Association between APOE, SCARB1, PPARα polymorphisms and serum lipids in a population of Lithuanian adults

Table 4 Odds ratios for the likelihood of dyslipidemias according to the APOE , SCARB1, PPARα genotypes in the study population

The genotypes	High TC	High LDL-C	Reduced HDL-C	Elevated TG
The genotypes	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)
		MEN
*APOE*
APOE3	1	1	1	1
APOE2	0.60 (0.33-1.02)	0.60 (0.35-1.02)	1.56 (0.85-2.85)	1.36 (0.79-2.34)
APOE4	1.04 (0.58-1.88)	1.37 (0.74-2.54)	1.98 (1.05-3.74)	1.50 (0.84-2.67)
*SCARB 1*
CC	1	1	1	1
CT	1.20 (0.77-1.84)	1.09 (0.69-1.72)	0.76 (0.45-1.26)	0.50 (0.31-0.79)
TT	1.67 (0.89-3.23)	1.91 (0.98-3.73)	0.75 (0.36-1.58)	0.66 (0.35-1.26)
*PPARα*
CC	1	1	1	1
CG	1.12 (0.47-2.66)	0.79 (0.34-1.84)	0.52 (0.15-1.84)	2.67 (1.15-6.16)
		WOMEN
*APOE*
APOE3	1	1	1	1
APOE2	0.52 (0.32-0.83)	0.35 (0.22-0.57)	0.62 (0.34-1.11)	0.97 (0.57-1.66)
APOE4	0.84 (0.54-1.30)	0.96 (0.62-1.49)	0.78 (0.48-1.29)	1.10 (0.69-1.76)
*SCARB 1*
CC	1	1	1	1
CT	1.18 (0.80-1.74)	1.14 (0.78-1.68)	1.43 (0.92-2.23)	1.16 (0.76-1.77)
TT	1.39 (0.83-2.33)	0.83 (0.50-1.37)	0.82 (0.43-1.53)	1.03 (0.58-1.80)
*PPARα*
CC	1	1	1	1
CG	1.71 (0.77-3.80)	1.95 (0.86-4.43)	1.23 (0.54-2.84)	0.82 (0.34-1.96)

Data adjusted by age, body mass index, physical activity, and alcohol consumption.
APOE2 - carriers of the ϵ 2/2 and ϵ 2/3 genotype, APOE3 - carriers of the ϵ 3/3 genotype, and APOE4 - carriers of the ϵ 3/4 and ϵ 4/4 genotype.
Abrevations: APOE apolipoprotein E, Elevated TG triglycerides level >1.7 mmol/L, High TC total cholesterol ≥5.0 mmol/L, High LDL-C low density lipoprotein cholesterol ≥3.0 mmol/L, PPARα Peroxisome proliferator-activated receptor-alpha, Reduced HDL- C high density lipoprotein cholesterol level for men<1.0 mmol/L and for women <1.20 mmol/L, SCARB 1 Scavenger Receptor Class B Type 1.

ISSN: 1476-511X