Table 5 Association between plasma IL-6 concentration and metabolic syndrome, and the mediation effect of MS components

MetS-IDF

Age (years)

1.072 (1.040- 1.105)

1.072 (1.038-1.108)

1.076 (1.042- 1.111)

1.072 (1.037- 1.109)

1.091 (1.053- 1.129)

1.068 (1.032- 1.105)

Sex (men)

0.357 (0.205- 0.624)

0.405 (0.223-0.738)

0.345 (0.190- 0.626)

0.957 (0.481- 1.907)

0.690 (0.364- 1.309)

0.493 (0.262- 0.927)

IL-6 (pg/ml)

1.086 (0.975- 1.210)

1.051 (0.935-1.182)

1.054 (0.934- 1.191)

1.021 (0.894- 1.166)

0.968 (0.853- 1.099)

1.033 (0.907- 1.176)

Insulin (mU/L)

-

1.154 (1.090-1.221)

-

-

-

-

BMI (kg/m²)

-

-

1.139 (1.073- 1.209)

-

-

-

Waist circumference (cm)

-

-

-

1.097 (1.065- 1.131)

-

-

HDL-cholesterol (mmol/L)

-

-

-

-

0.893 (0.861- 0.925)

-

Triglycerides (mmol/L)

-

-

-

-

-

1.023 (1.015- 1.030)

MetS-AHA/NHLBI

Age (years)

1.066 (1.034- 1.098)

1.067 (1.033-1.103)

1.072 (1.038- 1.108)

1.068 (1.031- 1.105)

1.090 (1.051- 1.131)

1.063 (1.026- 1.102)

Sex (men)

0.395 (0.224- 0.695)

0.456 (0.246-0.844)

0.372 (0.201- 0.689)

1.171 (0.573- 2.395)

0.923 (0.467- 1.824)

0.579 (0.299- 1.123)

IL-6 (pg/ml)

1.064 (0.954- 1.186)

1.024 (0.907-1.156)

1.019 (0.894- 1.162)

0.983 (0.854- 1.131)

0.918 (0.805- 1.048)

0.995 (0.870- 1.139)

Insulin (mU/L)

-

1.168 (1.103-1.237)

-

-

-

-

BMI (kg/m²)

-

-

1.167 (1.094- 1.244)

-

-

-

Waist circumference (cm)

-

-

-

1.110 (1.075- 1.146)

-

-

HDL-cholesterol (mmol/L)

-

-

-

-

0.865 (0.830- 0.902)

-

Triglycerides (mmol/L)

-

-

-

-

-

1.026 (1.018- 1.034)