Skip to main content
Figure 4 | Lipids in Health and Disease

Figure 4

From: A fish protein hydrolysate alters fatty acid composition in liver and adipose tissue and increases plasma carnitine levels in a mouse model of chronic inflammation

Figure 4

The effect of fish protein hydrolysate on hepatic genes involved in fatty acid metabolism. hTNFα transgenic mice were given a 15% (w/w) fish protein hydrolysate (FPH) diet for two weeks, fasted over night, and the hepatic expression of selected genes was analyzed. β-oxidation: carnitine palmitoyl transferase 1 (Cpt1a) (a), carnitine palmitoyl transferase 2 (Cpt2) (b), acyl-CoA oxidase 1 (Acox1) (c), trifunctional enzyme (Hadha) (d). Ketogenesis: HMG-CoA synthase 2 (Hmgcs2) (e). Triacylglycerol lipase activity: arylacetamide deacetylase (Aadac) (f). Lipogenesis: acyl-coA carboxylase (Acaca) (g), (steroyl-CoA desaturase 1 (Scd1) (h). An indirect index of hepatic and white adipose tissue (WAT) SCD1 activity was calculated as C18:1n-9/C18:0 (i). Data are given as means ± SD (n = 5), and values significantly different from control are indicated (*P < 0.05, **P < 0.01, ***P < 0.001).

Back to article page

Lipids in Health and Disease

ISSN: 1476-511X