Table 2 Changes of NO production and serum level of Lp-PLA2
From: Synergistic effects of colchicine combined with atorvastatin in rats with hyperlipidemia
Variables | Sham | Control | Atorvastatin | Colchicine | Combined |
|---|---|---|---|---|---|
Before the beginning of the study | |||||
NO (μmol/L) | 8.6 ± 0.7 | 8.9 ± 0.7 | 9.2 ± 0.5 | 9.0 ± 0.6 | 8.8 ± 0.6 |
Lp-PLA2 (ng/mL) | 73.6 ± 6.7 | 78.7 ± 7.3 | 74.5 ± 6.6 | 76.2 ± 6.9 | 76.0 ± 5.7 |
6 weeks of model production | |||||
NO (μmol/L) | 8.2 ± 0.4* | 4.3 ± 0.5 | 4.1 ± 0.4 | 4.4 ± 0.6 | 4.5 ± 0.6 |
Lp-PLA2 (ng/mL) | 77.2 ± 8.1* | 164.2 ± 13.5 | 168.7 ± 11.5 | 170.3 ± 15.2 | 166.8 ± 14.3 |
2 weeks of therapy | |||||
NO (μmol/L) | 8.9 ± 0.5 | 4.4 ± 0.6# | 6.2 ± 0.7 | 6.1 ± 0.4 | 7.3 ± 0.3& |
Lp-PLA2 (ng/mL) | 80.1 ± 9.6 | 160.6 ± 10.2# | 148.3 ± 9.9 | 143.2 ± 8.6 | 130.2 ± 5.8& |