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Table 2 Basic characteristics in subgroups of newly diagnosed T2DM

From: Characteristics of glucolipid metabolism and complications in novel cluster-based diabetes subgroups: a retrospective study

Variables

MARD

MOD

SIRD

SIDD

P

TC

(mmol/L)

4.42(3.73,4.97)

4.31(3.73,4.99)

4.57(3.92,5.52)

4.87(4.14,5.53)ab

 < 0.001

TG

(mmol/L)

1.59(1.12,2.38)

1.69(1.33,2.39)

2.63(1.53,4.04)ab

1.85(1.33,2.95)ac

 < 0.001

LDL

(mmol/L)

2.94(2.41,3.51)

3.01(2.45,3.52)

2.99(2.54,3.67)

3.23(2.72,3.84)ab

0.009

HDL

(mmol/L)

1.09(0.96,1.30)

1.08(0.92,1.28)

0.99(0.81,1.20)a

1.14(0.95,1.43)c

 < 0.001

TyG

7.65(7.24,8.15)

7.56(7.30,7.90)

8.77(8.14,9.23)ab

8.31(7.95,8.78)ab

 < 0.001

TG/HDL

1.30(0.89,2.37)

1.52(1.12,2.31)

2.34(1.45,4.55)ab

1.55(1.04,2.69)c

 < 0.001

HbA1C(%)

8.51(7.20,10.32)

7.32(6.51,8.42)a

11.42(10.15,12.41)ab

11.61(10.62,12.81)ab

 < 0.001

FPG

(mmol/L)

8.41(7.19,9.72)

7.04(6.43,8.25)a

14.28(11.91,17.18)ab

13.81(12.12,16.16)ab

 < 0.001

FINS

(mU/L)

6.77(4.49,8.95)

13.17(10.62,16.66)a

13.72(10.87,17.19)a

5.65(3.89,7.33)bc

 < 0.001

FCP

(ng/ml)

1.35(1.04,1.75)

2.26(1.88,2.62)a

1.99(1.13,2.45)ab

1.16(0.86,1.55)bc

 < 0.001

2hPG

(mmol/L)

10.64(8.21,14.35)

10.80(8.27,13.17)

14.11(8.87,18.72)ab

12.43(9.32,17.90)ab

 < 0.001

2hINS

(mU/L)

28.57(16.87,42.11)

53.25(33.24,84.34)a

42.39(26.44,57.89)ab

30.85(13.29,45.54)bc

 < 0.001

2hCP

(ng/ml)

3.43(2.31,4.94)

6.22(4.49,7.99)a

2.82(1.93,3.78)b

1.96(1.32,2.65)abc

 < 0.001

MHR

0.33(0.26,0.45)

0.36(0.28,0.46)

0.40(0.28,0.53)a

0.31(0.23,0.43)cb

 < 0.001

DPN

n(%)

157(93.51%)

126(92.63%)

95(93.14%)

131(92.92%)

0.994

DR

n(%)

9(5.41%)

4(2.92%)

5(4.93%)

9(6.42%)

0.605

NAFLD

n(%)

83(49.42%)

98(72.14%)a

76(74.53%)a

64(45.45%)bc

 < 0.001

ASCVD

n(%)

7(4.23%)

15(11.04%)

10(9.82%)

4(2.83%)b

0.012

CKD

n(%)

73(43.54%)

75(55.13%)

57(55.92%)

58(41.13%)

0.025

PVD

n(%)

121(72.00%)

93(68.44%)

61(59.85%)

85(60.34%)

0.077

  1. Continuous variables that follow a Gaussian distribution are presented as the mean (standard deviation), while skewed distributed continuous variables are presented as the median (interquartile range). All categorical variables were represented by numbers or proportions. Group comparisons of continuous variables were performed using ANOVA or the Mann–Whitney U test. When comparing pairwise, the least significant difference method is used. Group comparisons of categorical variables were conducted using the chi-square test. For multiple comparisons of proportions among multiple groups, Bonferroni correction is used to adjust the significance level. When p < 0.05, the difference is considered statistically significant
  2. Abbreviations: TC total cholesterol, TG triglycerides, LDL low-density lipoprotein, HDL high-density lipoprotein, TyG triglyceride glucose index, TG/HDL triglycerides to high-density lipoprotein ratio, MHR monocyte-to-high-density lipoprotein cholesterol ratio, HbA1C glycated hemoglobin, FPG fasting plasma glucose, FINS fasting insulin, FCP fasting C-peptide, 2hPG 2-h postprandial plasma glucose, 2hINS 2-h postprandial insulin, 2hCP 2-h postprandial C-peptide, DPN diabetic peripheral neuropathy, DR diabetic retinopathy, NAFLD non-alcohol Fatty Liver Disease, ASCVD arteriosclerotic cardiovascular disease, CKD chronic kidney disease, PVD peripheral vascular disease
  3. ap < 0.05 represents a comparison of MOD, SIRD, and SIDD groups with the MARD group
  4. bp < 0.05 represents a comparison of SIRD and SIDD groups with the MOD group
  5. cp < 0.05 represents a comparison of the SIDD group with the SIRD group
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Lipids in Health and Disease

ISSN: 1476-511X