Serological responses to prednisolone treatment in leprosy reactions: study of TNF-α, antibodies to phenolic glycolipid-1, lipoarabinomanan, ceramide and S100-B

Table 2 Serological markers and their association with nerve pain, tenderness and NFI

S. no	No of serological markers	% increase in serological markers before reaction (n = 72)	% decrease in serological markers after reaction (n = 72)	During the reaction percentage increase
				Nerve pain	Nerve tenderness	New Nerve Function Impairment (NFI)
1.	One	7	4.2	20	0	80
2.	Two	15.3	14	36.4	9	72.7
3.	Three	31	25	31.8	27.2	54.5
4.	Four	22.2	26.4	62.5	31.2	43.7
5.	Five	14	21	20	20	60
6.	Six	6	7	25	25	25
7.	Seven	1.4	3	0	0	100

Any of the serological markers TNF-α, antibodies to Ceramide; S100; PGL-1 IgG; PGL-1 IgM; LAM IgG1 and LAM IgG3 increased one month before the reaction and decreased a month after the reaction and their association with clinical symptoms of nerve pain, nerve tenderness and new nerve function impairment.

ISSN: 1476-511X