Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults

Table 3 Comparison of areas under the ROC curves (95% CI) for potential markers of insulin resistance (HOMA-IR§ > 2.5) of subjects categorized by body mass index

	AUC (95% CI)
	Total	Non-obese		Overweight
Body mass index Characteristics	All N = 1,393	P -value	<25.0 kg/m² N = 1,042	P -value	>25.0 kg/m² N = 351	P -value
Triglycerides (mg/dL)	0.69 (0.45-0.73)	<0.001	0.66 (0.59-0.72)	<0.001	0.64 (0.58-0.71)	<0.001
HDL cholesterol (mg/dL)	0.33 (0.28-0.37)	<0.001	0.31 (0.24-0.38)	<0.001	0.41 (0.35-0.48)	0.009
LDL cholesterol (mg/dL)	0.61 (0.56-0.65)	<0.001	0.65 (0.58-0.72)	<0.001	0.54 (0.48-0.61)	0.188
Triglycerides/HDL cholesterol ratio	0.70 (0.66-0.75)	<0.001	0.69 (0.62-0.75)	<0.001	0.64 (0.57-0.70)	<0.001
Non-HDL cholesterol (mg/dL)	0.66 (0.61-0.70)	<0.001	0.69 (0.62-0.75)	<0.001	0.59 (0.52-0.65)	0.011
LDL-cholesterol/HDL-cholesterol ratio	0.69 (0.65-0.73)	<0.001	0.74 (0.66-0.80)	<0.001	0.58 (0.51-0.65)	0.021

ROC, receiver operating characteristics; HOMA-IR, homeostasis of minimal assessment of insulin resistance; CI, confidence interval; AUC, area under ROC curve; HDL, high-density lipoprotein; LDL, low-density lipoprotein. §HOMA-IR was calculated using the following formula; {fasting blood glucose (mg/dL) X immuno-reactive insulin (mU/mL)}/405.

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