| Lean | Obese | Main effects |  | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
 | CON | FLAX | FISH | SDA | CON | FLAX | FISH | SDA | Genotype | Diet | Interaction |
Total EI ( kcal ) | 7588 ± 231 | 7381 ± 230 | 7296 ± 228 | 7276 ± 235 | 9208 ± 249 | 9595 ± 219 | 9069 ± 238 | 8824 ± 264 | P < 0.0001‡ | P = 0.09 | P = 0.30 |
Body weight ( g ) | 497.9 ± 15.7 | 481.3 ± 15.6 | 487.8 ± 15.4 | 485.7 ± 15.9 | 635.6 ± 16.8 | 647.7 ± 14.9 | 626.7 ± 16.1 | 611.0 ± 17.9 | P < 0.0001‡ | P = 0.47 | P = 0.43 |
Body fat mass (%) | 15.35 ± 0.98 | 15.24 ± 0.97 | 15.53 ± 0.96 | 13.53 ± 0.99 | 47.79 ± 1.05 | 49.86 ± 0.93 | 48.23 ± 1.01 | 45.84 ± 1.12 | P < 0.0001‡ | P = 0.0038i | P = 0.22 |
Body lean mass ( % ) | 68.27 ± 0.85 | 68.58 ± 0.84 | 68.09 ± 0.84 | 69.68 ± 0.86 | 40.31 ± 0.91 | 38.87 ± 0.81 | 39.75 ± 0.87 | 41.31 ± 0.97 | P < 0.0001†| P = 0.050ii | P = 0.61 |
Adj. liver weight ( % ) | 2.60 ± 0.16 | 2.67 ± 0.16 | 2.88 ± 0.16 | 2.79 ± 0.16 | 3.67 ± 0.17 | 3.75 ± 0.15 | 3.49 ± 0.16 | 3.41 ± 0.18 | P < 0.0001‡ | P = 0.81 | P = 0.17 |
Liver fat mass ( % ) | 9.15 ± 1.36a | 8.01 ± 1.35a | 10.30 ± 1.34a | 9.22 ± 1.39a | 20.52 ± 1.45cd | 21.72 ± 1.28d | 15.97 ± 1.38b | 18.60 ± 1.48bc | P < 0.0001‡ | P = 0.37 | ΔP = 0.0053 |
Liver lean mass (%) | 87.47 ± 1.73c | 85.41 ± 1.72c | 86.10 ± 1.70c | 84.04 ± 1.76c | 73.05 ± 1.44a | 72.94 ± 1.62a | 78.46 ± 1.35b | 76.56 ± 1.48b | P < 0.0001†| P = 0.19 | ΔP = 0.039 |
Glucose (AUC) | 2580 ± 173 | 2364 ± 171 | 2618 ± 170 | 2540 ± 176 | 2740 ± 184 | 2544 ± 174 | 3055 ± 176 | 3074 ± 189 | P = 0.017 | P = 0.35 | P = 0.46 |
Glucose to insulin ratio | 17.69 ± 3.40 | 23.54 ± 3.32 | 17.37 ± 3.28 | 18.46 ± 3.42 | 1.15 ± 3.50 | 4.32 ± 3.31 | 1.21 ± 3.34 | 1.45 ± 3.59 | P = 0.0003‡ | P = 0.28 | P = 0.77 |
Insulin ( pmol/L ) | 0.90 ± 1.10 | 0.83 ± 1.07 | 2.32 ± 1.06 | 1.00 ± 1.10 | 5.92 ± 1.16 | 4.09 ± 1.07 | 6.19 ± 1.08 | 5.57 ± 1.16 | P = 0.0057‡ | P = 0.25 | P = 0.94 |