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Fig. 8 | Lipids in Health and Disease

Fig. 8

From: High-fat stimulation induces atrial neural remodeling by reducing NO production via the CRIF1/eNOS/P21 axi

Fig. 8

Trimetazidine inhibits neural remodeling by promoting eNOS protein expression. (A, B) NO content in the supernatant and protein expression of eNOS after stimulation of cardiomyocytes using 0, 10, 50, and 100 µM TMZ. (C) NO content in the supernatant after PA stimulation in a culture model with the addition of TMZ. (D, E) WB detected the protein expression of P21, PGP9.5, and TH in lower-layer PC12 neuronal cells after PA stimulation in a culture model with the addition of TMZ; EdU assay of the proliferation level of lower layer PC12 neuronal cells (20X). Scale bar = 100 μm

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