Tocotrienols-induced inhibition of platelet thrombus formation and platelet aggregation in stenosed canine coronary arteries

Table 3 Effects of α-tocotrienol on the concentration of tocols in canine plasma and platelets¹

Treatments	Total tocopherols (T)²	Total tocotrienols (T3)³	Total T + T3
α-Tocotrienol (T3)		Concentrations in μg/ml (ppm)
Plasma (Pre-dose)
Total Tocols⁴	10.10 ± 0.82 ^a (92) ⁵	0.90 ± 0.03 ^a (8)	11.02 ± 0.81 ^a (100)
Plasma (Post-dose)
Total Tocols	45.11 ± 2.19 ^b (94)	2.78 ± 0.13 ^b (6)	47.89 ± 2.17 ^b (100)
Platelets (Pre-dose)
Total Tocols	5.12 ± 1.24 ^a (83)	1.02 ± 0.03 ^a (7)	6.14 ± 1.22 ^a (100)
Platelets (Post-dose)
Total Tocols	28.16 ± 1.54 ^b (96)	1.28 ± 0.04 ^a (4)	29.44 ± 1.52 ^b (100)

¹Data expressed as means ± SD, n = 3, 3, and 4 respectively, per treatment.
²Total tocopherols = Mixture of α-tocopherol + β-tocopherol + γ-tocopherol + δ-tocopherol (T).
³Total tocotrienols = Mixture of α-tocotrienol + β-tocotrienol + γ-tocotrienol + δ-tocotrienol (T3).
⁴Tocols = Mixture of α-, β-, γ-, and δ-tocopherols (T) + α-, β-, γ-, and δ-tocotrienols (T3).
⁵Percentages of control values are in parentheses.
^a-bValues in columns with a different superscript letter are significantly different at P < 0.05.

ISSN: 1476-511X