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Table 3 The levels of systemic inflammatory indicators of MAFLD-only, NAFLD-only, and overlap- MAFLD/NAFLD

From: Shift in prevalence and systemic inflammation levels from NAFLD to MAFLD: a population-based cross-sectional study

Indicators

Non-MAFLD/NAFLD (n = 4342)

MAFLD-only (n = 198)

NAFLD-only (n = 46)

overlap-MAFLD/NAFLD (n = 2132)

Age, years

57.0 (49.0, 65.0)

56.0 (48.0, 65.0)

52.0 (46.0, 57.0)

59.0 (52.0, 66.0) *

Sex

   

*

 Male

1477 (34.0)

180 (90.9)

23 (50.0)

648 (30.4)

 Female

2865 (66.0)

18 (9.1)

23 (50.0)

1484 (69.6)

T2DM

   

*

 No

3819 (88.0)

148 (74.8)

46 (100.0)

1417 (66.5)

 Yes

523 (12.0)

50 (25.2)

0 (0.0)

715 (33.5)

Hypertension

   

*

 No

2652 (61.1)

68 (34.3)

42 (91.3)

822 (38.6)

 Yes

1690 (38.9)

130 (65.7)

4 (8.7)

1310 (61.4)

Hyperlipidaemia

   

*

 No

3004 (69.2)

102 (51.5)

35 (76.1)

1082 (50.8)

 Yes

1338 (30.8)

96 (48.5)

11 (23.9)

1050 (49.3)

BMI, kg/m2

   

*

 < 18.5

160 (3.7)

1 (0.5)

2 (4.3)

0 (0.0)

 18.5–23.9

2804 (64.6)

33 (16.7)

44 (95.7)

384 (18)

 24.0–27.9

1216 (28)

114 (57.6)

0 (0.0)

1188 (55.7)

  ≥ 28.0

162 (3.7)

50 (25.2)

0 (0.0)

560 (26.3)

Central obesity

   

*

 No

2884 (66.4)

56 (28.3)

46 (100.0)

451 (21.2)

 Yes

1458 (33.6)

142 (71.7)

0 (0.0)

1681 (78.8)

WC, cm

79.5 (73.8, 85.2)

92.7 (88.3, 98.0)

76.45 (74.8, 81.2)

89 (83.6, 94.3) *

Hipline, cm

92.0 (88.4, 96.0)

98.0 (94.0, 101.5)

91.0 (89.0, 92.5)

97.1 (93.5, 101.2) *

SBP, mmHg

128.5 (116.5, 143.0)

137.5 (125.0, 151.5)

116.3 (109.5, 124.0)

138.3 (125.0, 152.5) *

DBP, mmHg

82.0 (75.5, 89.5)

90.5 (83.0, 98.5)

78.3 (75.5, 83.0)

88.0 (81.0, 94.5) *

TG, mmol/L

1.0 (0.74, 1.29)

1.6 (1.2, 2.2)

1.1 (0.9, 1.4)

1.5 (1.1, 2.0) *

HDL-c, mmol/L

1.7 (1.4, 1.9)

1.4 (1.2, 1.6)

1.5 (1.4, 1.7)

1.5 (1.3, 1.7) *

FBG, mmol/L

4.9 (4.5, 5.3)

5.2 (4.7, 6.0)

4.6 (4.5, 4.9)

5.2 (4.8, 6.1) *

2 h PG, mmol/L

6.9 (5.8, 8.4)

7.7 (6.6, 9.7)

6.3 (5.3, 7.3)

8.3 (6.7, 10.5) *

FINs

5.9 (4.2, 8.2)

9.3 (6.7, 13.9)

6.3 (3.9, 8.3)

10.1 (7.3, 13.5) *

ALT, U/L

18.0 (14.0, 23.0)

25.0 (20.0, 38.0)

19.5 (15.0, 26.0)

23.0 (18.0, 31.0) *

AST, U/L

21.0 (18.0, 26.0)

23.0 (19.0, 28.0)

22.0 (17.0, 24.0)

22.0 (19.0, 26.0) *

Alcohol intake, g/d

37.2 (15.1, 96.5)

86.1 (45.2, 167.3)

15.1 (15.1, 15.1)

5.1 (2.6, 14.7) *

Indicators

Non-FLD (n = 4342)

MAFLD-only (n = 198)

NAFLD-only (n = 46)

overlap-FLD (n = 2132)

CRP, mg/L

1.00 (0.68, 1.75)

1.43 (0.89, 2.43)

1.10 (0.69, 1.51)

1.39 (0.87, 2.51) *

WBC, 10^9/L

5.52 (4.72, 6.55)

6.23 (5.42, 7.25)

5.30 (4.80, 6.55)

6.11 (5.30, 7.11) *

LYMPH, 10^9/L

1.92 (1.58, 2.32)

2.18 (1.74, 2.55)

1.99 (1.71, 2.25)

2.17 (1.82, 2.61) *

NEUT, 10^9/L

3.05 (2.46, 3.84)

3.47 (2.93, 4.28)

2.98 (2.53, 3.70)

3.36 (2.76, 4.13) *

MONO, 10^9/L

0.33 (0.27, 0.41)

0.39 (0.32, 0.48)

0.33 (0.30, 0.40)

0.35 (0.29, 0.42) *

MPV, fL

10.60 (10.00, 11.20)

10.45 (9.90, 11.10)

10.45 (10.10, 11.50)

10.60 (10.00, 11.20)

ALB, g/L

48.70 (46.90, 50.50)

49.35 (47.40, 51.20)

49.10 (47.80, 51.00)

48.90 (47.30, 50.70) *

NLR

1.61 (1.22, 2.07)

1.64 (1.32, 2.05)

1.51 (1.30, 1.84)

1.53 (1.20, 1.96) *

d_NLR

1.28 (1.00, 1.62)

1.25 (1.08, 1.57)

1.22 (1.05, 1.50)

1.24 (0.99, 1.57)

PLR

125.63 (100.00, 156.13)

111.59 (88.33, 142.07)

120.92 (109.89, 147.29)

115.85 (94.82, 141.97) *

SII

380.65 (277.99, 525.27)

387.30 (297.08, 522.16)

397.72 (295.95, 486.51)

386.46 (292.44, 517.01)

SIRI

0.52 (0.36, 0.75)

0.65 (0.48, 0.89)

0.49 (0.39, 0.62)

0.54 (0.39, 0.75) *

LMR

5.88 (4.68, 7.32)

5.46 (4.35, 6.68)

6.15 (4.96, 6.93)

6.28 (5.12, 7.68) *

ALI

696.28 (528.05, 916.81)

793.54 (629.4, 1003.11)

693.49 (571.58, 839.64)

842.87 (649.39, 1081.07) *

CA

0.02 (0.01, 0.04)

0.03 (0.02, 0.05)

0.02 (0.01, 0.03)

0.03 (0.02, 0.05) *

  1. Data are presented as median with the interquartile range [M (P25-P75)], or frequency (percentage) [n (%)]
  2. T2DM type 2 diabetes mellitus, WC waist circumference, BMI body mass index, SBP systolic blood pressure, DBP diastolic pressure, TG triglyceride, HDL-C high-density lipoprotein cholesterol, FBG fasting blood glucose, 2h PG 2-h post-load blood glucose, FINs Fasting insulin, ALT alanine aminotransferase, AST aspartate aminotransferase, CRP C-reactive protein, WBC white blood cell, LYMPH lymphocyte, NEUT neutrophils, MONO monocyte, MPV mean platelet volume, ALB albumin, NLR neutrophils-to-lymphocyte ratio, SII systemic immune inflammation index, SIRI systemic immune inflammation response index
  3. *P < 0.05 for the comparison of MAFLD-only, NAFLD-only, and overlap-FLD by Kruskal–Wallis test or Chi-squared test
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Lipids in Health and Disease

ISSN: 1476-511X