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Figure 7 | Lipids in Health and Disease

Figure 7

From: Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol

Figure 7

A working hypothesis showing 24,25EC's role in protecting against accumulation of newly-synthesised cholesterol. Synthesis of cholesterol is accompanied by synthesis of 24,25EC in the same pathway. 24,25EC can inhibit cholesterol uptake and synthesis by suppressing SREBP activation. 24,25EC can also promote cholesterol efflux by serving as a ligand for LXR target genes, including ABCA1.

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Lipids in Health and Disease

ISSN: 1476-511X