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Table 1 Baseline characteristics by lipoprotein (a) [Lp(a)] phenotype

From: Low-molecular-weight lipoprotein (a) and low relative lymphocyte concentration are significant and independent risk factors for coronary heart disease in patients with type 2 diabetes mellitus: Lp(a) phenotype, lymphocyte, and coronary heart disease

Baseline characteristics

All subjects (n = 214)

HMW Lp(a) (no. of KIV2 repeats: > 22) group (n = 169)

LMW Lp(a) (no. of KIV 2 repeats: 11–22) group (n = 45)

P-value

Age (years)

62 ± 10

61 ± 10

65 ± 10

0.068

Gender (male/female)

105/99

93/76

22/23

0.489

White blood cells (/mm3)

6,197 ± 1563

6,134 ± 1609

6,447 ± 1362

0.250

  Neutrophil (/mm3)

3,711 ± 1223

3,677 ± 1262

3,838 ± 1057

0.433

  Monocyte (/mm3)

348 ± 142

360 ± 139

399 ± 152

0.101

  Basophil (/mm3)

37 ± 46

40 ± 62

34 ± 30

0.527

  Eosinophil (/mm3)

173 ± 132

170 ± 126

185 ± 154

0.511

  Lymphocyte (/mm3)

1,889 ± 617

1,866 ± 601

1,973 ± 675

0.305

  Neutrophil (%)

59.5

59.5

59.0

0.901

  Monocyte (%)

6.0

5.9

6.3

0.353

  Basophil (%)

0.6

0.6

0.5

0.302

  Eosinophil (%)

2.9

2.9

2.0

0.813

  Lymphocyte (%)

31.0

31.0

30.8

0.884

Systolic blood pressure (mmHg)

138 ± 16

138 ± 17

138 ± 15

0.960

Diastolic blood pressure (mmHg)

81 ± 10

81 ± 10

80 ± 10

0.676

Lp(a) (mg/dL)

24.1 ± 26.8

16.2 ± 13.4

53.5 ± 40.9

< 0.001

(median: range)

(14.6: 0–221.0)

(13.0: 0–73.3)

(41.5: 8–221.0)

 

Total cholesterol (mg/dL)

211 ± 39

211 ± 40

213 ± 35

0.781

HDL-C (mg/dL)

60 ± 19

61 ± 20

58 ± 17

0.492

Triglyceride (mg/dL)

134 ± 92

134 ± 93

131 ± 92

0.790

LDL-C (mg/dL)

125 ± 31

123 ± 32

129 ± 29

0.270

Creatinine (mg/dL)

1.0 ± 0.4

1.0 ± 0.4

0.9 ± 0.2

0.348

Fasting plasma glucose (mg/dL)

166 ± 65

168 ± 66

162 ± 62

0.503

HbA1c (%)

7.9 ± 1.8

8.0 ± 1.8

7.6 ± 1.6

0.222

Body mass index (kg/m2)

23.3 ± 4.1

23.3 ± 4.2

23.6 ± 4.0

0.665

Statins/fibrates (%)

38.8

34.1

57.8

0.004

ACE-I/ARBs (%)

22.0

18.3

35.6

0.031

CCBs (%)

27.6

26.5

33.3

0.364

Antiplatelets (%)

24.3

24.5

23.3

0.862

Peripheral vascular disease

5.1

5.3

4.4

0.819

Stroke (%)

9.8

11.2

4.4

0.091

CKD II/III (%)

93.5

92.9

95.6

0.524

Current smoker (%)

27.5

26.0

32.5

0.412

C-reactive protein (%)§

86.9

88.1

75.0

0.342

  1. Values are expressed as mean ± SD or numeral (%).
  2. HMW, high-molecular-weight; LMW, low-molecular-weight; §: Proportion of subjects with a C-reactive protein value of < 4.0 mg/L; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; HbA1c, glycated hemoglobin; ACE-I/ARBs, angiotensin- converting enzyme inhibitors/angiotensin receptor blockers; CCBs, calcium channel blockers; CKD, chronic kidney disease.
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Lipids in Health and Disease

ISSN: 1476-511X