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  1. The excessive accumulation of body fat is a major risk factor to develop a variety of metabolic diseases. To investigate the systematic association between the differences in gene expression profiling and adip...

    Authors: Chaowei Zhou, Jie Zhang, Jideng Ma, Anan Jiang, Guoqing Tang, Miaomiao Mai, Li Zhu, Lin Bai, Mingzhou Li and Xuewei Li
    Citation: Lipids in Health and Disease 2013 12:75
    Content type: Research Published on:

  2. Elevated total plasma homocysteine (tHcy) in humans is associated with cardiovascular disease but prevention trials have failed to confirm causality. Reported reasons for this association have been that homocy...

    Authors: Elisabet Söderström, Mats Eliasson, Owe Johnson, Göran Hallmans, Lars Weinehall, Jan-Håkan Jansson and Johan Hultdin
    Citation: Lipids in Health and Disease 2013 12:74
    Content type: Research Published on:

  3. Dietary polyunsaturated fatty acids (PUFA), especially eicosapentaenoic acid (EPA), improve lipid metabolism and contribute to the prevention of vascular diseases such as atherosclerosis. However, EPA in the d...

    Authors: Tharnath Nanthirudjanar, Hidehiro Furumoto, Takashi Hirata and Tatsuya Sugawara
    Citation: Lipids in Health and Disease 2013 12:73
    Content type: Research Published on:

  4. Previous studies have reported that different genotypes of PTPN11 gene (protein tyrosine phosphatase, non-receptor 11) were associated with different levels of serum lipids. The aim of this study was to explore t...

    Authors: Zhi-Fang Jia, Xue-Yuan Cao, Dong-Hui Cao, Fei Kong, Punyaram Kharbuja and Jing Jiang
    Citation: Lipids in Health and Disease 2013 12:72
    Content type: Research Published on:

  5. Polyunsaturated fatty acids (PUFAs) have tumoricidal action, though the exact mechanism of their action is not clear. The results of the present study showed that of all the fatty acids tested, linoleic acid (...

    Authors: Jinfeng Dai, Junhui Shen, Wensheng Pan, Shengrong Shen and Undurti N Das
    Citation: Lipids in Health and Disease 2013 12:71
    Content type: Research Published on:

  6. Variants of the secreted glycoprotein, proprotein convertase subtilisin/kexin 9 (PCSK9), associate with both hypo- and hyper-cholesterolemic phenotypes. Herein, we carried out full exonic sequencing of PCSK9 docu...

    Authors: Janice Mayne, Teik Chye Ooi, Angela Raymond, Marion Cousins, Lise Bernier, Thilina Dewpura, Francine Sirois, Majambu Mbikay, Jean Davignon and Michel Chrétien
    Citation: Lipids in Health and Disease 2013 12:70
    Content type: Research Published on:

  7. Chicken meat nutritional value with regard to fatty acid composition and selenium content depends on the choice of dietary oil and selenium level used in the chickens’ feed. The objective of this study was to ...

    Authors: Nicole F Nyquist, Rune Rødbotten, Magny Thomassen and Anna Haug
    Citation: Lipids in Health and Disease 2013 12:69
    Content type: Research Published on:

  8. Alzheimer’s disease (AD), the most common cause of dementia among neurodegenerative diseases, afflicts millions of elderly people worldwide. In addition to amyloid-beta (Aβ) peptide and phosphorylated tau, lip...

    Authors: Yoko Tajima, Masaki Ishikawa, Keiko Maekawa, Mayumi Murayama, Yuya Senoo, Tomoko Nishimaki-Mogami, Hiroki Nakanishi, Kazutaka Ikeda, Makoto Arita, Ryo Taguchi, Alato Okuno, Ryuta Mikawa, Shumpei Niida, Osamu Takikawa and Yoshiro Saito
    Citation: Lipids in Health and Disease 2013 12:68
    Content type: Research Published on:

  10. In a marker-trait association study we estimated the statistical significance of 65 single nucleotide polymorphisms (SNP) in 23 candidate genes on HDL levels of two independent Caucasian populations. Each popu...

    Authors: Andrew J Clifford, Gonzalo Rincon, Janel E Owens, Juan F Medrano, Alanna J Moshfegh, David J Baer and Janet A Novotny
    Citation: Lipids in Health and Disease 2013 12:66
    Content type: Research Published on:

  11. Pure 1, 3-diacylglycerols (1, 3-DAG) have been considered to be significant surfactants in food, cosmetics and pharmaceutical industries, as well as the effect on obesity prevention.

    Authors: Nanjing Zhong, Zhongyu Gui, Li Xu, Jianrong Huang, Kun Hu, Yongqing Gao, Xia Zhang, Zhenbo Xu, Jianyu Su and Bing Li
    Citation: Lipids in Health and Disease 2013 12:65
    Content type: Research Published on:

  12. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are functionally the most important omega-3 polyunsaturated fatty acids (PUFAs). Oral supply of these fatty acids increases their levels in plasma and...

    Authors: Omer Al-Taan, James A Stephenson, Laura Spencer, Cristina Pollard, Annette L West, Philip C Calder, Matthew Metcalfe and Ashley R Dennison
    Citation: Lipids in Health and Disease 2013 12:64
    Content type: Research Published on:

  13. The gene encoding diacylglycerol acyltransferase (DGAT1) is a functional and positional candidate gene for milk and intramuscular fat content. A bovine DGAT1 overexpression vector was constructed containing mouse...

    Authors: Feifei Yang, Zhuying Wei, Xiangbin Ding, Xinfeng Liu, Xiuguo Ge, Guimin Song, Guangpeng Li and Hong Guo
    Citation: Lipids in Health and Disease 2013 12:63
    Content type: Research Published on:

  14. Inflammation is a common feature in the majority of cardiovascular disease, including Diabetes Mellitus (DM). Levels of pro-inflammatory markers have been found in increasing levels in serum from diabetic pati...

    Authors: Antonio Gordillo-Moscoso, Emilio Ruiz, Manuel Carnero, Fernando Reguillo, Enrique Rodriguez, Teresa Tejerina and Santiago Redondo
    Citation: Lipids in Health and Disease 2013 12:62
    Content type: Research Published on:

  15. Prevalence of metabolic syndrome is high and increasing in China. The causation of this disorder is, yet, to be fully understood. Several studies with confirmatory factor analysis have been performed to invest...

    Authors: Da Huo, Wei Wang, Xia Li, Qi Gao, Lijuan Wu, Yanxia Luo, Youxin Wang, Puhong Zhang and Xiuhua Guo
    Citation: Lipids in Health and Disease 2013 12:61
    Content type: Research Published on:

  16. Keloids are common cutaneous pathological scars that are characterised by the histological accumulation of fibroblasts, collagen fibres, and clinically significant invasive growth. Although increasing lines of...

    Authors: Chenyu Huang and Rei Ogawa
    Citation: Lipids in Health and Disease 2013 12:60
    Content type: Review Published on:

  17. Previously, we demonstrated that trans fatty acid ingestion during pregnancy and lactation caused a pro-inflammatory effect on the newborn. The opposite effect was described for gestational prebiotic intake. I...

    Authors: Ana Claudia Losinskas Hachul, Laís Vales Vales Mennitti, Juliana Lopes Lopes de Oliveira, Mayara Franzoi Moreno, Marcos Hiromu Okuda, Bruno dos Santos, Lila Missae Oyama, Eliane Beraldi Ribeiro, Claudia Maria Oller do Nascimento and Luciana Pellegrini Pisani
    Citation: Lipids in Health and Disease 2013 12:59
    Content type: Research Published on:

  18. Intake of high-fat diet is associated with increased non-alcoholic fatty liver disease (NAFLD). Hepatic lipid accumulation and oxidative stress are key pathophysiological mechanisms in NAFLD. Both flaxseed oil...

    Authors: Jiqu Xu, Hui Gao, Lin Song, Wei Yang, Chang Chen, Qianchun Deng, Qingde Huang, Jin’e Yang and Fenghong Huang
    Citation: Lipids in Health and Disease 2013 12:58
    Content type: Research Published on:

  19. Adults born preterm at very low birth weight (VLBW ≤ 1500g) have increased risk factors for cardiovascular diseases including high blood pressure and impaired glucose regulation. Non-optimal lipoprotein profil...

    Authors: Petteri Hovi, Eero Kajantie, Pasi Soininen, Antti J Kangas, Anna-Liisa Järvenpää, Sture Andersson, Johan G Eriksson, Mika Ala-Korpela and Karoliina Wehkalampi
    Citation: Lipids in Health and Disease 2013 12:57
    Content type: Short report Published on:

  20. Growth hormone (GH) and insulin signaling pathways are known important regulators of adipose homeostasis. The cross-talk between GH and insulin signaling pathways in mature adipocytes is poorly understood.

    Authors: Yuchao Zhang, Yuantao Liu, Xia Li, Weina Gao, Wenjie Zhang, Qingbo Guan, Jing Jiang, Stuart J Frank and Xiangdong Wang
    Citation: Lipids in Health and Disease 2013 12:56
    Content type: Research Published on:

  21. Women often lag behind men in their risk of cardiovascular events. However, with age and the onset of menopause, women’s cardiovascular risk eventually becomes similar to that of men. This change in risk may, ...

    Authors: Heidi T May, John R Nelson, Krishnaji R Kulkarni, Jeffrey L Anderson, Benjamin D Horne, Tami L Bair and Joseph B Muhlestein
    Citation: Lipids in Health and Disease 2013 12:55
    Content type: Research Published on:

  22. Insulin treatment can lead to good glycemic control and result in improvement of lipid parameters in type 2 diabetic patients. This study was designed to evaluate the effect of insulin analog initiation therap...

    Authors: Ibrahim Aslan, Ertan Kucuksayan and Mutay Aslan
    Citation: Lipids in Health and Disease 2013 12:54
    Content type: Research Published on:

  23. There is little knowledge about the effect of dyslipidaemia on the outcome after lung transplantation. Thus, the aim of this retrospective single centre study was to analyse the impact of the plasma lipid prof...

    Authors: Urs Wenger, Silvia R Cottini, Georg Noll, Stefan Arndt, Paul A Stehberger, Stefanie Klinzing, Reto A Schuepbach and Markus Béchir
    Citation: Lipids in Health and Disease 2013 12:53
    Content type: Short report Published on:

  24. The use of bioactive antioxidants in feed of broiler to mitigate reactive oxygen species (ROS) in biological systems is one of promising nutritional strategies. The aim of present study was to alleviate ROS pr...

    Authors: Rashida Parveen, Ali Asghar, Faqir M Anjum, Muhammad I Khan, Muhammad Sajid Arshad and Ammara Yasmeen
    Citation: Lipids in Health and Disease 2013 12:52
    Content type: Research Published on:

  25. During the past 100 years, several theories explaining human atherosclerosis have been postulated and tested. More than anything else, experimental and observational evidence has supported a very strong causal...

    Authors: Pauli Ohukainen
    Citation: Lipids in Health and Disease 2013 12:51
    Content type: Commentary Published on:

  26. HIV and combination antiretroviral therapy (cART) may increase cardiovascular disease (CVD) risk. We assessed the early effects of cART on CVD risk markers in a population with presumed low CVD risk.

    Authors: James N Kiage, Douglas C Heimburger, Christopher K Nyirenda, Melissa F Wellons, Shashwatee Bagchi, Benjamin H Chi, John R Koethe, Donna K Arnett and Edmond K Kabagambe
    Citation: Lipids in Health and Disease 2013 12:50
    Content type: Research Published on:

  27. Dyslipidemia and activation of renin-angiotensin system (RAS) contribute to the progression of chronic kidney disease (CKD). This study investigated possible synergistic effects of intrarenal RAS activation wi...

    Authors: Jie Ni, Kun-Ling Ma, Chang-Xian Wang, Jing Liu, Yang Zhang, Lin-Li Lv, Hai-Feng Ni, Ya-Xi Chen, Xiong-Zhong Ruan and Bi-Cheng Liu
    Citation: Lipids in Health and Disease 2013 12:49
    Content type: Research Published on:

  28. A PPARγ fluorescence polarization (FP) assay was used to measure the release of fatty acid products from triglyceride emulsions during digestion with pancreatic and yeast lipases in a real-time, homogenous ass...

    Authors: Harry Martin, Tony K McGhie, Kerry Bentley-Hewitt and John Christeller
    Citation: Lipids in Health and Disease 2013 12:48
    Content type: Research Published on:

  29. We assessed the influence of atorvastatin on selected indicators of an inflammatory condition, left ventricular function, hospitalizations and mortality in patients with dilated cardiomyopathy (DCM).

    Authors: Agata Bielecka-Dabrowa, Dimitri P Mikhailidis, Manfredi Rizzo, Stephan von Haehling, Jacek Rysz and Maciej Banach
    Citation: Lipids in Health and Disease 2013 12:47
    Content type: Research Published on:

  30. Delayed wound healing is considered one of the most serious diabetes-associated complications. The presence of replicating organisms such as bacteria within a diabetic’s wound is considered one of the most imp...

    Authors: Gamal Badr
    Citation: Lipids in Health and Disease 2013 12:46
    Content type: Research Published on:

  31. Preparation of some novel heterocyclic compounds with long alkyl and alkenyl chain of cytotoxic activity.

    Authors: Selvaraj Jubie, Palanisamy Dhanabal, Mohammed Afzal Azam, Nithyanantham Muruganantham, Rajagopal Kalirajan and Kannan Elango
    Citation: Lipids in Health and Disease 2013 12:45
    Content type: Research Published on:

  33. Apolipoprotein-E (apoE) is one of the metabolically active apoproteins and plays an important role in lipid metabolism. However, there are no data on levels of apoE in residents of the North in spite of the fa...

    Authors: Anastasiya M Kaneva, Evgeny R Bojko, Natalya N Potolitsyna and Jon O Odland
    Citation: Lipids in Health and Disease 2013 12:43
    Content type: Research Published on:

  34. The aim of this study was to investigate the effect of C-reactive protein/oxidised low-density lipoprotein/β2-glycoprotein I (CRP/oxLDL/β2GPI) complex on atherosclerosis (AS) in diabetic BALB/c mice.

    Authors: Rui Zhang, Sai-Jun Zhou, Chun-Jun Li, Xiao-Nan Wang, Yun-Zhao Tang, Rui Chen, Lin Lv, Qian Zhao, Qiu-Ling Xing, De-Min Yu and Pei Yu
    Citation: Lipids in Health and Disease 2013 12:42
    Content type: Research Published on:

  35. Genetic factors implicated in the pathogenesis of non-alcoholic fatty liver disease are poorly understood. Our aim was to characterize three genes involved in a rat model of non-alcoholic fatty liver disease a...

    Authors: Hemda Schmilovitz-Weiss, Edith Hochhauser, Michal Cohen, Yelena Chepurko, Smadar Yitzhaki, Ehud Grossman, Avshalom Leibowitz, Zvi Ackerman and Ziv Ben-Ari
    Citation: Lipids in Health and Disease 2013 12:41
    Content type: Research Published on:

  37. The development of osteoporosis is associated with several risk factors, such as genetic polymorphisms and enviromental factors. This study assessed the correlation between SAA1 gene rs12218 polymorphism and H...

    Authors: Zheng-Ping Feng, Xiao-Yu Li, Rong Jiang, Hua-Cong Deng, Mei Yang, Qin Zhou, Wen-Jun Que and Jia Du
    Citation: Lipids in Health and Disease 2013 12:39
    Content type: Research Published on:

  38. In an effort to identify new alternatives for long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) supplementation, the effect of three sources of omega 3 fatty acids (algae, fish and Echium oils) on lipid pr...

    Authors: Patrícia Borges Botelho, Karina da Rocha Mariano, Marcelo Macedo Rogero and Inar Alves de Castro
    Citation: Lipids in Health and Disease 2013 12:38
    Content type: Research Published on:

  39. Epidemiological studies have shown that the offspring of mothers who experience diabetes mellitus during pregnancy are seven times more likely to develop health complications than the offspring of mothers who ...

    Authors: Gamal Badr, Mohamed H Mahmoud, Karim Farhat, Hanan Waly, Osman Zin Al-Abdin and Danny M Rabah
    Citation: Lipids in Health and Disease 2013 12:37
    Content type: Research Published on:

  40. B-Cell chronic lymphocytic leukemia (CLL) is the most common form of leukemia in the United States. Clinical treatment of CLL is often limited due to drug resistance and severe therapy-induced toxicities. We h...

    Authors: Johannes F Fahrmann and W Elaine Hardman
    Citation: Lipids in Health and Disease 2013 12:36
    Content type: Research Published on:

  41. Maize-based food is typical in Mexico and other Mesoamerican countries. Used for millennia, they have recently been replaced by modern food that is associated with an increase in the prevalence of non-communic...

    Authors: Juan Manuel Muñoz Cano, Andrea Carrillo Aguilar and Juan Córdova Hernández
    Citation: Lipids in Health and Disease 2013 12:35
    Content type: Research Published on:

  42. Betaine is a methyl donor and has been considered as a lipotropic effect substance. But its mechanism remains unclear. Hepatic steatosis is associated with abnormal expression of genes involved in hepatic lipi...

    Authors: Lijun Wang, Li Chen, Yaozong Tan, Jun Wei, Ying Chang, Tianru Jin and Huilian Zhu
    Citation: Lipids in Health and Disease 2013 12:34
    Content type: Research Published on:

  43. Beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on the reproduction of male animals are widely described in the literature. However, there is little information about the effect of n-3/n-...

    Authors: Lin Yan, Xiao-long Bai, Zheng-feng Fang, Lian-qiang Che, Sheng-yu Xu and De Wu
    Citation: Lipids in Health and Disease 2013 12:33
    Content type: Research Published on:

  44. MicroRNAs (miRNAs) emerge as new important regulators of lipid homeostasis by regulating corresponding genes. MiR-613 is a newly discovered microRNA, of which the biological function is unknown. A recent repor...

    Authors: Dan Zhong, Yan Zhang, Yi-jun Zeng, Min Gao, Geng-ze Wu, Chang-jiang Hu, Gang Huang and Feng-tian He
    Citation: Lipids in Health and Disease 2013 12:32
    Content type: Research Published on:

  45. The aim of the present prospective study was to examine whether lipoprotein (a) [Lp(a)] phenotypes and/or low relative lymphocyte concentration (LRLC) are independently associated with coronary heart disease (...

    Authors: Tatsuya Suzuki, Shoko Futami-Suda, Yoshimasa Igari, Kentaro Watanabe, Motoshi Ouchi, Kazunari Suzuki, Ken-ichi Sekimizu, Yoshiaki Kigawa, Hiroshi Nakano and Kenzo Oba
    Citation: Lipids in Health and Disease 2013 12:31
    Content type: Research Published on:

  46. Exposure to the pyrethroid pesticide deltamethrin has been demonstrated to exert a wide range of effects on non-targeted organisms. The beneficial effects of geranuim essential oil (EO) as an antioxidant has b...

    Authors: Ahlem Ben Slima, Manel Ben Ali, Mohamed Barkallah, Al Ibrahim Traore, Tahia Boudawara, Noureddine Allouche and Radhouane Gdoura
    Citation: Lipids in Health and Disease 2013 12:30
    Content type: Research Published on:

  47. Intake of high-fat diet is associated with increased fatty livers. Hepatic lipid accumulation and oxidative stress are key pathophysiological mechanisms in this disease. Micronutrients polyphenols, tocopherols...

    Authors: Jiqu Xu, Xiaoqi Zhou, Hui Gao, Chang Chen, Qianchun Deng, Qingde Huang, Jing Ma, Zhengyang Wan, Jin’e Yang and Fenghong Huang
    Citation: Lipids in Health and Disease 2013 12:28
    Content type: Research Published on:

  48. Docosahexaenoic acid (DHA) is a long-chain omega-3 polyunsaturated fatty acid (LCPUFA) that is critically important for the structure, development and function of the retina and central nervous system (CNS), u...

    Authors: Hsiao-Ling Huang, Lu-Te Chuang, Hsi-Hsin Li, Chiu-Ping Lin and Robert H Glew
    Citation: Lipids in Health and Disease 2013 12:27
    Content type: Research Published on:

  49. Our previous work showed that dietary oxidized linoleic acid given, as a single fatty acid, to LDL receptor knockout mice decreased weight gain as compared to control mice. Other studies have also reported tha...

    Authors: Meera Penumetcha, Mary K Schneider, Holly A Cheek and Sonia Karabina
    Citation: Lipids in Health and Disease 2013 12:26
    Content type: Short report Published on:

  50. Lipid desaturase enzymes mediate the metabolism of fatty acids to long chain polyunsaturated fatty acids and their activities are related to metabolic risk factors for Type 2 diabetes (T2DM) and coronary heart...

    Authors: Robert G Gray, Eleni Kousta, Mark I McCarthy, Ian F Godsland, Soundarajan Venkatesan, Victor Anyaoku and Desmond G Johnston
    Citation: Lipids in Health and Disease 2013 12:25
    Content type: Research Published on:
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Lipids in Health and Disease

ISSN: 1476-511X