Figure 4
From: Effects of thyroxine and 1-methyl, 2-mercaptoimidazol on phosphoinositides synthesis in rat liver
Long- and short-term effects of thyroxine on phosphoinositides metabolism in rat liver. Hormone rapidly and non-genomicaly stimulates PtdInsP2 degradation, DAG accumulation and PKC/PLD activation. Hormone-induced PLC activation is followed by PtdInsP2 resynthesis, probably via phosphoinositide 5-kinase induction by newly synthesized- or PCh-derived PA. PA could further be converted to polyphosphoinositide precursor – arachidonate-contaning PtdIns under the long lag period of hormone action on the organism. PA – phosphatidic acid, CDP-DAG – cytidine diphosphate diacylglycerol, PAA – palmitic acid, AA – arachidonic acid, Ins – inositol, InsP – inositol 1-monophosphate, InsP2 – inositol 1,4-bisphosphate, InsP3 – inositol 1,4,5-trisphosphate, PCh – phosphatidylcholine.