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Table 4 Activities of hepatic enzymes and serum LCAT activity in SD and ExHC rats

From: Unavailability of liver triacylglycerol increases serum cholesterol concentration induced by dietary cholesterol in exogenously hypercholesterolemic (ExHC) rats

 

SD

ExHC

 

Liver enzyme activities

nmol mn-1 mg-1protein

Fatty acid synthase

37.8 ± 2.9

29.5 ± 2.1*

Malic enzyme

83.2 ± 6.1

81.6 ± 10.1

Glucose 6-phosphate dehydrogenase

90.9 ± 10.0

87.7 ± 18.4

Phosphatidate phosphohydrolase

 

Mg2+-dependent

17.4 ± 0.6

15.7 ± 1.1

Carnitine palmitoyl transferase

1.42 ± 0.13

2.52 ± 0.21*

Peroxisomal β-oxdation

9.40 ± 1.39

3.92 ± 0.75*

Serum enzyme activity

Unit ┼

LCAT

268 ± 22

251 ± 39

  1. Values are mean ± SEM; n = 5. *p < 0.05. ExHC, exogenously hypercholesterolemic; SD, Sprague–Dawley.
  2. ✝Unit of lecithin:cholesterol acyltransferase (LCAT) activity is defined as a concentration of esterified free-cholesterol at 37°C in 1 h in the operating manual of the ANASOLV® LCAT (SEKISUI Medical Co. LTD., Japan).
  3. Abbreviations: LCAT lecithin:cholesterol acyltransferase.
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Lipids in Health and Disease

ISSN: 1476-511X