The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia

Table 3 Change in lipid parameters observed with omega-3 carboxylic acids, omega-3 ethyl esters, and icosapent ethyl in statin-treated patients with high triglyceride levels (triglyceride level ≥ 200 mg/dL and < 500 mg/dL)

	OM3CA (Epanova) [22]			OM3EE (Lovaza) [20]		IPE (Vascepa) [24]
Parameter	Statin^† + olive oil (n = 215)	Statin^† + OM3CA 2 g/day (n = 215)	Statin^† + OM3CA 4 g/day (n = 215)	Simvastatin 40 mg + vegetable oil (n = 132)	Simvastatin 40 mg + OM3EE 4 g/day (n = 122)	Statin^‡ + placebo^§ (n = 277)	Statin^‡ + IPE 2 g/day (n = 234)	Statin^‡ + IPE 4 g/day (n = 226)
TG
BL, mg/dL	280	284	287	286.7	282.0	259.0	254	264.8
% change	−5.9	−14.6***	−20.6***	−3.5	−28.2***	5.9	−5.6**	−17.5***
Non-HDL-C
BL, mg/dL	135	140	139	141.3	135.8	128	128	128
% change	−0.9	−3.9*	−6.9***	−1.5	−7.9***	9.8	2.4	−5.0***
HDL-C
BL, mg/dL	38.8	38.7	38.8	44.7	47.3	39.0	38.0	37.0
% change	2.2	2.6	3.3	−1.1	4.1***	4.8	0.0	−1.0**
Total cholesterol
BL, mg/dL	174	179	178	186.0	183.1	168.0	169	167
% change	0.5	−1.7*	−3.8***	−1.5	−4.7**	9.1	2.1	−3.2***
VLDL-C
BL, mg/dL	45.7	46.9	47.2	53.2	52.1	42.0	43.0	44.0
% change	−5.9	−14.3**	−21.5***	−4.8	−23.8***	15.0	1.6	−12.1***
LDL-C
BL, mg/dL	91.7	92.3	93.6	92.3	89.2	84.0	82.0	82.0
% change	1.1	4.6*	1.3	−1.9	3.4	8.8	2.4	1.5**
ApoB
BL, mg/dL	93.8	94.5	95.9	86.8	85.0	91.0	91.0	93.0
% change	0.3	0.7	−2.1*	−1.2	−3.8*	7.1	1.6	−2.2***

For IPE, data are presented as median; for OM3CA, data are presented as least-squares mean; for OM3EE, data are presented as geometric mean. P-values versus placebo: *P < 0.05; **P < 0.01; ***P < 0.001. ^†Statins included lovastatin 20–40 mg, pravastatin 10–80 mg, fluvastatin 20–80 mg, simvastatin 10–40 mg, atorvastatin 10–40 mg, and rosuvastatin 10–40 mg, alone or in combination with ezetimibe; ^‡Statins included simvastatin, atorvastatin, and rosuvastatin, alone or in combination with ezetimibe. ^§Placebo not specified
ApoB apolipoprotein B, BL baseline, HDL-C high-density lipoprotein cholesterol, IPE icosapent ethyl, LDL-C low-density lipoprotein cholesterol, OM3CA omega-3 carboxylic acids, OM3EE omega-3 ethyl esters, TG triglyceride, VLDL-C very-low-density lipoprotein cholesterol

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