Lipids in Health and Disease

Table 1 Clinical parameters of donors and recipients at baseline, 6 weeks and 6 months after living-donor kidney transplantation (LDKT)^#

From: Vitamin A metabolism is changed in donors after living-kidney transplantation: an observational study

	Donors			Recipients
N (m/f)	20 (6/14)			20 (14/6)
Age (a)	46 (27-66)			42 (6-77)
	Baseline	6 weeks after LDKT	6 months after LDKT	Baseline	6 weeks after LDKT	6 months after LDKT
eGFR (mL/min per 1.73 m²)	84 (68-139)^a***	58 (40-94)^b	57 (40-88)^b	8 (5-16)^A	61 (24-145)^B	63 (19-172)^B
Proteinuria (mg/L)	47 (40-260) ***	40 (40-92) *	44 (40-105) *	544 (42-1943)	175 (37-762)	73 (45-1238)
UP/UC	0.09 (0.04-0.84) ***	0.10 (0.04-0.27)	0.09 (0.04-0.17)	0.78 (0.05-4.43)^A	0.13 (0.06-0.37)^B	0.10 (0.03-1.44)^B
CRP (mg/dL)	0.17 (0.04-2.13)	0.34 (0.03-1.21)	0.28 (0.04-2.72)	0.21 (0.02-1.45)	0.26 (0.02-3.91)	0.22 (0.02-2.57)
Total cholesterol (mg/dL)	182 (141-279)	177 (142-289)	193 (118-269)	182 (126-353)^A	193 (90-291)^AB	191 (134-312)^B
LDL cholesterol (mg/dL)	116 (67-214)	115 (72-211)	126 (68-188)	120 (76-240)	131 (72-222)	126 (72-204)
HDL cholesterol (mg/dL)	58 (39-94) **	53 (36-90)	56 (35-92)	46 (29-71)^A	52 (36-119)^B	50 (30-78)^B
Trigylcerides (mg/dL)	94 (46-298) ***	124 (64-292) **	116 (72-397) *	230 (81-671)	207 (81-443)	179 (81-545)
ROH (μg/mL)	0.61 (0.37-0.84)^a***	0.81 (0.41-1.07)^b	0.67 (0.43-1.09)^b	1.46 (0.67-2.25)^A	0.88 (0.38-1.79)^B	1.01 (0.32-1.44)^B
RBP4 (μmol/L)	1.76 (1.08-2.13)^a***	2.11 (1.02-3.38)^b	2.55 (1.19-3.89)^c	6.57 (3.19-8.77)^A	2.80 (1.10-6.38)^B	3.06 (0.99-5.23)^B
TTR (μmol/L)	2.58 (0.96-5.78) ***	3.25 (0.47-5.06)	3.08 (1.91-4.99)	5.60 (2.06-8.37)^A	3.51 (1.58-8.24)^B	4.53 (1.05-6.38)^B
apoRBP4 (%)	0.0 (0.0-8.2)^a***	8.3 (0.6-13.1)^b	7.6 (0.3-9.6)^b	30.7 (1.2-47.6)^A	12.9 (0.8-23.4)^B	10.2 (0.6-31.0)^B

^# Data are presented as median (range). Abbreviations used: CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; HDL, high density lipoprotein; LDL, low density lipoprotein; LDKT, living-donor kidney transplantation; m/f; male/female; UP/UC, urine protein/urine creatinine ratio. Different superscripts ^{a, b} and ^c indicate significant differences between the different time points for donors. Different superscripts ^A and ^B indicate significant differences between the different time points for recipients. Superscripts *, ** and *** indicate significant differences between donors and recipients at the particular time point with * p < 0.05, ** p < 0.01 and *** p < 0.001.

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