Dietary pulp from Fructus Schisandra Chinensis supplementation reduces serum/hepatic lipid and hepatic glucose levels in mice fed a normal or high cholesterol/bile salt diet

Table 1 Effects of dietary supplementation with SAqFSC-P, PAqFSC-P, or bicyclol on serum lipoprotein profiles in normal and hypercholesterolemic mice

Groups	Drug concentration (%, w/w)	HDL (mmol/L)	LDL (mmol/L)	HDL/LDL (mmol/L)	LDL/HDL (mmol/L)	N-HDL (mmol/L)
*Normal mice*
Control ND	-	3.94 ± 0.21	0.71 ± 0.04	5.82 ± 0.34	0.18 ± 0.01	0.11 ± 0.11
SAqFSC-P/ND	1	3.95 ± 0.09	0.67 ± 0.03	6.02 ± 0.28	0.17 ± 0.01	0.23 ± 0.13
	9	4.00 ± 0.11	0.63 ± 0.04	6.47 ± 0.30	0.16 ± 0.01	0.25 ± 0.09
PAqFSC-P/ND	1	4.00 ± 0.15	0.63 ± 0.03	6.20 ± 0.36	0.16 ± 0.01	0.23 ± 0.06
	9	4.18 ± 0.17	0.63 ± 0.03	6.46 ± 0.29	0.16 ± 0.01	0.17 ± 0.06
Bicyclol/ND	0.025	4.17 ± 0.16	0.70 ± 0.04	6.21 ± 0.48	0.17 ± 0.02	0.10 ± 0.07
*Hypercholester-olemic mice*
Control ND	-	3.10 ± 0.12	0.20 ± 0.02	16.65 ± 1.30	0.06 ± 0.01	0.64 ± 0.03
Control HCBD	-	3.02 ± 0.12	1.08 ± 0.07^a	2.86 ± 0.17^a	0.36 ± 0.02^a	2.54 ± 0.14^a
SAqFSC-P/HCBD	1	3.15 ± 0.15	1.08 ± 0.06	3.29 ± 0.16	0.31 ± 0.02	2.17 ± 0.12
	3	3.20 ± 0.12	1.22 ± 0.09	2.90 ± 0.14	0.35 ± 0.02	2.51 ± 0.19
PAqFSC-P/HCBD	1	3.16 ± 0.10	1.09 ± 0.06	2.72 ± 0.17	0.37 ± 0.02	2.18 ± 0.10^b
	3	3.08 ± 0.10	0.93 ± 0.05	3.30 ± 0.21	0.35 ± 0.02	1.98 ± 0.11^b
Bicyclol/HCBD	0.025	3.27 ± 0.14	1.02 ± 0.07	3.41 ± 0.23	0.31 ± 0.02	2.28 ± 0.13

Experimental details were described in Figure1. Mice were fed with ND or HCBD containing SAqFSC-P, PAqFSC-P, or bicyclol at the indicated concentration for 10 days. Serum low-density lipoprotein (LDL), high-density lipoprotein (HDL), HDL/LDL, LDL/HDL, and N-HDL levels were then measured. Mouse model of hypercholesterolemia was generated by HCBD. Values given are the means ± S.E.M., with n = 10. ^aP < 0.01 vs. control ND; ^bP < 0.05 vs. control HCBD, using a one-way ANOVA follow by Dunnett’s multiple comparisons test or post-hoc analysis.

ISSN: 1476-511X