Table 2 Genotype and allele distributions in patients with CAD and control subjects (Han population)
Total | Men | Women | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
CAD n (%) | Control n (%) | P value | CAD n (%) | Control n (%) | P value | CAD n (%) | Control n (%) | P value | ||||
rs731119 (SNP1) | Genotype | G/G | 369 (60.8) | 375 (64.1) | 0.236 | 237 (61.2) | 227 (63.9) | 0.695 | 132 (60) | 148 (64.3) | 0.283 | |
A/A | 21 (3.5) | 26 (4.4) | 11 (2.8) | 11 (3.1) | 10 (4.5) | 15 (6.5) | ||||||
A/G | 217 (35.7) | 184 (31.5) | 139 (35.9) | 117 (33) | 78 (35.5) | 67 (29.1) | ||||||
Dominant model | GG | 369 (60.8) | 375 (64.1) | 0.238 | 237 (61.2) | 227 (63.9) | 0.447 | 132 (60) | 148 (64.3) | 0.342 | ||
AG + AA | 238 (39.2) | 210 (35.9) | 150 (38.8) | 128 (36.1) | 88 (40) | 82 (35.7) | ||||||
Recessive model | AA | 21 (3.5) | 26 (4.4) | 0.382 | 11 (2.8) | 11 (3.1) | 0.837 | 10 (4.5) | 15 (6.5) | 0.36 | ||
AG + GG | 572 (99.83) | 455 (100) | 376 (97.2) | 344 (96.9) | 210 (95.5) | 215 (93.5) | ||||||
Additive model | AG | 217 (35.7) | 184 (31.5) | 0.117 | 139 (35.9) | 117 (33) | 0.447 | 78 (35.5) | 67 (29.1) | 0.342 | ||
GG + AA | 390 (64.3) | 401 (68.5) | 237 (61.2) | 227 (63.9) | 132 (60) | 148 (64.3) | ||||||
Allele | G | 955 (78.7) | 934 (79.8) | 0.484 | 613 (79.2) | 571 (80.4) | 0.558 | 342 (77.7) | 363 (78.9) | 0.666 | ||
A | 259 (21.3) | 236 (20.2) | 161 (20.8) | 139 (19.6) | 98 (22.3) | 97 (21.1) | ||||||
rs2617849 (SNP2) | Genotype | T/T | 222 (39.9) | 181 (38.8) | 0.046 | 132 (37.8) | 102 (31.1) | 0.159 | 90 (43.3) | 79 (35.3) | 0.234 | |
C/C | 74 (13.3) | 87 (15.8) | 49 (14) | 56 (17.1) | 25 (12) | 31 (13.8) | ||||||
C/T | 261 (46.9) | 284 (51.4) | 168 (48.1) | 170 (51.8) | 93 (44.7) | 114 (50.9) | ||||||
Dominant model | TT | 222 (39.9) | 181 (38.8) | 0.014* | 132 (37.8) | 102 (31.1) | 0.066 | 90 (43.3) | 79 (35.3) | 0.89 | ||
CC + CT | 335 (60.1) | 371 (67.2) | 217 (62.2) | 226 (68.9) | 118 (56.7) | 145 (64.7) | ||||||
Recessive model | CC | 74 (13.3) | 87 (15.8) | 0.242 | 49 (51.9) | 56 (17.1) | 0.276 | 25 (12) | 31 (13.8) | 0.574 | ||
TT + CT | 483 (86.7) | 465 (84.2) | 300 (86) | 272 (82.9) | 183 (88) | 193 (86.2) | ||||||
Additive model | CT | 261 (46.9) | 284 (51.4) | 0.126 | 168 (48.1) | 170 (51.8) | 0.337 | 93 (44.7) | 114 (50.9) | 0.199 | ||
CC + TT | 296 (53.1) | 268 (48.6) | 181 (51.9) | 158 (48.2) | 115 (55.3) | 110 (49.1) | ||||||
Allele | C | 409 (37.7) | 458 (41.5) | 0.021* | 266 (38.1) | 282 (43) | 0.068 | 143 (34.4) | 176 (39.3) | 0.135 | ||
T | 705 (63.3) | 646 (58.5) | 432 (61.9) | 374 (57) | 273 (65.6) | 272 (60.7) | ||||||
rs2440472 (SNP3) | Genotype | A/A | 164 (27.2) | 187 (32.7) | 0.008* | 110 (28.4) | 123 (36.1) | 0.007* | 54 (25.2) | 64 (27.7) | 0.582 | |
G/G | 144 (23.9) | 98 (17.1) | 95 (24.5) | 54 (15.8) | 49 (22.9) | 44 (19) | ||||||
A/G | 294 (48.8) | 287 (50.2) | 183 (47.2) | 164 (48.1) | 111 (51.9) | 123 (53.2) | ||||||
Dominant model | A/A | 164 (27.2) | 187 (32.7) | 0.041* | 110 (28.4) | 123 (36.1) | 0.026* | 54 (25.2) | 64 (27.7) | 0.555 | ||
GG + AG | 438 (72.8) | 385 (67.3) | 278 (71.6) | 218 (63.9) | 160 (74.8) | 167 (72.3) | ||||||
Recessive model | GG | 144 (23.9) | 98 (17.1) | 0.004* | 95 (24.5) | 54 (15.8) | 0.004* | 49 (22.9) | 44 (19) | 0.318 | ||
AA + AG | 458 (76.1) | 474 (82.9) | 293 (75.5) | 287 (84.2) | 165 (77.1) | 187 (81) | ||||||
Additive model | AG | 294 (48.8) | 287 (50.2) | 0.647 | 183 (47.2) | 164 (48.1) | 0.802 | 111 (51.9) | 123 (53.2) | 0.771 | ||
AA + GG | 308 (51.2) | 285 (49.8) | 205 (52.8) | 177 (51.9) | 103 (48.1) | 108 (46.8) | ||||||
Allele | A | 622 (51.7) | 661 (57.8) | 0.003* | 403 (51.9) | 410 (60.1) | 0.002* | 219 (51.2) | 251 (54.3) | 0.345 | ||
G | 582 (48.3) | 483 (42.2) | 373 (48.1) | 272 (39.9) | 209 (48.8) | 211 (45.7) | ||||||