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Table 2 Plasma concentration of total aminothiols (glutathione, homocysteine, cysteine and cysteinylglycine) at baseline and after the 28-day treatment with fenofibrate or placebo

From: Treatment of chronic hemodialysis patients with low-dose fenofibrate effectively reduces plasma lipids and affects plasma redox status

Parameter

Healthy controls*

Baseline

After Placebo

After Fenofibrate

Glutathione [nmol/mL]

11.9 ± 4.9

5.6 ± 1.4

5.6 ± 1.6

6.5 ± 1.7#

Homocysteine [nmol/mL]

11.3 ± 3.2

24.2 ± 12.0

26.9 ± 13.1

29.4 ± 20.2##

Cysteine [nmol/mL]

275 ± 99

535 ± 105

552 ± 107

542 ± 106

Cysteinylglycine [nmol/ml]

25 ± 7

58 ± 12

56 ± 10

56 ± 14

  1. * healthy controls – historic cohort from Bald E et al. [19]
  2. # p = 0.02 vs baseline; ## p = 0.04 vs baseline
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Lipids in Health and Disease

ISSN: 1476-511X