The role of background diet on the effects of eicosapentaenoic acid and docosahexaenoic acid supplementation in healthy pre-menopausal women: a randomized, cross-over, controlled study

Gomes, Megan Arnold; Jia, Xiaoyuan; Kolenski, Iris; Duncan, Alison M.; Meckling, Kelly A.

doi:10.1186/s12944-016-0341-1

Lipids in Health and Disease

Table 6 Fatty acid composition (% by weight) in red blood cell membranes

From: The role of background diet on the effects of eicosapentaenoic acid and docosahexaenoic acid supplementation in healthy pre-menopausal women: a randomized, cross-over, controlled study

	Baseline (mean ± SE)	Low-fat diet (mean ± SE)	p1	Habitual diet (mean ± SE)	p2
	(n = 41)	(n = 41)	p1	(n = 8)	p2
C14:0	0.38 ± 0.07	0.36 ± 0.07	0.84	0.40 ± 0.04	0.81
C14:1	0.23 ± 0.18	0.39 ± 0.07	<0.01	0.45 ± 0.14	0.35
C15:0	0.22 ± 0.04	0.20 ± 003	0.69	0.19 ± 0.03	0.56
C16:0	23.59 ± 1.31	23.71 ± 1.44	0.95	22.6 ± 1.31	0.60
C16:1	0.22 ± 0.07	0.30 ± 0.10	<0.01	0.32 ± 0.04	0.24
C18:0	12.15 ± 0.81	12.04 ± 0.85	0.92	14.07 ± 0.51	<0.05
C18:1	17.04 ± 1.07	17.44 ± 1.25	<0.05	18.68 ± 0.43	0.18
C18:2n-6	12.20 ± 1.53	10.56 ± 2.13	<0.01	10.56 ± 0.86	0.36
C18:3n-6	0.04 ± 0.04	0.04 ± 0.03	1.0	0.03 ± 0.02	1.0
C18:3n-3	0.19 ± 0.06	0.18 ± 0.06	0.91	0.22 ± 0.06	0.73
C18:4n-3	0.02 ± 0.02	0.02 ± 0.02	1.0	0.10 ± 0.02	<0.05
C20:0	0.20 ± 0.15	0.16 ± 0.07	0.81	0.05 ± 0.02	<0.05
C20:1	0.31 ± 0.14	0.23 ± 0.07	<0.01	0.23 ± 0.04	0.59
C20:2n-6	0.13 ± 0.12	0.02 ± 0.02	<0.01	0.21 ± 0.06	<0.05
C20:3n-6	1.43 ± 0.34	1.25 ± 0.27	<0.01	1.34 ± 0.23	0.83
C20:4n-6 (AA)	12.96 ± 1.28	11.98 ± 1.55	<0.01	12.16 ± 1.21	0.66
C20:3n-3	0.01 ± 0.02	0.01 ± 0.01	1.0	0.01 ± 0.01	1.0
C20:4n-3	0.05 ± 0.04	0.05 ± 0.03	1.0	0.05 ± 0.05	1.0
C20:5n-3 (EPA)	0.80 ± 0.35	2.64 ± 0.62	<0.01	2.27 ± 0.4	P < 0.05
C22:0	1.15 ± 0.31	0.76 ± 0.19	<0.05	0.00 ± 0.00	<0.01
C22:1	0.99 ± 1.00	0.44 ± 0.16	<0.01	0.43 ± 0.33	0.60
C22:2n-6	0.10 ± 0.07	0.10 ± 0.04	1.0	0.00 ± 0.00	<0.01
C22:4n-6	3.08 ± 0.59	2.39 ± 0.53	<0.01	2.11 ± 0.44	0.21
C22:5n-6	0.33 ± 0.26	0.38 ± 0.66	0.94	0.02 ± 0.03	0.26
C22:5n-3	2.25 ± 0.44	3.74 ± 0.72	<0.01	3.70 ± 0.46	0.07
C22:6n-3 (DHA)	4.37 ± 1.09	6.91 ± 1.03	<0.01	6.08 ± 1.04	<0.05
C24:0	1.74 ± 1.30	1.89 ± 1.33	0.94	1.47 ± 0.16	<0.01
C24:1	3.78 ± 2.42	1.93 ± 0.45	<0.01	2.59 ± 0.46	<0.05
Saturated	39.44 ± 2.30	39.12 ± 1.71	0.91	38.75 ± 1.81	0.82
MUFA	22.58 ± 3.13	20.73 ± 1.48	0.59	21.04 ± 1.41	<0.05
PUFA	37.97 ± 2.71	40.13 ± 2.61	<0.01	39.94 ± 2.95	0.63
n-3	7.63 ± 1.61	13.57 ± 1.96	<0.01	12.03 ± 1.62	<0.05
n-6	30.20 ± 2.38	26.40 ± 2.14	<0.01	26.41 ± 1.90	0.23
n-3:n-6	0.25 ± 0.02	0.51 ± 0.02	<0.01	0.46 ± 0.007	<0.05
AA/EPA	19.01 ± 7.77	4.86 ± 1.74	<0.01	5.30 ± 1.04	0.10

Data are expressed as a percentage of total fatty acids ± standard error. p1, significance of paired t-test of baseline vs. after low-fat diet, p2, significance of paired t-test of after low-fat diet vs. after habitual diet

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