Figure 5
Cessation of dietary supplementation reverses inhibition of FcϵRI-dependent cysteinyl leukotriene generation by peripheral blood basophils. After 3 weeks of dietary supplementation (open bars), subjects stopped ingesting borage and echium seed oils. FcϵRI-stimulated basophilic cysteinyl leukotriene generation was measured at one (gray bar), two (cross-hatched bar) and three weeks (solid bar) of washout. Data are shown for maximal cysteinyl leukotriene generation in response to 1.0 μg/ml 15A5. Data are expressed as a percentage of maximal cysteinyl leukotriene generation in each subject and are expressed as means ± SEM.