Skip to main content

Table 3 Functional annotation of upregulated genes shared between MCF-7/CerS4 and MCF-7/ADR cells using MSigDB_Hallmark_2020.

From: Ceramide synthase 4 overexpression exerts oncogenic properties in breast cancer

MSigDB Hallmark 2020 term

Overlap

P-value

Adjusted P-value

Odds ratio

Combined score

Epithelial−Mesenchymal Transition

15 (200)

3.94E − 15

1.42E-13

23.52782194

780.3360494

TNF-α Signaling via NF-κB

14 (200)

9.13E − 14

1.64E-12

21.52360916

646.2376942

Hypoxia

10 (200)

1.03E − 08

1.24E-07

14.22278298

261.5745424

Complement

7 (200)

1.97E − 05

1.77E-04

9.412871557

102.0059035

Apical Junction

6 (200)

1.85E − 04

1.11E-03

7.921944035

68.10278008

Inflammatory Response

6 (200)

1.85E − 04

1.11E-03

7.921944035

68.10278008

IL-2/STAT5 Signaling

5 (199)

1.44E − 03

4.81E-03

6.516983875

42.65610088

mTORC1 Signaling

5 (200)

1.47E − 03

4.81E-03

6.483234714

42.29192897

E2F Targets

5 (200)

1.47E − 03

4.81E-03

6.483234714

42.29192897

p53 Pathway

5 (200)

1.47E − 03

4.81E-03

6.483234714

42.29192897

  1. Functional annotation for the top 10 most significant of 83 upregulated genes (Fig. 8D) shared between MCF-7/CerS and MCF-7/ADR, obtained using Enrichr against the MSigDB_Hallmark_2022 library. IL: interleukin; mTORC1: mammalian target of rapamycin complex 1; NF-κB: nuclear factor kappa B; STAT5: signal transducer and activator of transcription 5; TNF-α: tumor necrosis factor-alpha
Back to article page

Lipids in Health and Disease

ISSN: 1476-511X