Table 1 Changes* in body weight, waist, leptin, fat, total cholesterol, LDL cholesterol, glucose and adiponectin measurements in the course of the study.

Group

Base line

4

8

10

Over change

Placebo

96.4 ± 12.3

95.8 ± 8.2

95.1 ± 10.6

95.7 ± 15.2

-0.7

IGOB131

97.9 ± 9.1

94.3 ± 5.5 ^a

89.7 ± 4.7 ^a

85.1 ± 3.1^b

-12.8

Placebo

106.4 ± 10.8

102.7 ± 10.6

101.1 ± 14.8

101.1 ± 15.8^b

-5.3

IGOB131

105.1 ± 6.3

98.0 ± 8.4^a

90.1 ± 8.70^a

88.1 ± 7.6

-16.19

Placebo

31.3 ± 1.8

29.4 ± 1.4

28.1 ± 1.8

28.4 ± 1.8

-2.9

IGOB131

32.9 ± 1.6

18.1 ± 1.3^a

16.8 ± 1.2^a

16.9 ± 1.3^b

-16.0

Placebo

34.7 ± 8.6

33.31 ± 10.9

32.9 ± 11.9

32.7 ± 15.7

-1.99

IGOB131

34.2 ± 7.9

31.6 ± 5.4^a

28.2 ± 6.6^a

27.9 ± 5.5^a

-6.3

Placebo

77.4 ± 9.2

76.5 ± 8.9

74.1 ± 9.3

73.7 ± 8.3

-3.75

IGOB131

82.2 ± 8.1

71.8 ± 5.9^b

64.7 ± 8.9^b

59.8 ± 5.0^b

-22.44

Placebo

145.2 ± 22.4

143.9 ± 12.2

142.1 ± 13.6

142.4 ± 12.1

-2.8

IGOB131

151.7 ± 18.5

133.7 ± 16.6^a

120.1 ± 11.9 ^a

111.9 ± 5.8^a

-39.8

Placebo

1.46 ± 0.05

1.46 ± 0.04

1.445 ± 0.03

1.455 ± 0.05

-0.01

IGOB131

1.49 ± 0.041

0.91 ± 0.05^a

0.71 ± 0.04^b

0.72 ± 0.05^b

-0.78

Placebo

81.4 ± 9.6

79.5 ± 10.1

77.8 ± 9.4

77.1 ± 7.8

-4.3

85.55 ± 5.59

76.6 ± 10.3^a

68.7 ± 9.3^a

66.3 ± 4.9^a

-19.3

Placebo

12.1 ± 3.2

15.2 ± 3.5

14.6 ± 3.5

14.94 ± 3.9

+ 2.8

IGOB131

12.2 ± 3.0

24.8 ± 3.8^a

31.0 ± 4.0^b

31.6 ± 3.9^a

+ 19.4