Table 2 Functional annotation of upregulated genes in MCF-7/CerS4 cells using Transcription_Factor_PPIs.
From: Ceramide synthase 4 overexpression exerts oncogenic properties in breast cancer
Transcription_Factor_PPIs term | Overlap | P-value | Adjusted P-value | Odds ratio | Combined score |
|---|---|---|---|---|---|
ERG | 17 (41) | 9.65E-13 | 2.39E − 10 | 14.82751832 | 410.2284253 |
MYC | 93 (957) | 8.40E-12 | 8.14E − 10 | 2.350115741 | 59.93357056 |
ESR1 | 87 (871) | 9.85E-12 | 8.14E − 10 | 2.416094206 | 61.23323517 |
TP53 | 65 (628) | 1.12E-09 | 6.97E − 08 | 2.47915748 | 51.08547827 |
SP1 | 37 (263) | 1.68E-09 | 8.35E − 08 | 3.466933479 | 70.04192295 |
EP300 | 51 (473) | 1.93E-08 | 7.97E − 07 | 2.573094527 | 45.70841512 |
RAD21 | 32 (237) | 5.67E-08 | 2.01E − 06 | 3.29078076 | 54.90623716 |
NFKB1 | 33 (254) | 8.98E-08 | 2.78E − 06 | 3.148774636 | 51.09018537 |
SMAD3 | 41 (375) | 3.30E-07 | 9.09E − 06 | 2.59627134 | 38.74730225 |
HDAC2 | 40 (387) | 1.92E-06 | 4.77E − 05 | 2.433615236 | 32.03028341 |