Table 1 Kinetic Constants of the AEA Membrane Transporter (AMT) in Brain Synaptosomes and Inhibition by Glutamine and Glutamate

Kinetic constant	Human Meningioma	Mouse Brain	Rat Brain
K_m (nM)	793 ± 128	660 ± 80	483 ± 52
V_max (pmol/min per mg protein)	219 ± 19	370 ± 23	357 ± 18
K_i of L-Glutamine (nM)^a	1100 ± 90	970 ± 80	850 ± 80
K_i of D-Glutamine (nM)^a	525 ± 50	480 ± 50	430 ± 45
K_i of L-Glutamate (nM)^a	4000 ± 370	3580 ± 300	3300 ± 310
K_i of D-Glutamate (nM)^a	1230 ± 110	1100 ± 90	850 ± 80

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