Table 4 DEGs of cholesterol metabolism in PF cells
Cell Type | AT2 | Fibroblast | Macrophage | Endothelium | ||||
|---|---|---|---|---|---|---|---|---|
Significance | Fold Change | P value | Fold Change | P value | Fold Change | P value | Fold Change | P value |
SREBF1 | / | / | − 0.57 (FB) | 4.15 E-03 | − 0.20 (AM) | 1.66 E-03 | − 0.58 | 1.91 E-06 |
SREBF2 | −0.14 | 1.27E-02 | / | / | 0.23 (IM) | 3.51 E-42 | / | / |
0.07 (AM) | 4.19 E-02 | |||||||
NR1H2 | −0.38 | 5.61 E-24 | / | / | −0.13 (IM) | 7.63 E-10 | −0.24 | 5.95 E-04 |
−0.30 (AM) | 8.00 E-37 | |||||||
NR1H3 | / | / | / | / | 0.55 (IM) | 2.55 E-144 | / | / |
−0.20 (AM) | 1.08 E-14 | |||||||
LDLR | −0.43 | 3.18 E-44 | / | / | 0.21 (IM) | 1.14 E-18 | / | / |
0.56 (AM) | 9.63 E-59 | |||||||
FASN | −0.59 | 5.43 E-130 | / | / | / | / | / | / |
SCD | / | / | −1.04 (FB) | 7.92 E-03 | 0.32 (IM) | 3.42 E-61 | / | / |
−0.14 (AM) | 2.80 E-21 | |||||||
PCSK9 | −1.03 | 5.02 E-44 | / | / | / | / | / | / |
ABCA1 | / | / | −1.11 (FB) | 3.04 E-33 | −0.63 (IM) | 0.00 E+ 00 | / | / |
−0.54 (MyoFB) | 5.29 E-03 | −0.66 (AM) | 5.32 E-233 | |||||
ABCG1 | / | / | / | / | −0.04 (IM) | 3.56 E-03 | −0.25 | 6.74 E-03 |
0.11 (AM) | 5.00 E-28 | |||||||
ACAT1 | −0.52 | 7.51 E-55 | / | / | 0.07 (IM) | 1.66 E-02 | −0.17 | 1.44 E-02 |
−0.17 (AM) | 7.01 E-17 | |||||||
ACAT2 | −1.15 | 1.79 E-130 | / | / | / | / | / | / |