Table 2 GO terms associated with fibrosis and inflammation in transcriptomics analysis

Fibrotic process

microfibril

Mfap5, Ltbp1, Mfap4, Mfap2

30.39

2.23E-06

1.70E-04

collagen-activated signaling pathway

Col1a1, Col4a5, Ddr2, Itga11

Ubash3b, Oscar

27.35

3.64E-08

8.45E-06

collagen-activated tyrosine kinase receptor signaling pathway

Col1a1, Col4a5, Ddr2

Ubash3b

22.80

6.66E-06

3.52E-04

collagen trimer

Col4a5, C1qtnf5, Col6a1, Cthrc1, C1qtnf6, Col1a1, Col6a2, Col14a1

Fcnb

14.55

1.36E-09

7.10E-07

collagen catabolic process

Mrc2, Mmp2, Ctsk, Mmp14

12.43

7.70E-05

2.05E-03

collagen binding

Aspnl1, Aspn, Antxr1, Mrc2, Ctsk, Col6a2, Itga11, Lum, Ddr2, Col6a1

12.00

8.02E-09

3.05E-06

collagen-containing extracellular matrix

Ssc5d, Lum, Col6a2, Gpc1, Eln, Thbs4, Ntn4, Col1a1, LOC102553715, Adamtsl4, Hmcn1, Tgfb3, Col14a1,

LOC103690116, Col6a1, Timp3, Ltbp1, Smoc1, Adamts2, Mfap4, Angptl1, Lama2, Ecm1, Matn4, Fbln2, Col4a5, Bmp7, Postn

Timp1, Serpine1, Fcnb, Rarres2

11.46

8.21E-23

1.14E-19

extracellular matrix binding

Ecm1, Gpc1, Ssc5d, Smoc1, Ntn4, Fbln2, Eln, LOC100911932

11.40

2.58E-07

3.72E-05

Inflammatory process

chemokine activity

Cxcl13, Ccl5, Ccl21

Cxcl1, Ccl7, Cxcl6

11.40

5.28E-06

2.94E-04

regulation of monocyte chemotaxis

Ccl5, Nbl1

Serpine1, Pla2g7

11.40

1.11E-04

2.54E-03

positive regulation of macrophage migration

Mdk, Mmp14, Il34

Rarres2

10.52

1.55E-04

3.26E-03