From: In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients
Parameter | Groups | Baseline/0 month | 1stmonth | 3rdmonth | 6thmonth | 9thmonth | 12thmonth | ptime | Pint. |
---|---|---|---|---|---|---|---|---|---|
Bound PAF (fmol/mL) | T | 1.66 | 1.11* | 0.90* | 1.08* | 1.12 | 0.74* | 0.010 | 0.357 |
(1.35-2.02) | (0.70-1.18) | (0.70-1.30) | (0.70-1.54) | (0.70-2.11) | (0.70-1.18) | ||||
A | 0.90 | 1.10 | 5.54* | 1.42 | 1.14 | 1.53 | 0.028 | P 3 = 0.038 | |
(0.70-6.20) | (0.70-2.41) | (0.97-17.29) | (0.78-3.85) | (0.93-1.71) | (0.78-2.39) | P 12 = 0.083 | |||
PAF-CPT in HLs (pmol/min/mg) | T | 546.50 | 336.00* | 191.50* | 232.00* | 338.50* | 288.50* | 0.009 | 0.304 |
(416.50-730.25) | (182.50-451.75) | (114.50-518.00) | (147.25-461.25) | (231.25 -381.25) | (236.50-341.75) | ||||
A | 344.50 | 257.00 | 438.00 | 344.00 | 495.00 | 445.00* | 0.085 | ||
(215.25-787.75) | (221.75-515.25) | (183.00-535.50) | (173.50-795.50) | (252.50-755.00) | (330.00-920.00) | ||||
Lyso-PAF-AT in HLs (pmol/min/mg) | T | 22.95 | 12.40 | 12.20 | 8.40* | 13.85* | 16.40* | 0.002 | 0.818 |
(11.90-26.65) | (10.75-33.27) | (8.02-28.07) | (2.22-12.92) | (8.47-17.60) | (9.77-19.75) | ||||
A | 9.15 | 10.75 | 20.60* | 10.55 | 13.50 | 12.50 | 0.141 | ||
(6.12-19.82) | (5.25-22.20) | (7.42-35.75) | (6.85-27.27) | (8.00-27.75) | (6.50-24.25) | ||||
PAF-AH in HLs (pmol/min/mg) | T | 69.17 | 55.68 | 70.71 | 54.18* | 46.32* | 45.81* | 0.002 | 0.732 |
(42.94-106.97) | (32.34-80.52) | (37.47-114.14) | (33.09-65.45) | (28.23-62.67) | (25.79-51.56) | ||||
A | 50.54 | 52.68 | 64.03* | 61.30 | 57.05 | 52.24 | 0.180 | ||
(46.57-58.78) | (34.37-72.78) | (50.80-92.62) | (32.55-75.06) | (36.49-66.05) | (40.54-61.08) | ||||
Lp-PLA2 (pmol/min/μL) | T | 29.35 | 26.15 | 34.20 | 29.10 | 26.40* | 27.15* | 0.003 | 0.017 |
(24.40-34.12) | (23.70-35.37) | (30.00-35.12) | (26.15-38.47) | (22.44-29.35) | (20.79-28.50) | ||||
A | 33.66 | 32.63 | 33.59 | 33.67 | 37.55* | 33.33 | 0.002 | P 3 = 0.038 | |
(30.30-35.89) | (27.20-36.59) | (29.32-38.15) | (27.61-35.48) | (35.67-42.43) | (31.63-40.90) | P 12 = 0.083 |