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Fig. 2 | Lipids in Health and Disease

Fig. 2

From: Role of arachidonic acid metabolism in intervertebral disc degeneration: identification of potential biomarkers and therapeutic targets via multi-omics analysis and artificial intelligence strategies

Fig. 2

Enrichment analysis of hub genes in IVDD. A Following standard quality control on all cells pertaining to mild and severe IVDD, 9,161 cells were included in the analysis. B A UMAP plot illustrates six distinct cell types within the dataset, as identified through unsupervised clustering (NPCs, nucleus pulposus cells; NPPCs, nucleus pulposus progenitor cells; Noto, notochord cells; EC, erythroid cells). Each color represents a specific cell type. C Proportions of different cell types in mild-IVDD and severe-IVDD samples. D UMAP plots depict the distribution of AA metabolic activity in each cell. E, F A violin plot displays the AA metabolic score of various cell types in mild IVDD and severe IVDD. G, H A violin plot displays the AA metabolic score of NPCs in mild IVDD and severe IVDD

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Lipids in Health and Disease

ISSN: 1476-511X