Table 1 Baseline demographics and clinical characteristics

Subjects in population

75

77

152

Male, n (%)

46 (61.3)

48 (62.3)

94 (61.8)

Mean age, yrs (SD)

59.3 (10.8)

60.0 (9.7)

59.6 (10.2)

Mean body mass index, kg/m2 (SD)

26.2 (5.3)

25.7 (3.9)

25.9 (4.6)

Coexisting diseases, yes; n (%)

70 (93.3)

74 (96.1)

144 (94.7)

Selected coexisting diseases, n (%):

 Cardiac disease other than CHD

3 (4.0)

4 (5.2)

7 (4.6)

 Hypertension

37 (49.3)

35 (45.5)

72 (47.4)

 Hepatic steatosis

24 (32.0)

26 (33.8)

50 (32.9)

 Hyperuricaemia

6 (8.0)

7 (9.1)

13 (8.6)

 Obesity

2 (2.7)

1 (1.3)

3 (2.0)

Concomitant medications, yes; n (%)

75 (100)

77 (100)

152 (100)

Selected concomitant medications, n (%):

 Oral anti diabetes agents

70 (93.3)

72 (93.5)

142 (93.4)

 Dipeptidyl peptidase-4 inhibitors

39 (52.0)

29 (37.7)

68 (44.7)

 Sulfonylureas

27 (36.0)

22 (28.6)

49 (32.2)

 Glinides

3 ( 4.0)

10 (13.0)

13 (8.6)

 Thiazolidine

12 (16.0)

9 (11.7)

21 (13.8)

 Biguanides

34 (45.3)

28 (36.4)

62 (40.8)

 Alpha-glucosidase inhibitors

24 (32.0)

24 (31.2)

48 (31.6)

 Thiazolidine + Biguanides

1 (1.3)

-

1 (0.7)

 Glinides + Alpha-glucosidase inhibitors

2 (2.7)

-

2 (1.3)

Insulin administration yes; n (%)

23 (30.7)

24 (31.2)

47 (30.9)

Hypertension agents

35 (46.7)

30 (39.0)

65 (42.8)

 Calcium channel blocker

19 (25.3)

15 (19.5)

34 (22.4)

 Beta blocker

2 (2.7)

1 (1.3)

3 (2.0)

 Alpha blocker

5 (6.7)

2 (2.6)

7 (4.6)

 ARB

22 (29.3)

17 (22.1)

39 (25.7)

 Diuretic

3 (4.0)

1 (1.3)

4 (2.6)

 ACE inhibitor

2 (2.7)

4 (5.2)

6 (3.9)

 ARB + Diuretic

3 (4.0)

1 (1.3)

4 (2.6)

 ARB + Calcium channel blocker

3 (4.0)

3 (3.9)

6 (3.9)

Mean duration of diabetes, months (SD)

88.9 (74.0)

94.9 (93.8)

92.0 (84.4)

Mean HbA1c, % (SD)

7.0 (0.6)

7.0 (0.6)

7.0 (0.6)

<7.4%, n (%)

56 (74.7)

58 (75.3)

114 (75.0)

≥7.4%, <8.4%, n (%)

19 (25.3)

19 (24.7)

38 (25.0)

Mean glycoalbumin, % (SD)

17.3 (2.3)

17.4 (2.6)

17.3 (2.4)

Mean fasting plasma glucose, mg/dL (SD)

125.7 (22.2)

126.9 (17.3)

126.3 (19.8)

Mean LDL-C, mg/dL (SD)

138.6 (11.2)

139.4 (10.4)

139.0 (10.8)

Mean total cholesterol, mg/dL (SD)

217.6 (16.2)

219.0 (21.1)

218.3 (18.8)

Mean triglycerides, mg/dL (SD)

119.6 (57.3)

129.5 (63.8)

124.6 (60.7)

Mean HDL-C, mg/dL (SD)

55.0 (13.5)

53.7 (12.8)

54.3 (13.1)

Mean non-HDL-C, mg/dL (SD)

162.6 (15.2)

165.3 (16.4)

164.0 (15.9)