Genetic and diet effects on Ppar-α and Ppar-γ signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity

Table 1 Body composition and serum parameters in 10 week old BFMI and B6 mice on SMD and BFMI mice on HFD

Trait	B6	BFMI on SMD	BFMI on HFD
Body weight (g)	23.4 (1.4)	39.2 (2.7)*	47.8 (2.3)+
Body composition traits
Body lean mass (g)	19.97 (0.95)	29.29 (1.71)*	31.43 (1.38)+
Body fat mass (g)	0.97 (0.31)	8.84 (2.26)*	14.56 (2.26)+
Total white fat tissue (g)	1.11 (0.26)	7.70 (1.70)*	12.10 (0.95)+
Reproductive fat pad (g)	0.23 (0.05)	1.96 (0.43)*	2.26 (0.53)
Renal fat pad (g)	0.07 (0.03)	0.69 (0.13)*	1.01 (0.19)+
Subcutaneous fat pad (g)	0.50 (0.15)	2.57 (1.02)*	4.42 (1.42)+
Liver (g)	1.16 (0.15)	2.19 (0.22)*	3.33 (0.46)+
Serum parameter traits
Triglycerides (mg/dl)	123 (63)	277 (95)*	245 (97)
Total cholesterol (mg/dl)	103 (20)	100 (11)	177 (24)+

SMD, standard maintenance diet; HFD, high-fat diet; values represent mean values with standard deviation in parenthesis of B6 on SMD (n = 15), BFMI on SMD (n = 11), and BFMI on HFD (n = 12). Serum parameters were obtained after a fasting period of two hours (BFMI on SMD (n = 8), BFMI on HFD (n = 8), and B6 (n = 12)). Asterisks indicate significant differences between BFMI860 and B6. Except for cholesterol all values were significantly different between B6 and BFMI mice on SMD. + indicates significant differences between standard maintenance and high-fat diet within line BFMI860 (P < 0.05).

ISSN: 1476-511X