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Fig. 5 | Lipids in Health and Disease

Fig. 5

From: The novel molecular mechanism of pulmonary fibrosis: insight into lipid metabolism from reanalysis of single-cell RNA-seq databases

Fig. 5

Regulation of FA Metabolism Pathways. ACLY utilizes cytoplasmic citrate to produce cytosolic acetyl-CoA, which is then used as a substrate by ACC to produce malonyl-CoA. FASN could convert acetyl-CoA and malonyl-CoA into long-chain saturated fatty acids for palmitate synthesis. SCD plays a critical role in the synthesis of unsaturated FAs, particularly oleic acid. The ELOVLs are involved in fatty acid elongation. In FA catabolism, acyl-CoA synthetases (ACSLs) first degrade long-chain FAs (LCFAs) to fatty acyl-CoA esters. Subsequently, mitochondrial carnitine palmitoyltransferases (CPT1/II), in conjunction with a carnitine-acylcarnitine translocase, induce the oxidation of LCFAs, which are ultimately broken down to acetyl-CoA via the β-oxidation pathway in the mitochondria

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Lipids in Health and Disease

ISSN: 1476-511X