inafuku, Takayoshi Toda and Teruyoshi Yanagita

    Citation: Lipids in Health and Disease 2005 4:29

    Content type: Research

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  30. Cholesterol ester storage disease (CESD) is an autosomal recessive illness that results from mutations in the LIPA gene encoding lysosomal acid lipase. CESD patients present in childhood with hepatomegaly and dys...

    Authors: Venu T Tadiboyina, Dora M Liu, Brooke A Miskie, Jian Wang and Robert A Hegele

    Citation: Lipids in Health and Disease 2005 4:26

    Content type: Research

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  31. Oxidative modification of low-density lipoprotein (LDL) is a key event in the oxidation hypothesis of atherogenesis. Some in vitro experiments have previously suggested that high-density lipoprotein (HDL) co-incu...

    Authors: T Solakivi, O Jaakkola, A Salomäki, N Peltonen, S Metso, T Lehtimäki, H Jokela and ST Nikkari

    Citation: Lipids in Health and Disease 2005 4:25

    Content type: Research

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  32. Postprandial lipemia is an independent risk factor for coronary heart disease. Single bouts of moderate exercise may lower this risk, but the minimum duration of moderate intensity exercise that still lowers p...

    Authors: Martina Pfeiffer, Tanja Ludwig, Caspar Wenk and Paolo C Colombani

    Citation: Lipids in Health and Disease 2005 4:24

    Content type: Research

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  33. In man, elevated levels of plasma lipoprotein (a)(Lp(a)) is a cardiovascular risk factor, and oxidized phospholipids are believed to play a role as modulators of inflammatory processes such as atherosclerosis....

    Authors: Knut A Eliassen, Bjørn P Brodal, Aud Svindland, Harald Osmundsen, Helle Rønning, Srdjan Djurovic and Kåre Berg

    Citation: Lipids in Health and Disease 2005 4:23

    Content type: Research

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  34. In the present study, the effects of subchronic treatments (4 weeks) of hypercholesterolemic (single) and diabetic-hypercholesterolemic (combined) rats with 4 (3H) quinazolinone and 2 halogenated derivatives (...

    Authors: Fawzia M Refaie, Amr Y Esmat, Soad M Abdel Gawad, Aida M Ibrahim and Mona A Mohamed

    Citation: Lipids in Health and Disease 2005 4:22

    Content type: Research

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  35. The metabolic syndrome (MetS), as well as postprandial hypertriglyceridemia, is associated with coronary heart disease. This study aimed to evaluate the postprandial lipemia after oral fat tolerance test (OFTT...

    Authors: Genovefa D Kolovou, Katherine K Anagnostopoulou, Antonis N Pavlidis, Klelia D Salpea, Stella A Iraklianou, Konstantinos Tsarpalis, Dimitris S Damaskos, Athanasios Manolis and Dennis V Cokkinos

    Citation: Lipids in Health and Disease 2005 4:21

    Content type: Research

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  36. Reference data for plasma lipids and blood pressure are not available for Asian Indian adolescents. This study aimed to develop representative age- and sex- specific percentile reference data for serum lipids ...

    Authors: Malini Madhavan, Ravindra M Pandey, Anoop Misra, Naval K Vikram, Vibha Dhingra, Kalpana Luthra and Jasjeet S Wasir

    Citation: Lipids in Health and Disease 2005 4:20

    Content type: Research

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  37. In order to investigate the effects of lead exposure on risk of cardiovascular disease during occupational exposure to this metal, plasma cholesterol and its fractions as high-density liporotein (HDL), low-den...

    Authors: Oladipo Ademuyiwa, Regina Ngozi Ugbaja, Florence Idumebor and Olugbenga Adebawo

    Citation: Lipids in Health and Disease 2005 4:19

    Content type: Research

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  38. Butyrylcholinesterase is an enzyme that may serve as a marker of metabolic syndrome. We (a) measured its level in persons with diabetes mellitus, (b) constructed a family tree of the enzyme using nucleotide se...

    Authors: GR Sridhar, G Nirmala, Allam Apparao, AS Madhavi, S Sreelatha, J Sudha Rani and P Vijayalakshmi

    Citation: Lipids in Health and Disease 2005 4:18

    Content type: Research

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  39. NPC1L1 encodes a putative intestinal sterol transporter which is the likely target for ezetimibe, a new type of lipid-lowering medication. We previously reported rare non-synonymous mutations in NPC1L1 in an indi...

    Authors: Robert A Hegele, Justin Guy, Matthew R Ban and Jian Wang

    Citation: Lipids in Health and Disease 2005 4:16

    Content type: Research

    Published on:

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