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Table 2 Thiobarbituric acid-reactive substances (TBARS) and lactate dehydrogenase (LDH) activity in brain, liver and plasma of different experimental groups.

From: Study of lipid profile and parieto-temporal lipid peroxidation in AlCl3 mediated neurotoxicity. modulatory effect of fenugreek seeds

Parameter

Experimental groups

 

Control

AlCl3

AlCl3+FSP

AlCl3+FSE

FSP

FSE

Brain

      

TBARS

3.43 ± 0.35

6.12a* ± 0.12

3.76b* ± 0.21

2.46b* ± 0.28

4.07 ± 0.02

4.15 ± 0.37

LDH

84.9 ± 1.27

115.8a ± 7.21

86.4b ± 3.65

93.3a*b ± 0.20

83.05 ± 1.58

83.13 ± 2.64

Liver

      

TBARS

2.15 ± 0.18

3.11a ± 0.24

2.75 ± 0.20

2.32b ± 0.15

3.02a ± 0.07

2.88a ± 0.25

LDH

191.4 ± 6.45

282.2a* ± 11.2

199.9b*c* ± 0.80

185.5b*c* ± 2.62

195.7 ± 3.49

184.9 ± 0.30

Plasma

      

TBARS

0.82 ± 0.03

1.21a ± 0.09

0.79b ± 0.02

0.91b ± 0.02

0.88 ± 0.01

1.05a* ± 0.02

LDH

485.5 ± 14.0

1071.5a* ± 5.59

891.5a*b* ± 20.3

914.0a*b* ± 0.01

575.5 ± 120.0

463.0 ± 30.8

  1. Values are expressed as means ± SD; n = 10 for each treatment group.
  2. a Significant difference from the control group at p < 0.05.
  3. b Significant difference from the AlCl3-intoxicated group at p < 0.05.
  4. c Significant difference between AlCl3+FSP and AlCl3+FSE groups at p < 0.05.
  5. * p < 0.001.
  6. In brain and liver TBARS and LDH are expressed respectively as: nmol MDA/mg protein and UI/g of tissue; in plasma TBARS and LDH are expressed respectively as: nmol MDA/l and UI/l.