Drug Target | Methods | IBD | UC | CD | |||
---|---|---|---|---|---|---|---|
OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | ||
ABCG5 (APOB) | WM | 0.78 (0.54- 1.14) | 0.2 | 0.82 (0.53- 1.26) | 0.37 | 0.61 (0.36- 1.03) | 0.07 |
IVW | 0.84 (0.64- 1.12) | 0.23 | 0.92 (0.66- 1.31) | 0.66 | 0.83 (0.52- 1.30) | 0.41 | |
ABCG5 (LDL) | WM | 0.77 (0.54- 1.09) | 0.14 | 0.85 (0.56- 1.30) | 0.46 | 0.62 (0.38- 1.02) | 0.06 |
IVW | 0.83 (0.64- 1.09) | 0.19 | 0.93 (0.68- 1.27) | 0.64 | 0.79 (0.52- 1.22) | 0.29 | |
APOB (LDL) | WM | 1.07 (0.89- 1.28) | 0.47 | 0.98 (0.75- 1.27) | 0.86 | 1.09 (0.87- 1.36) | 0.46 |
IVW | 0.98 (0.86- 1.12) | 0.75 | 0.88 (0.71- 1.08) | 0.22 | 1.07 (0.91- 1.25) | 0.44 | |
APOB (APOB) | WM | 0.99 (0.85- 1.15) | 0.9 | 0.93 (0.77- 1.13) | 0.47 | 0.98 (0.82- 1.17) | 0.8 |
IVW | 0.97 (0.88- 1.08) | 0.62 | 0.87 (0.75- 1.00) | 0.05 | 1.07 (0.94- 1.22) | 0.32 | |
APOC3 (APOB) | WM | 0.59 (0.39- 0.90) | 1.50E-02 | 0.46 (0.26- 0.82) | 8.40E-03 | 0.78 (0.48- 1.27) | 0.32 |
IVW | 0.52 (0.38- 0.69) | 9.90E-06 | 0.41 (0.27- 0.63) | 5.10E-05 | 0.67 (0.46- 0.97) | 3.50E-02 | |
APOC3 (TG) | WM | 0.89 (0.79- 1.01) | 0.06 | 0.90 (0.78- 1.04) | 0.16 | 0.94 (0.82- 1.07) | 0.35 |
IVW | 0.87 (0.80- 0.95) | 2.30E-03 | 0.83 (0.73- 0.94) | 2.80E-03 | 0.90 (0.81- 0.99) | 3.70E-02 | |
HMGCR (APOB) | WM | 0.69 (0.47- 1.00) | 5.00E-02 | 0.74 (0.44- 1.25) | 0.26 | 0.57 (0.36- 0.90) | 1.50E-02 |
IVW | 0.68 (0.52- 0.91) | 8.70E-03 | 0.76 (0.45- 1.29) | 0.31 | 0.64 (0.44- 0.92) | 1.50E-02 | |
HMGCR (LDL) | WM | 0.70 (0.50- 0.97) | 3.10E-02 | 0.73 (0.47- 1.12) | 0.15 | 0.64 (0.42- 0.98) | 3.80E-02 |
IVW | 0.72 (0.56- 0.92) | 8.70E-03 | 0.76 (0.52- 1.11) | 0.15 | 0.68 (0.50- 0.94) | 1.80E-02 | |
LDLR (APOB) | WM | 1.16 (0.95- 1.43) | 0.15 | 0.90 (0.69- 1.17) | 0.43 | 1.53 (1.16- 2.01) | 0.0026 |
IVW | 1.20 (1.04- 1.38) | 1.10E-02 | 0.89 (0.74- 1.08) | 0.24 | 1.43 (1.19- 1.71) | 1.30E-04 | |
LDLR (LDL) | WM | 1.17 (0.95- 1.43) | 0.14 | 0.90 (0.70- 1.16) | 0.43 | 1.48 (1.14- 1.94) | 0.0036 |
IVW | 1.18 (1.03- 1.36) | 1.80E-02 | 0.90 (0.75- 1.07) | 0.24 | 1.40 (1.17- 1.67) | 2.60E-04 | |
LPL (APOB) | WM | 1.95 (1.11- 3.43) | 2.00E-02 | 1.50 (0.72- 3.12) | 0.27 | 2.42 (1.18- 4.95) | 1.60E-02 |
IVW | 2.10 (1.35- 3.28) | 1.10E-03 | 1.64 (0.93- 2.90) | 0.09 | 2.55 (1.44- 4.53) | 1.30E-03 | |
LPL (TG) | WM | 1.17 (1.02- 1.33) | 2.00E-02 | 1.08 (0.92- 1.28) | 0.33 | 1.19 (1.01- 1.41) | 4.00E-02 |
IVW | 1.20 (1.09- 1.33) | 1.70E-04 | 1.12 (0.99- 1.27) | 0.06 | 1.26 (1.11- 1.43) | 2.60E-04 | |
NPC1L1 (APOB) | WM | 1.85 (0.78- 4.39) | 0.17 | 1.64 (0.56- 4.76) | 0.37 | 2.50 (0.80- 7.86) | 0.12 |
IVW | 2.15 (0.93- 4.99) | 0.07 | 2.04 (0.84- 4.94) | 0.12 | 2.07 (0.65- 6.61) | 0.22 | |
NPC1L1 (LDL) | WM | 1.68 (0.84- 3.34) | 0.14 | 1.65 (0.67- 4.06) | 0.28 | 2.84 (1.07- 7.59) | 3.70E-02 |
IVW | 1.94 (1.04- 3.61) | 3.70E-02 | 1.91 (0.92- 3.96) | 0.08 | 1.63 (0.65- 4.11) | 0.3 | |
PCSK9 (APOB) | WM | 1.00 (0.76- 1.31) | 0.98 | 1.13 (0.79- 1.61) | 0.5 | 0.75 (0.52- 1.09) | 0.13 |
IVW | 0.87 (0.70- 1.07) | 0.18 | 1.01 (0.78- 1.29) | 0.96 | 0.72 (0.54- 0.95) | 2.00E-02 | |
PCSK9 (LDL) | WM | 1.00 (0.76- 1.31) | 0.98 | 1.13 (0.80- 1.60) | 0.49 | 0.76 (0.53- 1.08) | 0.12 |
IVW | 0.88 (0.72- 1.07) | 0.2 | 1.02 (0.80- 1.30) | 0.87 | 0.73 (0.56- 0.96) | 2.20E-02 | |
PPARA (TG) | Wald ratio | 2.20 (0.41–11.85) | 0.36 | 3.25 (0.38–27.68) | 0.28 | 2.40 (0.28- 20.91) | 0.43 |