Index Cases N = 387 | FHR (+) N = 875 | FHR (-) N = 590 | P-value | |
---|---|---|---|---|
Gender (male)% | 52.2 | 46.3 | 46.3 | 0.117 |
Mean age (years) * (Age range) | 49.1 ± 12.9 (20.2-78.0) | 44.1 ± 15.2 (20.1-79.0) | 41.3 ± 14.7 (20.2-78.5) | < 0.001 |
Previous Clinical Diagnosis of FH (%) | 100 | 74.6 | 13.9 | < 0.001 |
History of CVD (%) | 21.7 | 10.6 | 3.2 | < 0.001 |
Age of first Cardiovascular event (Age range) | 42.8 ± 9.7 (24.0-67.0) | 50.3 ± 11.6 (28.0-76.0) | 53.9 ± 8.5 (39.0-69.0) | < 0.001 |
Previous LLT (%) | 96.9 | 77.8 | 18.8 | < 0.001 |
Type 2 Diabetes (%) | 2.1 | 4.0 | 3.6 | 0.220 |
High Blood Pressure (%) | 14.7 | 14.6 | 12.7 | 0.531 |
Tobacco (current/past)(%) | 20.2/33.3 | 32.0/21.0 | 34.6/17.1 | < 0.001 |
Xanthomas (%) | 20.7 | 12.8 | 0.0 | < 0.001 |
BMI (Kg/m2) * | 26.7 ± 4.3 | 26.6 ± 5.00 | 26.2 ± 5.2 | 0.272 |
Total cholesterol (mg/dL)* | 256.6 ± 71.9 | 264.6 ± 69.6 | 213.3 ± 46.4 | < 0.001 |
Triglycerides (mg/dL)** | 89.0 (52) | 85.0 (56) | 85.0 (54) | 0.239 |
LDL-C (mg/dL)* | 188.0 ± 69.9 | 193.8 ± 66.9 | 131.3 ± 41.4 | < 0.001 |
HDL-C (mg/dL)* | 48.6 ± 13.6 | 50.3 ± 13.9 | 51.1 ± 13.9 | 0.001 |